Julio Jones is in line for a monster week against the Eagles on Monday night, as they allowed the most points to opposing receivers last year.
Jarvis Landry's ascension to No. 1 receiver in Miami should only be aided Sunday by a matchup with the Washington Redskins, a team that allowed a league-worst 35 touchdown passes in 2014.
A.J. Green has a great match-up against a Raiders defense that struggled against the pass in 2014, setting the stage for him to have a good game out of the gate.
Antonio Brown has an excellent match-up against a beatable Patriots defense in what looks to be a shootout between high scoring offenses.
Randall Cobb will draw the Bears' top corner, Kyle Fuller, but with quarterback Aaron Rodgers averaging over 300 yards and four touchdowns in his last three contests against Chicago, Cobb could post a sound line Sunday.
Julian Edelman is the No. 1 wideout on the defending Super Bowl champions, will have Tom Brady throwing him the pigskin Thursday and faces a Pittsburgh Steeler defense struggling to find an identity following years of supremacy.
Davante Adams enters the season as the favorite to take over the team's second receiving role due to the season-ending injury to Jordy Nelson, and has a juicy Week 1 matchup against a retooled Bears secondary.
Emmanuel Sanders figures to thrive Sunday against a Ravens defense that should force Peyton Manning to get rid of the ball quickly, but may not have the cornerbacks to keep Sanders under wraps out of the slot.
Odell Beckham gets to feast on a Dallas Cowboy secondary that he lit up for four touchdowns in his rookie season and will be without the services of standout corner Orlando Scandrick.
Dez Bryant was limited this preseason with a hamstring injury, but it's not expected to limit him in a Week 1 matchup against the Giants, a team Bryant torched for 16 catches, two scores and nearly 250 yards in a pair of meetings last season.
Jordan Matthews has a nice matchup in Week 1, elevated to WR1 in an up-temp offense and facing a poor Atlanta Falcons pass defense that ranked 30th last year in sacks.
T.Y. Hilton, a top-six receiver in yards, yards per catch and yards per game last season, and the Colts' aerial show go on the road in Week 1 against the Bills, one of the league's top defenses in 2014.
Torrey Smith joins the 49ers as their main deep threat, but Colin Kaepernick has struggled with accuracy on deep throws in the past and the team has a tough Week 1 matchup against a Vikings defense that ranked seventh in passing yards allowed per game in 2014.
DeAndre Hopkins takes over the lead wide receiver for the Texans this season, beginning with their Week 1 meeting with the Chiefs. He'll get some of the 146 targets that went to Andre Johnson last season.
After seeing fewer than two targets per game last season, Ted Ginn Jr. has a chance to fill the void left by Kelvin Benjamin in Week 1 against the Jaguars.
A Week 1 matchup against the New Orleans Saints and their bottom-five defense should help the veteran Fitzgerald put last year's struggles behind him.
Kendall Wright had a good preseason working with Tennessee's first-round pick, quarterback Marcus Mariota, and looks to continue that on-field rapport in Week 1 against the Buccaneers, who ranked 28th in passing yards allowed per game in 2014.
Rueben Randle could see an increased role against a suspect Dallas secondary if Victor Cruz is held out of action in the season opener.
Nelson Agholor gets a nice soft spot for his NFL debut, facing an Atlanta Falcons' defense that struggled to apply pressure on opposing quarterbacks last season (tied for 30th in the league).
Michael Floyd's questionable tag with a finger injury clouds his outlook in what should be a favorable matchup against a vulnerable New Orleans secondary in Week 1.
With no Kelvin Benjamin, Corey Brown should build off his promising rookie year with a plum matchup against the Jaguars.
Brown could see a larger role against a vulnerable New Orleans secondary while teammate Michael Floyd is questionable with a finger injury.
Charles Johnson is a likely beneficiary of high target numbers Monday against a rebuilding 49ers defense that appears ripe for attack by a budding quarterback in Teddy Bridgewater.
Allen Hurns moves up the target list as Marqise Lee (hamstring) and Julius Thomas (hand) are unavailable for the Jaguars' Week 1 match up against a Panthers team that defended the pass well in 2014.
Golden Tate will have less defensive attention but also fewer targets thanks to a healthy Calvin Johnson, as the Lions get set to play a sound San Diego Chargers secondary Sunday.
Allen Robinson becomes the Jaguars' number one target with Julius Thomas (hand) unavailable for the Week 1 matchup against the Panthers, who ranked 11th in passing yards allowed per game in 2014.
Sammy Watkins will have a new quarterback in Tyrod Taylor on Sunday against the Indianapolis Colts, but the Colts defense gave up 27 touchdowns through the air in 2014, which was in the bottom third of the league.
Pierre Garcon figures to get a larger share of the team targets than usual with the Miami defense expected to put pressure on Kirk Cousins, limiting the downfield looks to DeSean Jackson.
Keenan Allen is healthy and motivated to rebound from a disappointing 2014, but Sunday's matchup against a Lions defense that was third in interceptions and ninth in QB rating against last year won't give him an easy path to redemption.
Jeremy Maclin showed good chemistry with Alex Smith in the preseason and will try to take advantage of a weak Texans secondary in his Chiefs debut Sunday.
Wheaton is the starting number two receiver for a Steelers passing attack that faces an average defense in a game between two offenses that both finished in the top-7 in the NFL in points scored in 2014.
Kenny Stills comes to the Miami Dolphins looking to build off a near 1,000-yard season in 2014; he'll face a Washington Redskins defense that gave up 249 passing yards per game in 2014.
Demaryius Thomas may see more short routes than usual Sunday if the Ravens pass rush doesn't give Peyton Manning much time to let a play develop, but the receiver is still a big-play threat any time he gets the ball in his hands.
Brandin Cooks should return to being Drew Brees’ safety blanket Sunday against a leaky Cardinals pass defense.
Mike Wallace has the speed to exploit a rebuilt 49ers secondary Monday night, though questions remain about his initial chemistry with quarterback Teddy Bridgewater.
Mike Evans quickly established himself as a top red zone target, seeing an average of one look there per game, and should provide a big target against the Titans for Jameis Winston in his first game.
Devin Funchess is eager to show why many believe he can be the guy to fill Kelvin Benjamin’s shoes, but may not see the targets in Week 1 to live up to his potential.
Kamar Aiken has a solid match-up against a beatable Broncos pass defense, but his lack of experience in his new starting role makes him a risky play in Week 1.
Alshon Jeffery is the clear No. 1 receiver for the Bears with Brandon Marshall now a New York Jet, but Jeffery is questionable to play in Week 1 due to a calf injury.
Marvin Jones has a favorable match-up against a poor Raiders pass defense, but he will be competing with several other talented Bengals options in a run-oriented scheme which makes him a risky play on any given week.
Amari Cooper may not get a chance to live up to his draft pedigree Sunday due to questionable efficiency from Derek Carr and a rebuilding offensive line that could struggle in protection against a healthy Bengals front seven.
Phillip Dorsett lines up as the third wide receiver for the Colts in their Week 1 game against the Bills, who will have their challenges to stop all of Indianapolis' weapons.
DeSean Jackson could struggle to get open downfield, with a solid front seven of the Miami Dolphins expected to apply plenty of pressure to quarterback Kirk Cousins.
Harry Douglas opens the season as a starting wideout for the exciting Marcus Mariota in the Titans' Week 1 game against the Buccaneers, the NFL's 28th-ranked team in passing yards allowed per game in 2014.
Doug Baldwin figures to have a tough time impacting the passing game as Seattle looks to unveil shiny new toy Jimmy Graham against the Rams in Week 1.
Brandon Marshall has the unenviable task of going up against All-Pro cornerback Joe Haden on Sunday, with career journeyman Ryan Fitzpatrick as his quarterback, when the Jets host the Browns.
Andrew Hawkins could prove to be a good volume/possession receiver in Week 1 against an average Jets passing defense, capable of making short receptions for reasonable yardage but without much upside to get into the end zone.
Michael Crabtree isn't likely to have a big yardage day in his first game as part of the inefficient Raiders passing game, but pressure from the Bengals front seven could make him a frequent target on short routes as Derek Carr's safety valve.
Terrance Williams was quiet in two games against the Giants last year (two catches, 36 yards) but possesses big-play ability for those looking for flex options in deeper leagues.
Eric Decker should have a favorable matchup since Brandon Marshall will draw coverage from Joe Haden against the Cleveland Browns on Sunday, but the presence of quarterback Ryan Fitzpatrick under center remains the real concern for the New York Jets.