Saquon Barkley will continue to be the bell cow for the Giants in their Week 17 matchup versus the Cowboys; though Dallas is allowing just 91.3 rushing yards per game, which is fifth in the league, the Cowboys may decide to rest some players since their playoff position is set, which could mean even more space for Barkley to roam.
Chris Carson has averaged over 100 combined yards over the Seahawks' last four games, and he'll have a fantastic Week 17 matchup against an Arizona defense that gives up the second-most fantasy points to opposing RBs.
Christian McCaffrey will face New Orleans' top-ranked run defense in Week 17 if he's not rested, but Carolina's workhorse back should make up for any deficiencies on the ground with aerial production, as he's already set the record for catches by a running back this season.
Derrick Henry continued his fantasy roll last week, finding the end zone for a fourth straight game, and he should be Tennessee's featured weapon in Week 17 against the Colts.
Doug Martin ran for over 100 yards for the first time all season Monday, and he should be in line for another productive performance in Week 17 when the Raiders take on a Chiefs defense that ranks 30th in YPC allowed and 31st in rushing TDs allowed.
Sony Michel broke off strong run after strong run against the Bills, breaking the 100-yard threshold, and should find plenty of room to run against the Jets, who allowed 6.3 yards per carry to the Packers and their moribund rushing attack last week.
Jamaal Williams has next to no competition for touches for the Packers in Week 17 against a Lions defense that allows 4.4 yards per carry and 114.3 yards per game, so long as a potential concussion sustained last week proves to be nothing more.
James Conner missed his third straight game last week, and if he is ready to go in Week 17, he'll have a great matchup when the Steelers take on the Bengals, who give up the most fantasy points per game to running backs.
Todd Gurley missed the Rams' last game with a knee injury, but if he's in the 49ers Week 17 lineup, he'll be an elite fantasy option against a 49ers defense that's in the middle of the pack in terms of fantasy production allowed to opposing RBs.
Damien Williams has scored five TDs in the last three games, and with Spencer Ware still dealing with a hamstring injury, Williams figures to lead the Chiefs' backfield again in Week 17 against a Raiders defense that's given up the third-most rushing yards per game.
James White found the end zone to help prop up his day from a fantasy perspective (41 rushing yards and two receptions for 13 yards on four targets), but should find himself back amongst the leaders against the Jets, who allowed six receptions for 61 yards to Jamaal Williams last week.
LeSean McCoy returned to the fold after being benched for the first play and mustered just nine yards on six carries against the Patriots, but has a chance to close out his season on a high note against the Dolphins and their third-worst run defense in Week 17.
Melvin Gordon returned from a three-game absence Saturday and managed only 54 scrimmage yards while scoring a TD, but he should post bigger numbers in Week 17 when the Chargers take on a Broncos defense that ranks in the middle of the pack in production allowed to opposition RBs.
Rashaad Penny (knee) is expected to return when the Seahawks face the Cardinals in Week 17, and he should be able to put together significant fantasy value on limited touches against an Arizona defense that allows the second-most fantasy points to opposing RBs.
Jordan Howard has averaged 16.8 carries over the Bears last four games, scoring twice, entering a Week 17 matchup against a Vikings defense that has allowed top opposing runnings backs to go for at least 72 yards and a touchdown in three of their last five games.
Tevin Coleman's Week 17 status is in jeopardy after he departed Atlanta's Week 16 tilt with a groin injury, but he'll likely land around the 10-11 touch range for the fourth consecutive game should Coleman suit up against the Buccaneers.
David Johnson has failed to run for four yards per carry in any of his last four games, but he'll be a volume-driven fantasy option when the Cardinals face a middling Seattle run defense in Week 17.
Keith Ford led the Bills in rushing last week (with seven carries and 33 yards), but will have more opportunities against the Dolphins and their third-worst run defense in Week 17.
With Matt Breida (ankle) set to miss the 49ers' Week 17 contest against the Rams, Jeff Wilson will be a strong, volume-based fantasy option against a Rams defense that allows the 12th-most fantasy points to opposing RBs.
Kenyan Drake led the Dolphins in rushing attempts and receptions with no Frank Gore in the mix, but expectations should be tempered by his six carries and four receptions heading into a Week 17 matchup with the Bills, who allowed 273 rushing yards against the Patriots.
Ezekiel Elliott has gained over 100 yards from scrimmage in eight-straight games but has been held out of the end zone in three-straight contests; it remains to be seen how much the Dallas starters will play in Week 17 versus the Giants, as the Cowboys are locked into the No. 4 seed in the NFC playoffs.
Zach Zenner continues to be the more effective of the Lions' committee backfield mates, but with continued split carries with LeGarrette Blount, he has too few chances to successfully exploit a Packers 20th ranked run defense that allows 119.6 ypg and 4.4 ypc.
C.J. Anderson was dominant in last week's game, and if Todd Gurley is forced to sit out in Week 17, Anderson will be a solid fantasy option when the Rams face a 49ers defense that's in the middle of the pack in terms of fantasy production allowed to opposing RBs.
Gus Edwards had his fourth game this season with over 100 total yards last week, and he'll have a good chance to get his fifth in Week 17 when the Ravens take on the Browns, who give up the ninth-most fantasy points per game to running backs.
Cordarelle Patterson ran for 66 yards on four carries as the Patriots relied heavily on the run against the Bills and could look to their converted wide receiver on the ground again versus the Jets in Week 17, who have allowed the seventh-most rushing yards per game this season.
Rod Smith is likely to see increased work in Week 17 for the Cowboys versus the Giants, as Dallas has locked up its playoff spot and could rest its starters; the Giants have nothing to play for and are allowing 123.1 rushing yards per game, which is 23rd in the NFL.
Nick Chubb had his second straight week with at least 100 yards rushing, but he'll struggle to make it three in a row in Week 17 when the Browns take on a Ravens defense that gives up the second-fewest fantasy points per game to running backs.
Jaylen Samuels continues to produce with James Conner out last week when he totaled 64 yards and a touchdown, plus in Week 17, he'll have another good matchup if Conner is out when the Steelers face the Bengals, who give up the most fantasy points per game to running backs.
Chris Ivory was once again inactive against the Patriots and will look to close out the season for the Bills in Week 17 against the Dolphins, who are allowing the third-most rushing yards per game.
Leonard Fournette salvaged a third straight game with under 50 yards by scoring his fifth TD and looks to finish a tough season on a high note in Week 17 against Houston's fourth-ranked rush defense.
Brian Hill rushed for 115 yards on just eight carries after Tevin Coleman exited last week's tilt with a groin injury, so the 23-year-old Wyoming product will have plenty of Week 17 streaming appeal against the Buccaneers should Coleman need to sit out for Atlanta.
Joe Mixon had his lowest yardage total in five weeks last week when he only had 78 total yards, but in Week 17 the Bengals are taking on the Steelers, who allow the sixth-fewest fantasy points per game to running backs.
Marlon Mack had just 34 rushing yards last week but scored his fourth touchdown in the last three games, putting the Colts in playoff position entering Week 17 against Tennessee.
Adrian Peterson notched his third 100-yard rushing output of the season last game for the Redskins but will face an Eagles defense in Week 17 allowing just 102 rushing yards per game in 2018, which is seventh in the NFL.
Lamar Miller (ankle) was inactive last week, and the Texans' running game suffered, but coach Bill O'Brien is hopeful he'll go Week 17 against the Jaguars' 18th-ranked run defense.
Peyton Barber has topped 50 rushing yards just once in the past five games, but he does have three touchdowns in that stretch and should once again head Tampa Bay's backfield against the Falcons in Week 17.
Darren Sproles notched over 100 yards from scrimmage and a touchdown last game while also leading all Eagles running backs in touches; Sproles is trending upwards heading into a Week 17 clash with a Redskins defense allowing 115.4 rushing yards per game, which is 17th in the NFL.
Kalen Ballage saw just four carries even without Frank Gore in the Dolphins backfield and will look to find room to run against a Bills defense that allowed 273 to the Patriots last week.
Dwayne Washington could find himself handling a heavy workload for the Saints in Week 17, as both Alvin Kamara and Mark Ingram are likely to be rested for this matchup against the Panthers.
Nyheim Hines has carved out a niche as Indianapolis' receiving back, but that will be challenging role in Week 17 against a Titans defense that ranks first in receiving yards allowed to RBs.
Josh Adams has been held under 40 yards rushing in three-straight games for the Eagles while losing touches to a healthy Darren Sproles; Philadelphia will face a Redskins defense in Week 17 allowing 115.4 rushing yards per game, which is 17th in the NFL.
Alfred Blue has not impressed as a full-time fill-in for Lamar Miller (ankle), but could be asked to do so once again if playoff-bound Houston holds Miller out Week 17 against the Jaguars' 18th-ranked rushing defense.
Charcandrick West caught a TD pass in his first significant action of the season Sunday, and injuries to Spencer Ware and Darrel Williams could hand West a larger role in the Chiefs' backfield in Week 17 against a Raiders defense that's given up the third-most rushing yards per game in the league.
T.J. Yeldon was declared a healthy scratch last week, leaving him with little expectation heading into Week 17 when Jacksonville travels to Houston.
D'Onta Foreman made his season debut last week, catching a TD pass while looking rusty as a runner, and could play again Week 17 if Houston holds Lamar Miller (ankle) out against Jacksonville.
Kenneth Dixon has locked down the backup running back spot for the Ravens behind Gus Edwards, however, Dixon has limited value with Edwards and Lamar Jackson getting a lot of touches before him but in Week 17, he'll have a good matchup against the Browns, who give up the ninth-most fantasy points per game to running backs.
Devontae Booker picked up 42 scrimmage yards Monday, and if Phillip Lindsay's wrist injury keeps him sidelined for Week 17, Booker could see a much bigger role in the Broncos' backfield against a Chargers defense that's allowed the third-most receiving yards in the league to opposition RBs.
Royce Freeman carried the ball seven times for 21 yards Monday, and if Phillip Lindsay's wrist injury keeps him sidelined for Week 17, Freeman could see a much bigger role in the Broncos' backfield against a Chargers defense that ranks ninth in rushing yards allowed per game.
Dave Williams, coming off an encouraging Week 15, did not get a touch last week, leaving his role uncertain heading into the season finale against Houston in Week 17.
Elijah McGuire averaged just 2.5 yards per carry against the Packers last week and faces a Patriots defense that's in the top-half against the run in Week 17.