Andy Dalton could get a second chance to lead the Carolina offense if Bryce Young remains sidelined, and he'd face a Vikings defense in Week 4 that has allowed the third-most fantasy points per game to quarterbacks.
Justin Herbert is coming off a massive 405-yard, three-TD performance last week, and he could post big numbers again in Week 4 as the Chargers host a Raiders defense that ranks 31st in QB rating against so far in 2023.
Russell Wilson has topped 300 passing yards in back-to-back games as the Broncos defense struggles to stop the opposition, and he figures to be productive again in Week 4 against a Bears defense that ranks 30th this season in passing yards per game allowed.
Desmond Ridder has averaged only 6.3 yards per attempt as the leader of the Falcons' offense, but he'll head into a Week 4 matchup against a Jaguars defense that has allowed opposing quarterbacks to score 21.6 fantasy points per game.
Daniel Jones has thrown for over 140 yards in just one of three games for the Giants but will face a soft Seattle passing defense in Week 4 allowing 328 passing yards per tilt, which is second-worst in the NFL.
Kirk Cousins has thrown for at least 344 yards in each of Minnesota's first three contests, and in Week 4 he gets a Panthers defense that has surrendered 27.0 points per game in 2023, the eighth-highest total in the league.
Patrick Mahomes has thrown multiple touchdown passes in every game to begin 2023, but the Kansas City superstar gets a challenging matchup in Week 4 against a Jets defense that has yet to allow a QB to top 255 passing yards this season.
Geno Smith is averaging over 300 yards passing over the last two games for Seattle but will face a Giants defense in Week 4 allowing 223 passing yards per tilt, which is 18th in the NFL.
Brock Purdy has thrown four touchdowns in three games for the 49ers and will face a Cardinals defense in Week 4 that's allowed four passing touchdowns through three contests in 2023.
Jameis Winston is likely to make his first start since Week 3 of the 2022 season as the Saints head into a Week 4 matchup against a Tampa Bay defense that has allowed a league-average 18.7 fantasy points per game.
Jalen Hurts has tossed as many interceptions as touchdowns thus far this season for the Eagles, though does have three rushing scores in his last two games and will face a Washington defense in Week 4 that's allowed three rushing scores in three games in 2023.
Justin Fields has yet to top 59 rushing yards or a 64.9 completion percentage in a game this season for the Bears, but in Week 4 he gets a Denver defense that has allowed league highs in rushing yards per game (177.7) and completion percentage (77.4).
Jordan Love is coming off a 17-point, fourth-quarter comeback for the Packers, and in Week 4 he'll get a Detroit defense that has allowed 21.0 points per game so far this season, ranking in the middle of the pack.
Matthew Stafford is averaging over 300 yards passing per game this season for the Rams but has tossed four picks over his last two contests, giving him some volatility heading into Week4 and a clash with a subpar Colts passing defense that's allowing 250.7 passing yards per tilt, which is 23rd in the NFL.
Lamar Jackson ran for 101 yards and two touchdowns last week with the Ravens' backfield once again riddled by injuries, but he figures to find less success in Week 4 against a Browns defense that ranks first in passing yards per game allowed and has given up minus-8 rushing yards to QBs so far in 2023.
Josh Allen has accounted for multiple touchdowns in two of three outings this season for the Bills, and in Week 4, he'll get a Dolphins defense that has given up 16.9 fantasy points per game to quarterbacks so far in 2023, which ranks in the middle of the pack.
Trevor Lawrence has a pedestrian 3:2 TD:INT through three games after posting a 25:8 TD:INT for the Jaguars last season, and in Week 4, he'll travel to London to face a Falcons defense that's allowing just 170 passing yards per game.
Jared Goff has thrown for more than 240 yards and a touchdown in each game this season for the Lions, and in Week 4 he'll face a Packers defense that has allowed 219 passing yards per game this season, which ranks in the middle of the pack.
Kenny Pickett threw multiple touchdown passes last week for the first time in his NFL career, but he's unlikely to repeat that feat in Week 4 as the Steelers face a Texans defense that's given up seven TDs on the ground but only two through the air so far in 2023.
Sam Howell tossed four picks last week for the Commanders but will face an Eagles defense in Week 4 that had allowed seven throwing scores through its first two games of the season.
Joe Burrow has failed to throw a touchdown in two of three games as he plays through a calf injury, so he may not take full advantage of a juicy matchup in Week 4 as the Bengals take on a Titans defense that ranks 28th in passing yards per game allowed so far in 2023.
Dak Prescott managed just one touchdown in five trips to the red zone last game for Dallas and will face a Patriots defense in Week 4 that's allowed just two passing touchdowns through three games in 2023.
Zach Wilson has yet to throw for more than 170 yards in a game this season for the Jets, and in Week 4, he gets a Chiefs defense that has allowed just 11.6 fantasy points per game to quarterbacks so far in 2023, the sixth-lowest total in the league.
Joshua Dobbs has combined for three touchdowns in his last two games for Arizona but will face a San Francisco squad in Week 4 allowing just 14 points per contest, which is fifth in the NFL.
Baker Mayfield has thrown for under 200 yards and only one touchdown in two of three games as the Buccaneers head into a Week 4 matchup against a Saints defense that has allowed only 14.7 fantasy points per game to opposing quarterbacks.
Ryan Tannehill has only 548 passing yards and a 1:3 TD:INT through three weeks as Tennessee's offensive line has struggled to protect the veteran quarterback, and things won't get any easier in Week 4 against a Bengals defense that's allowing just 200.7 passing yards per game.
Mac Jones has thrown for fewer than two touchdowns per game in his young career for the Patriots, and in Week 4, he gets a Cowboys defense that has allowed only two scores through the air this season.
Brian Hoyer could get the start for the Raiders in Week 4 if Jimmy Garoppolo doesn't clear the league's concussion protocol in time, giving him some dart-throw appeal against a Chargers defense that ranks dead last in passing yards per game allowed so far in 2023.
Tua Tagovailoa has thrown for at least three scores twice in three outings for the Dolphins in 2023, but in Week 4, he'll get a Bills defense that has given up just 7.8 fantasy points per game to quarterbacks so far this season, the second-lowest total in the league.