Justin Herbert is coming off a massive 405-yard, three-TD performance last week, and he could post big numbers again in Week 4 as the Chargers host a Raiders defense that ranks 31st in QB rating against so far in 2023.

Desmond Ridder has averaged only 6.3 yards per attempt as the leader of the Falcons' offense, but he'll head into a Week 4 matchup against a Jaguars defense that has allowed opposing quarterbacks to score 21.6 fantasy points per game.

Kirk Cousins has thrown for at least 344 yards in each of Minnesota's first three contests, and in Week 4 he gets a Panthers defense that has surrendered 27.0 points per game in 2023, the eighth-highest total in the league.

Geno Smith is averaging over 300 yards passing over the last two games for Seattle but will face a Giants defense in Week 4 allowing 223 passing yards per tilt, which is 18th in the NFL.

Jameis Winston is likely to make his first start since Week 3 of the 2022 season as the Saints head into a Week 4 matchup against a Tampa Bay defense that has allowed a league-average 18.7 fantasy points per game.

Justin Fields has yet to top 59 rushing yards or a 64.9 completion percentage in a game this season for the Bears, but in Week 4 he gets a Denver defense that has allowed league highs in rushing yards per game (177.7) and completion percentage (77.4).

Matthew Stafford is averaging over 300 yards passing per game this season for the Rams but has tossed four picks over his last two contests, giving him some volatility heading into Week4 and a clash with a subpar Colts passing defense that's allowing 250.7 passing yards per tilt, which is 23rd in the NFL.

Josh Allen has accounted for multiple touchdowns in two of three outings this season for the Bills, and in Week 4, he'll get a Dolphins defense that has given up 16.9 fantasy points per game to quarterbacks so far in 2023, which ranks in the middle of the pack.

Jared Goff has thrown for more than 240 yards and a touchdown in each game this season for the Lions, and in Week 4 he'll face a Packers defense that has allowed 219 passing yards per game this season, which ranks in the middle of the pack.

Sam Howell tossed four picks last week for the Commanders but will face an Eagles defense in Week 4 that had allowed seven throwing scores through its first two games of the season.

Dak Prescott managed just one touchdown in five trips to the red zone last game for Dallas and will face a Patriots defense in Week 4 that's allowed just two passing touchdowns through three games in 2023.

Joshua Dobbs has combined for three touchdowns in his last two games for Arizona but will face a San Francisco squad in Week 4 allowing just 14 points per contest, which is fifth in the NFL.

Ryan Tannehill has only 548 passing yards and a 1:3 TD:INT through three weeks as Tennessee's offensive line has struggled to protect the veteran quarterback, and things won't get any easier in Week 4 against a Bengals defense that's allowing just 200.7 passing yards per game.

Brian Hoyer could get the start for the Raiders in Week 4 if Jimmy Garoppolo doesn't clear the league's concussion protocol in time, giving him some dart-throw appeal against a Chargers defense that ranks dead last in passing yards per game allowed so far in 2023.