Ben Roethlisberger threw for over 300 yards last week for the eighth time this season, and in Week 17 he'll have chance to make it nine when the Steelers face the Bengals, who give up the most fantasy points per game to quarterbacks.
Patrick Mahomes threw multiple TD passes for the 10th straight game Sunday, and with the Chiefs still fighting for playoff seeding, he seems poised for another huge performance in Week 17 against a Raiders defense that's given up a league-worst 34 passing TDs on the season.
Aaron Rodgers is coming off of his third 400 yard game of the year for the Packers, and as long as they don't choose to sit him out early in Week 17, he'll have ample chances to carve up a Lions secondary that has allowed 29 touchdown passes to date, the league's fourth-highest total.
Nick Foles continues his late season magic for the Eagles, passing for a franchise-best 471 yards along with four touchdowns last game; the Eagles are still in the playoff hunt in Week 17 versus a Redskins squad looking to play spoiler and allowing 238 passing yards per game, which is 14th in the NFL.
Andrew Luck brought the Colts from behind last week, leading three second-half touchdown drives, and giving Indianapolis control of their playoff destiny in Week 17 against Tennessee.
Lamar Miller's injury left Houston without much of a running attack last week, forcing Deshaun Watson to throw 40 times, something he'd like to avoid Week 17 against Jacksonville's fifth-ranked defense in QB rate.
Matt Ryan comes into Atlanta's Week 17 clash with the Buccaneers needing 398 passing yards and five touchdowns to equal his career high totals of 4,944 and 38, both set in 2016.
Tom Brady struggled against the Bills last week, throwing for just 126 yards, one touchdown and two interceptions, but will look to find his stride heading into the playoffs against the hapless Jets, who allowed 442 yards to Aaron Rodgers last week.
Jameis Winston topped 300 yards for the fourth time in 10 appearances last week, and Tampa Bay's quarterback will be hoping for another such performance in Week 17 against a Falcons team that allows 254.1 passing yards per game.
Eli Manning could be playing in his last game as a member of the New York Giants, and will face a Cowboys defense in Week 17 allowing 230.5 passing yards per game, which is ninth in the league, but the Cowboys may decide to rest some players since their playoff position is set.
Philip Rivers threw less than 200 yards and failed to throw a TD for the first time all season in Week 16, but with the Chargers fighting for playoff seeding, he should rebound in Week 17 against a Broncos defense that ranks 12th in QB rating against.
Russell Wilson was held without a TD pass when facing the Cardinals in Week 4, and the Seahawks may not need to rely heavily upon the pass to get a win in Week 17 against the fifth-ranked defense against opposing QBs.
Josh Johnson has at least one passing touchdown in each of the last three games for the Redskins, and will face a Philadelphia defense in Week 17 that's allowed 17 throwing scores in 2018, which is 12th in the NFL.
Matthew Stafford has been held to 116 yards or less in two of the Lions last three games, throwing just three touchdown passes in his last six outings, making him an unappealing option in Week 17 against a vulnerable Packers secondary that has allowed eight touchdown passes in their last three.
Derek Carr failed to throw a TD on Monday but hasn't thrown an INT in his last 325 pass attempts, and he should be more productive in Week 17 when the Raiders take on a Chiefs defense that's allowed the most passing yards in the league.
Kirk Cousins has five touchdown passes in the Vikings last two games, coinciding with a change in offensive coordinator, entering a Week 17 matchup against a Bears defense that has allowed only one touchdown pass over their last five games since Cousins went for 266 yards and two scores against them in Week 11.
Last week, Sam Darnold was the youngest 300-plus yard, three touchdown quarterback since Matthew Stafford and will look to close his rookie season out on a high note heading into Week 17 against the Patriots and their bottom-10 secondary.
Jared Goff is averaging 0.5 TDs over the Rams' last four games, which will make him difficult to trust in Week 17 despite facing a 49ers defense that allows the 12th-most fantasy points to opposing QBs.
Josh Allen completed less than 50 percent of his passes against the Patriots and will look to close the season out on a high note in the Bills Week 17 finale against the Dolphins, who are allowing the third-most yards per game this season.
Teddy Bridgewater will start under center for the Saints in Week 17 against Carolina, as the NFC's top seed will rest regular starter Drew Brees in preparation for the playoffs.
Lamar Jackson threw for over 200 yards for the first time this season, however, he still struggled with a completion percentage of only 54 percent and only rushed for 39 yards last week but in Week 17, the Ravens face off against a Browns team who give up the sixth-most passing yards per game and the ninth-most rushing yards per game.
Dak Prescott scored twice last game and has six rushing touchdowns on the season; however, it remains to be seen how much the Dallas starters will play in Week 17 versus the Giants, as the Cowboys are locked into the No. 4 seed in the NFC playoffs.
Blake Bortles filled in for an injured Cody Kessler (shoulder) last week after riding the Jacksonville bench the last three games and is line to start the season finale Week 17 at Houston.
Marcus Mariota left Tennessee's game last week with an elbow injury, and he'll open the week as questionable for Week 17 against the Colts, a game with playoff implications.
Taylor Heinicke is in danger of missing Carolina's Week 17 match with the Saints due to an elbow injury, in which case third-stringer Kyle Allen would take over as the starting quarterback.
Nick Mullens is averaging fewer than 1.5 TDs over his last six games, and he's unlikely to get back on track in Week 17 when the 49ers play a Rams defense that's gotten fully healthy over the last few weeks.
Case Keenum failed to throw for at least 210 yards Monday for the fourth time in the last five games, and his ceiling will remain limited in Week 17 when the Broncos face a Chargers defense that ranks seventh in passing yards allowed.
Blaine Gabbert rescued the Titans after Marcus Mariota (elbow) left last week's game, directing a pair of fourth-quarter scoring drives, but doesn't have Mariota's upside if needed in Week 17 against Indianapolis.
Baker Mayfield had his second-best fantasy performance of the year last week, throwing for over 280 yards and tossing three touchdown passes, but in Week 17 fantasy owners might want to find another option when the Browns face the Ravens, who give up the fourth-fewest fantasy points per game to quarterbacks.
Kyle Allen could end up starting under center for Carolina in Week 17 if Taylor Heinicke's elbow keeps him out, but the practice squad call-up will be tough to trust despite a favorable matchup against New Orleans' 28th-ranked secondary.
Matt Cassel could see extended action for a struggling Matthew Stafford in Week 17 against a Packers defense that has allowed multiple touchdown passes in three straight and five of their last six if the Lions choose to rest Stafford, who's dealing with a back ailment.
Jeff Driskel has thrown for 200 plus yards only once this season and clearly the Bengals' offense is more run focused with Andy Dalton and A.J. Green out for the rest of the season, which makes Driskel a very risky option in Week 17 when he faces the Steelers.
Cody Kessler was forced to leave Jacksonville's game last week with a right shoulder injury and may be replaced by Blake Bortles in Week 17 against Houston.
Mitchell Trubisky may carry some appeal as a starter for the Bears who knows he'll see meaningful snaps in Week 17, but he's thrown for only one touchdown in three of his last four games and faces a Vikings defense that has held three straight opposing QBs without a touchdown pass and five of the last six to under 200 yards.
Josh Rosen has averaged fewer than 0.5 TD passes over the Cardinals' last five games, and he'll be a weak fantasy option against a Seattle defense that gives up the 12th fewest fantasy points to QBs.
Ryan Tannehill continued to struggle throwing the ball and will face a Bills defense that completely shut down Tom Brady last week in what is likely to be a frigid Week 17 battle in Buffalo.
Cooper Rush, a second-year pro out of Central Michigan, could see the field for the Cowboys in Week 17 versus the Giants, as Dallas may rest its starters with its playoff positioning set; the Giants are giving up 245 passing yards per game, which is 18th in the NFL.
Drew Brees will sit out the Saints' Week 17 matchup against the Panthers with New Orleans having already clinched the No. 1 seed in the NFC, thus offering Teddy Bridgewater a chance to start.
Taysom Hill could see some extra action under center for the Saints in Week 17, but Teddy Bridgewater will get the start at quarterback with Drew Brees resting against the Panthers.