Jeremy Hill is the unquestioned lead back in Cincinnati, coming off a rookie season in which he exploded once entering the starting line-up, and faces a Raiders defense that was terrible against the run in 2014.
DeMarco Murray gets a nice matchup in his Philadelphia debut against an Atlanta defense that was among the league's worst last season.
Doug Martin has had trouble staying on the field and being effective over the past two seasons, but gets a plus matchup against the second-worst run defense from last season in the Titans.
Eddie Lacy could feast on a rebuilding Bears defense which will be without their starting defensive tackle, Jeremiah Ratliff, who is suspended for three games.
Frank Gore makes his Colts debut in Week 1's road game against the Bills, who ranked 11th in rushing yards allowed per game in 2014. He'll benefit greatly as the Bills need to focus on quarterback Andrew Luck.
Currently healthy, Jonathan Stewart gets a good matchup in Week 1 against a below-average Jacksonville run defense that allowed more than four yards per carry.
Carlos Hyde should be able to make an impact in his first start as the lead back for San Francisco against a Vikings defense that allowed the 25th-most rushing yards last year.
Adrian Peterson looks poised to strike Monday night against a 49ers defense that is being completely rebuilt after losing middle linebacker Patrick Willis and defensive end Justin Smith to retirement.
Charles Sims is entrenched as the passing-down back and should see extra touches against the Titans’ poor run defense and as a safety valve for Jameis Winston in his first start.
Darren McFadden figures to have a decent matchup against the Giants on Sunday in a game expected to be a high-scoring affair, given his position on the depth chart behind an unproven Joseph Randle.
Alfred Blue steps into the shoes of Arian Foster, who will miss several weeks with a groin injury, and gets a beneficial match-up in Week 1 against the Chiefs, who were susceptible to the run in 2014.
Bishop Sankey looks to put an underwhelming rookie season behind him in the Titans' Week 1 game against the Buccaneers, who ranked 19th in rushing yards allowed per game in 2014, but he still needs to prove himself as an every-week starter.
Lamar Miller is poised for a breakout season; he faces a Washington Redskins defense in Week 1 that was fairly stingy against the run in 2014, but seems to be trending in the wrong direction in 2015 after losing defensive end Junior Galette for the season.
Ivory is penciled in as the starter for the New York Jets, and Sunday's opponent, the Cleveland Browns, allowed a league-worst 141.6 rushing yards in 2014.
Latavius Murray has the speed and skills to produce good numbers, but could have little space in which to work Sunday behind a rebuilding offensive line that will have its hands full with a healthy and rejuvenated Bengals front seven.
Andre Ellington faces a vulnerable New Orleans Saints defense in a Week 1 matchup at home that should get his season off on the right foot.
C.J. Anderson faces a tough home matchup in Week 1 against a Ravens defense that lost nose tackle Haloti Ngata to the Lions in the offseason but still ranked fourth in rushing yards allowed per game in 2014.
Isaiah Crowell is poised to get the lion share of the carries in Week 1, but against a good Jets run defense his production could still be attenuated.
Taking over as the starter in his second season, Devonta Freeman has good upside in PPR leagues against the second-worst passing defense of the Eagles on Monday night.
Matt Forte has a challenging matchup on Sunday against a Packers' defense that welcomes back nose tackle B.J. Raji from a biceps injury that cost him all of last season.
Marshawn Lynch could have a tougher time than usual running behind a shaky offensive line in Week 1 against the Rams' stout front seven unit.
Ameer Abdullah could find room to run against a Chargers defense that has a sound secondary but few proven commodities among its front seven.
Jamaal Charles could struggle to find running lanes Sunday behind a reshuffled offensive line and facing a J.J. Watt-led Texans defense that added veteran nose tackle Vince Wilfork in the offseason.
Danny Woodhead should see significant third-down snaps while rookie Melvin Gordon works to improve his pass protection, but Sunday's tough matchup against DeAndre Levy and the stingy Lions defense may not provide Woodhead with many targets.
Mark Ingram should find holes behind the Saints’ new-look offensive line but will have to go up against the stingy Cardinals run defense.
Giovani Bernard has the ability of an every down back, but he is stuck behind Jeremy Hill in the rotation which makes him a risky play even against a Raiders defense that struggled against the run in 2014.
LeSean McCoy is nursing a hamstring injury, though coach Rex Ryan figures to give him a hefty load should he suit up Sunday against the Indianapolis Colts; the Bills could be forced to abandon the running game if they fall behind early to Andrew Luck and that high-powered offense, though.
In his NFL debut, Tevin Coleman may not see a ton of touches, but could still have a solid day against a stout Eagles run defense that allowed just 3.7 yards per carry last season.
Ryan Mathews has more value as a handcuff for DeMarco Murray owners than as a weekly option, though he does have some upside in PPR formats, and a possible high-scoring affair in Week 1 is an attractive one if Matthews gets touches.
C.J. Spiller could have a good day Sunday if he's able to play, particularly in PPR formats, in Week 1 against the Cardinals.
T.J. Yeldon will start at running back for the Jaguars in Week 1 against Carolina, but he didn't get much game action in the preseason, and will share the backfield duties with Denard Robinson and Toby Gerhart.
Alfred Morris, with just a single 100-yard effort last year, faces a tough test in a Week 1 matchup against the Miami Dolphins who feature what's expected to be one of the tougher front lines in the league.
Melvin Gordon should get plenty of touches, but he faces an extremely difficult matchup Sunday in his NFL debut against a Lions defense that allowed a league-low 69.3 rushing yards per game in 2014.
Brandon Bolden figures to see some touches against the Pittsburgh Steelers on Thursday, but James White and Dion Lewis could also see carries in what is a backfield situation for fantasy owners to avoid in Week 1.
Benny Cunningham could get the start if Tre Mason can't answer the bell but a Week 1 matchup against the Seahawks figures to prove tough.
James White figures to see some touches against the Pittsburgh Steelers on Thursday, but Brandon Bolden and Dion Lewis could also see carries in what is a nightmare situation for fantasy owners in Week 1.
Duke Johnson may not be available to make his debut in Week 1 due to a concussion, but even if he does he will be the lesser end of a platoon situation against a strong rushing defense.
Matt Jones could see some snaps on passing downs, but isn't expected to make much of an impact in his debut against the stout front seven of the Dolphins.
Jerick McKinnon returns to a backup role by Adrian Peterson as the Vikings travel to face a rebuilding 49ers defense.