Matt Ryan finds himself with a plum season-opening matchup on Monday night against the Eagles’ second-worst pass defense from last season.
Aaron Rodgers has a juicy matchup against a rebuilding Bears defense against which he has thrown for more than 300 yards in three straight meetings.
Tom Brady will take the field Thursday against the Pittsburgh Steelers after his suspension was overturned by a Federal Court Judge; the Steelers defense allowed 30 touchdowns through the air in 2014, which was tied for 28th in the NFL.
Ben Roethlisberger, fresh off his best statistical season as a pro, will start the season in what shapes up to be a high-scoring shootout against Tom Brady and the Patriots' beatable pass defense.
Carson Palmer's talented wideout trio and juicy Week 1 matchup against a shaky New Orleans Saints defense should get him off to a strong start in Week 1.
Drew Brees gets the fourth-worst pass defense in the league from last season in Week 1, but does it without Jimmy Graham as the Saints take on the Cardinals.
Andrew Luck and the Colts head out on the road, and they're packing new toys Andre Johnson and Frank Gore, for a Week 1 game against the Bills, whose defense will be a good test.
Ryan Tannehill tossed a career-high 27 touchdown passes in 2014, and the Washington rRedskins, the Week 1 opponent for his Miami Dolphins, allowed the most throwing touchdowns in the league last season.
Sam Bradford should be able to feast upon a weak Falcons pass defense in Week 1 as he makes his Eagles debut.
Coming off of his best season as a pro, Joe Flacco has a favorable Week 1 matchup against an average Broncos defense in a game that looks to be a track meet.
Eli Manning could be involved in a shootout in a Week 1 tilt against Dallas, who lost standout corner Orlando Scandrick late in the preseason.
Teddy Bridgewater added deep threat Mike Wallace to his arsenal this offseason, and will have a chance to attack a 49ers defense that saw end Justin Smith and linebacker Patrick Willis retire and has a four-way battle for snaps at cornerback.
Andy Dalton has a positive Week 1 match-up against a Raiders defense that had difficulty against the pass last season, but his coach's ball-control system limits his upside while not improving his ability to take care of the ball.
Even without Kelvin Benjamin, Cam Newton is a solid play against the Jaguars’ 22nd ranked pass defense from last season.
Marcus Mariota performed well in the preseason, showing an accurate arm and the ability to be a pocket passer, making for an interesting match up for the Titans in Week 1 against the Buccaneers, who ranked 28th in passing yards allowed per game in 2014.
Russell Wilson faces a tough matchup against the Rams in Week 1 as Seattle's weak and inexperienced offensive line could be overwhelmed by the Rams' dominating front seven.
Blake Bortles faces a good test Week 1 against the Panthers, who ranked 11th in passing yards allowed in 2014, as we see if his offseason improvements and impressive preseason translates to the real season.
Brian Hoyer makes his Texans' debut in Week 1, but has a tough match-up with the Kansas City Chiefs and their active front seven.
Kirk Cousins faces a tough matchup against the feared front seven of the Miami Dolphins in Week 1, which could have Cousins scrambling for his life for a large portion of the contest.
Jameis Winston will face a stiff test from last season’s 15th-ranked Tennessee pass defense in his first professional game.
Matthew Stafford figures to have a stern test Sunday with the visiting Lions against a Chargers secondary that includes corners Brandon Flowers and Jason Verrett along with free safety Eric Weddle.
Nick Foles' new fantasy situation (the Rams offense hasn't finished above 23rd in total yards since 2006) and Week 1 matchup against Seattle's defense could lead to a rough debut.
Derek Carr and his new wide receivers Amari Cooper and Michael Crabtree will try to take advantage Sunday of a Bengals defense that ranked 20th last season in passing yards allowed per game.
Ryan Fitzpatrick is a career journeyman, and the Cleveland Browns had a top-10 defense last season, allowing just 21.1 points per game.
Philip Rivers has the targets to put up good numbers, but he could have little time to find them Sunday against a Lions defense that finished eighth in the league in sacks last season with 42.
Josh McCown has a good match-up against a Jets team that struggled against the pass in 2014, but the Browns may not have a strong enough attack through the air to take advantage.
Alex Smith may not have much time to find new receiver Jeremy Maclin on Sunday, as a reshuffled Chiefs offensive line struggles to contain J.J. Watt and a fearsome Texans front seven.
Tyrod Taylor is a largely unknown fantasy commodity who does possess dual-threat ability; the Buffalo Bills will certainly run a ton to take pressure off their new starting quarterback against the Indianapolis Colts on Sunday.