Jeremy Hill is the unquestioned lead back in Cincinnati, coming off a rookie season in which he exploded once entering the starting line-up, and faces a Raiders defense that was terrible against the run in 2014.
Jarvis Landry's ascension to No. 1 receiver in Miami should only be aided Sunday by a matchup with the Washington Redskins, a team that allowed a league-worst 35 touchdown passes in 2014.
Stephen Gostkowksi has been arguably the top fantasy kicker in the league over the past two seasons, and he faces a Pittsburgh Steeler defense that is in rebuilding mode.
Ben Roethlisberger, fresh off his best statistical season as a pro, will start the season in what shapes up to be a high-scoring shootout against Tom Brady and the Patriots' beatable pass defense.
Antonio Brown has an excellent match-up against a beatable Patriots defense in what looks to be a shootout between high scoring offenses.
Aaron Rodgers has a juicy matchup against a rebuilding Bears defense against which he has thrown for more than 300 yards in three straight meetings.
Matt Ryan finds himself with a plum season-opening matchup on Monday night against the Eagles’ second-worst pass defense from last season.
Tom Brady will take the field Thursday against the Pittsburgh Steelers after his suspension was overturned by a Federal Court Judge; the Steelers defense allowed 30 touchdowns through the air in 2014, which was tied for 28th in the NFL.
Julio Jones is in line for a monster week against the Eagles on Monday night, as they allowed the most points to opposing receivers last year.
Rob Gronkowski will have Tom Brady at his disposal Thursday when the New England Patriots open the season against a revamped, inexperienced Pittsburgh Steelers defense, a unit which allowed 30 touchdown passes in 2014.
A.J. Green has a great match-up against a Raiders defense that struggled against the pass in 2014, setting the stage for him to have a good game out of the gate.
Delanie Walker has been a consistent performer in his two seasons with the Titans and should continue to be in a Week 1 match-up against Tampa Bay, the NFL's 28th-ranked passing defense in 2014.
Eddie Lacy could feast on a rebuilding Bears defense which will be without their starting defensive tackle, Jeremiah Ratliff, who is suspended for three games.
Coming off of his best season as a pro, Joe Flacco has a favorable Week 1 matchup against an average Broncos defense in a game that looks to be a track meet.
Mason Crosby visits the Windy City early in the year where weather is unlikely to play a factor, and should see ample scoring chances Sunday against a rebuilt Bears defense.
Adrian Peterson looks poised to strike Monday night against a 49ers defense that is being completely rebuilt after losing middle linebacker Patrick Willis and defensive end Justin Smith to retirement.
Currently healthy, Jonathan Stewart gets a good matchup in Week 1 against a below-average Jacksonville run defense that allowed more than four yards per carry.
Greg Olsen looks like Cam Newton’s top option going into Week 1 against Jacksonville’s sub-par defense.
Cody Parkey is expected to suit up for Week 1 despite a minor leg injury suffered late in the preseason and benefits from one of the league's most effective offenses squaring off against what projects to be a poor Atlanta defense.
Doug Martin has had trouble staying on the field and being effective over the past two seasons, but gets a plus matchup against the second-worst run defense from last season in the Titans.
Dez Bryant was limited this preseason with a hamstring injury, but it's not expected to limit him in a Week 1 matchup against the Giants, a team Bryant torched for 16 catches, two scores and nearly 250 yards in a pair of meetings last season.
Sam Bradford should be able to feast upon a weak Falcons pass defense in Week 1 as he makes his Eagles debut.
DeMarco Murray gets a nice matchup in his Philadelphia debut against an Atlanta defense that was among the league's worst last season.
Randall Cobb will draw the Bears' top corner, Kyle Fuller, but with quarterback Aaron Rodgers averaging over 300 yards and four touchdowns in his last three contests against Chicago, Cobb could post a sound line Sunday.
Emmanuel Sanders figures to thrive Sunday against a Ravens defense that should force Peyton Manning to get rid of the ball quickly, but may not have the cornerbacks to keep Sanders under wraps out of the slot.
Jordan Matthews has a nice matchup in Week 1, elevated to WR1 in an up-temp offense and facing a poor Atlanta Falcons pass defense that ranked 30th last year in sacks.
Dan Bailey figures to be among the league's most consistent performers again this year, having scored between 124 and 135 points in each of his four seasons, and the Week 1 matchup against the Giants should be no different.
T.Y. Hilton, a top-six receiver in yards, yards per catch and yards per game last season, and the Colts' aerial show go on the road in Week 1 against the Bills, one of the league's top defenses in 2014.
Ryan Tannehill tossed a career-high 27 touchdown passes in 2014, and the Washington rRedskins, the Week 1 opponent for his Miami Dolphins, allowed the most throwing touchdowns in the league last season.
Andrew Luck and the Colts head out on the road, and they're packing new toys Andre Johnson and Frank Gore, for a Week 1 game against the Bills, whose defense will be a good test.
Julian Edelman is the No. 1 wideout on the defending Super Bowl champions, will have Tom Brady throwing him the pigskin Thursday and faces a Pittsburgh Steeler defense struggling to find an identity following years of supremacy.
Kicking for the Colts, who finished sixth in scoring in 2014, Adam Vinatieri will be a productive scorer this season, but has a tough Week 1 match-up on the road against the Bills, who ranked fourth in points allowed last season.
Martellus Bennett is expected to see frequent looks in new offensive coordinator Adam Gase's scheme, and with the Bears potentially without two receivers on Sunday, Bennett appears poised for heavy usage.
Davante Adams enters the season as the favorite to take over the team's second receiving role due to the season-ending injury to Jordy Nelson, and has a juicy Week 1 matchup against a retooled Bears secondary.
Carson Palmer's talented wideout trio and juicy Week 1 matchup against a shaky New Orleans Saints defense should get him off to a strong start in Week 1.
Odell Beckham gets to feast on a Dallas Cowboy secondary that he lit up for four touchdowns in his rookie season and will be without the services of standout corner Orlando Scandrick.
Frank Gore makes his Colts debut in Week 1's road game against the Bills, who ranked 11th in rushing yards allowed per game in 2014. He'll benefit greatly as the Bills need to focus on quarterback Andrew Luck.
Eli Manning could be involved in a shootout in a Week 1 tilt against Dallas, who lost standout corner Orlando Scandrick late in the preseason.
Carlos Hyde should be able to make an impact in his first start as the lead back for San Francisco against a Vikings defense that allowed the 25th-most rushing yards last year.
Matt Bryant looks to be a good option at kicker as he converted 14-of-15 field goals at home last season and should get chances in a shootout Monday night against the Eagles.
Teddy Bridgewater added deep threat Mike Wallace to his arsenal this offseason, and will have a chance to attack a 49ers defense that saw end Justin Smith and linebacker Patrick Willis retire and has a four-way battle for snaps at cornerback.
Drew Brees gets the fourth-worst pass defense in the league from last season in Week 1, but does it without Jimmy Graham as the Saints take on the Cardinals.
Mike Wallace has the speed to exploit a rebuilt 49ers secondary Monday night, though questions remain about his initial chemistry with quarterback Teddy Bridgewater.
C.J. Anderson faces a tough home matchup in Week 1 against a Ravens defense that lost nose tackle Haloti Ngata to the Lions in the offseason but still ranked fourth in rushing yards allowed per game in 2014.
Ladarius Green will get the tight end targets all to himself Sunday against an exploitable Lions linebacking corps as Antonio Gates begins a four-game suspension.
Sammy Watkins will have a new quarterback in Tyrod Taylor on Sunday against the Indianapolis Colts, but the Colts defense gave up 27 touchdowns through the air in 2014, which was in the bottom third of the league.
After ranking ninth in the NFL in scoring in 2014, Randy Bullock is secure in his position as the Texans' kicker, but the team has a tough Week 1 match-up against the Chiefs, who allowed the second fewest points in the NFL last season.
Pierre Garcon figures to get a larger share of the team targets than usual with the Miami defense expected to put pressure on Kirk Cousins, limiting the downfield looks to DeSean Jackson.
Lamar Miller is poised for a breakout season; he faces a Washington Redskins defense in Week 1 that was fairly stingy against the run in 2014, but seems to be trending in the wrong direction in 2015 after losing defensive end Junior Galette for the season.
Kendall Wright had a good preseason working with Tennessee's first-round pick, quarterback Marcus Mariota, and looks to continue that on-field rapport in Week 1 against the Buccaneers, who ranked 28th in passing yards allowed per game in 2014.