Jamaal Charles had his three-game TD streak snapped in last week's loss to the Bengals, but he has a good chance of producing multiple scores Sunday against a woeful Bears defense allowing a league-worst 31.3 points per game.
Lacy is coming off of a season-high 90 yards and faces a Rams defense that is allowing the seventh most rushing yards per game at 120.3.
Gurley exploded in the second half on the way to 146 yards rushing against the Cardinals in Week 4 and figures to see a heavy workload against a Packers defense that is yielding 115.0 rushing yards per game and 4.8 YPC (third worst in the league) in Week 5.
T.J. Yeldon is coming off the first 100-yard game of his career and may get a second in Week 5 against the Tampa Bay Buccaneers, the NFL's 30th-ranked rushing defense.
Forte is averaging 24.3 touches through four games and faces a Chiefs defense that has allowed at least 31 points in three straight games.
Dixon isn't going to break off many long gains, but he could be in for a heavy Week 5 workload against a questionable defense, as teammates LeSean McCoy (hamstring) and Karlos Williams (concussion) are both in danger of missing the game.
Murray should have some holes to run through against a soft New Orleans defense, but the entire Philadelphia offense still looks very shaky.
Lewis is averaging 15 touches per game despite the return of LeGarrette Blount, and facing a Cowboys defense that has allowed at least four catches to opposing running backs in every game this season bodes well for continued opportunities.
Blount's yardage potential is apparently capped by the presence of Dion Lewis as a receiving threat, but facing a Cowboys defense that has allowed at least one rushing touchdown in three of four games and could be without linebacker Sean Lee sets Blount up for success in Week 5.
While he may not catch 80-yard touchdown passes every week, C.J. Spiller gets a good matchup in PPR leagues against an Eagles team that's allowed more than 50 receiving yards to running backs per game.
The Houston Texans' game plan in Week 5 against the Indianapolis Colts will be to run the ball, and that means Arian Foster.
Danny Woodhead could struggle to score Monday against a Steelers defense that has allowed only one rushing TD on the season, but backs with similar skill sets such as Justin Forsett and Dion Lewis have managed big performances this year against them.
Johnson turned in a solid performance against the Rams in Week 4 (16 carries, 83 yards) but his value going forward will depend on his ability to keep his starting role with the return of Andre Ellington.
Williams struggled in his first start and is now dealing with a concussion, but the matchup is more than manageable, if he plays and LeSean McCoy (hamstring) doesn't.
Frank Gore has yet to carry the Indianapolis Colts in any game, but that could change against the Houston Texans in Week 5 when quarterback Andrew Luck is still dealing with a shoulder injury.
Lynch showed improvement as the week progressed but was ultimately held out of action in Week 4 and will have a stern test against the Bengals (85.8 rushing yards allowed per game) if he's able to return for Week 5.
Devonta Freeman may not get three rushing touchdowns for the third-straight week, but has cracked tougher defensive nuts than the Redskins, who've allowed just one rushing touchdown this season.
Doug Martin will look to build off his first 100-yard day of the season on Sunday as the Bucs take on the Jaguars, who have allowed a league-low 3.1 yards per carry.
Ellington should be back from a knee injury but another strong game from running back Chris Johnson (16 carries, 83 yards against the Rams) clouds the Arizona ground game picture in a Week 5 matchup against the Lions.
Riddick is averaging five catches through four games, giving him some appeal for an offense that is averaging a mere 47.0 yards per game on the ground.
Back atop the Washington running back heap last week, but gained just 62 yards on 17 carries.
With DeMarco Murray healthy, Sproles' workload will be hard to predict each week, and he's unlikely to get double-digit touches in any given game.
Latavius Murray will have a tough time Sunday bouncing back from a shaky Week 4 performance against a Broncos defense allowing just 90.3 rushing yards and 17.3 points per game this season.
Though possibly in line to start for the second straight week, Abdullah's Lions are averaging a league-low 47.0 yards per game on the ground, and face a Cardinals defense that did not allow more than 61 yards to an opposing back prior to Week 4.
Johnson turned 10 targets into four catches and his fourth TD of the season in a Week 4 loss but the expected return of running back Andre Ellington figures to slide him down the depth chart so he'll need to make the most of his limited touches against the Lions in Week 5.
Melvin Gordon is still looking for his first NFL touchdown after a dud performance last week against a soft Browns run defense, and now faces a Steelers unit Monday that has only given up one rushing TD all year.
Mark Ingram will look to carry over the success from his best game on the ground this season (4.5 yards per carry) in a tough matchup with the Eagles, who are allowing fewer than 100 rushing yards per game.
Ronnie Hillman ripped off a 72-yard touchdown run in Week 4 en route to a 100-yard day, but remains in a time share with C.J. Anderson and will be facing a Raiders defense Sunday allowing just 3.8 yards a carry.
Hyde was a non-factor in a loss to the Packers and draws a New York Giants rush defense that is allowing a league-best 3.1 YPC and 69.8 rushing yards per game in Week 5.
Found the end zone, but still hasn't eclipsed 13 carries in any one game despite the starters' tag.
Took a backseat after leading the Washington backfield in snaps the week prior, but could emerge again in a possible high-scoring affair against the Falcons.
Charles Sims will hope to regain his role as the primary passing-down back for the Bucs in Sunday's matchup against the Jags after being beat out by Doug Martin for the most receptions out of the backfield last week (five-to-three).
Bush could see a higher percentage of the snaps if San Francisco is forced into passing situations and will look to take advantage of the league's worst pass defense (316.3 yards per game) when the opportunity arises.
C.J. Anderson's modest Week 4 output still represented his best production of the season to date, but he'll likely need to see more targets if he wants to build on that momentum Sunday against a Raiders defense giving up over 300 passing yards a game.
McCoy would have a favorable matchup against the Titans, but he'll probably miss another week with a hamstring injury, and he might be limited even if he plays.
Bishop Sankey is the lead back in a committee in the Tennessee Titans' backfield entering a Week 5 game against the Buffalo Bills, who rank third in rushing yards allowed per game.
Has led the team with 25 carries the past two weeks, albeit for just 64 yards, and gets to face off a San Francisco 49ers defense allowing nearly 28 points a game.
A tough matchup against a Bengals defense that hasn't allowed a rushing score this season and the expected return of Marshawn Lynch should have you steering clear of Rawls in Week 5.
Knile Davis failed to receive an offensive snap for the second straight game in Week 4, but he should see a few more opportunities Sunday in a matchup against a weak Bears run defense that could require him to give Jamaal Charles the occasional breather.
Roy Helu saw his first carries of the season and scored his first touchdown last week, but touches will be scarce Sunday for Latavius Murray's main backup against a stingy Broncos defense allowing just 90.2 rushing yards per game.