Kirk Cousins is primed for another huge performance against a Browns team that's allowing 294.3 passing yards per contest, considering that he has surpassed that mark in every game this season.
Carson Palmer will look to bounce back from last week's four-interception performance Sunday against a Rams team that he carved up for over 350 yards in both 2015 meetings.
Dak Prescott has scored on the ground in back-to-back games, which makes him a solid Week 4 option against a 49ers team that has struggled to contain dual-threat quarterbacks.
Joe Flacco will be at home to take on a Raiders’ defense that he had 384 passing yards and two touchdowns against when facing them in 2015.
Matthew Stafford has topped 330 yards while throwing for three touchdowns in two games this season, and faces a Bears defense that is surrendering 27.7 points per game.
Drew Brees threw his first pick in more than 300 pass attempts on Monday night, but he'll look to get back on track in Week 4 against a Chargers defense that’s allowed 329 or more passing yards in each of the first three weeks.
Andrew Luck's overall play remains spotty to start the 2016 season, but he remains dangerous entering Week 4 as the Colts face the winless Jacksonville Jaguars, whose coach may be the first to be fired in 2016.
Andy Dalton will take on the Dolphins on Thursday night after throwing just two touchdown passes over his first three games of the season.
Blaine Gabbert's ceiling is higher than usual Sunday against a Dallas defense that just got torched for 317 passing yards by Brian Hoyer, but his floor is low as always given his game-manager role for the 49ers.
Brock Osweiler is looking to rebound from his worst effort with the Texans this week when they host the Tennessee Titans, the NFL's 12-ranked defense.
Blake Bortles' play has been a contributing factor in the Jaguars' 0-3 start, but faces a potentially big day in Week 4 against the Indianapolis Colts, who rank 27th in passing defense.
Trevor Siemian had the best game of his young career last week in Cincinnati, and could be in line for another strong performance Sunday against a Buccaneers defense that ranks 29th in QB rating allowed at 106.4.
Jay Cutler would have an inviting matchup against a Lions defense that has allowed a league-high 10 touchdown passes should he be able to return to action after missing Week 3 due to a thumb injury.
Ryan Tannehill tossed three touchdown passes last weekend and faces a Cincinnati Bengals defense that has already given up nine passing touchdowns in 2016, which is 31st in the NFL.
Cam Newton will look to shake off his first game with three interceptions since Week 7 last year against the Falcons, who’ve allowed seven passing touchdowns against one interceptions through their first two games.
Trevone Boykin threw a touchdown last week, and could be called into action Sunday against the Jets' 21st-ranked pass defense if Russell Wilson is unable to play through a sprained MCL.
Eli Manning has thrown for 925 yards through three weeks, and has the weapons to put in another effective performance despite facing Minnesota's ninth-ranked pass defense Monday.
Cody Kessler has a Week 4 matchup against a Washington defense that has allowed at least 292 passing yards in each game they’ve played this season.
Sam Bradford has been mistake free in his first two starts for the Vikings, but the team remains conservative in their play calling heading into a matchup Monday with a Giants defense that has allowed only three touchdown passes to date.
Brian Hoyer could make his second consecutive start in Week 4 against the Lions if Jay Cutler (thumb) is unable to go, and would face a defense that has allowed a league-high 10 touchdown passes through three games.
Derek Carr is coming off a quiet Week 3 and faces a tough matchup Sunday on the road against a Ravens defense that ranks eighth in QB rating allowed so far at 72.2.
Jimmy Garappolo is battling a shoulder injury, but the Pats are hopeful both he and Jacoby Brissett will be able to suit up against the Buffalo Bills this Sunday.
Ben Roethlisberger was take on this Chiefs on Sunday night, and he’ll try to be the first opposing quarterback to throw multiple touchdown passes against them.
Marcus Mariota's sophomore season hasn't been as successful as his rookie one and it only gets tougher in Week 4 against the Houston Texans, the NFL's top-ranked passing defense.
Russell Wilson will be severely limited if he's able to play through a sprained MCL Sunday against the Jets.
Alex Smith has been quiet since his big Week 1 performance, but could be surprisingly productive Sunday against a Steelers defense that's allowed the second-most passing yards in the league so far.
Jameis Winston has thrown 110 passes over the past two weeks, but will face a stiff test in Week 4 against the Broncos’ top defense against opposing quarterbacks from last season.
Tyrod Taylor threw for 475 yards, three touchdowns and three interceptions while also rushing for 44 yards and an additional score in two games last season against this weekend's opponent, the New England Patriots.
Matt Ryan didn’t throw for 300 yards for his third consecutive game against the Saints and will likely fall short once again in Week 4 versus the Panthers, who’ve allowed fewer than 180 passing yards twice this season, and have yet to allow a 250-yard passer.
Ryan Fitzpatrick is coming off an abysmal six-interception performance and will have to face off against the vaunted Seahawks defense in Week 4.
Philip Rivers failed to throw a TD in Week 3, but should be much more productive Sunday at home against a Saints defense that ranks 26th in QB rating against at 104.8.
Tom Brady will be sidelined for the final game of his Deflategate suspension as the Patriots face the Buffalo Bills.
Case Keenum threw two touchdowns last week, but repeating that task will be a tall order against a Cardinals defense that's allowing just 189.0 passing yards per game.
Jacoby Brissett is battling a thumb injury, but the Pats are hopeful both he and Jimmy Garappolo will be able to suit up against the Buffalo Bills this Sunday.