49ers head coach Kyle Shanahan said WR Brandon Aiyuk "would've got his spot completely back" if not for a hamstring injury before the team's final preseason game. 

Advice: Shanahan said the Niners "planned on rotating" Aiyuk with WR Trent Sherfield in Week 1 "and you get a big reaction to that." "It's not personal," he said. "Things are a bigger deal because of fantasy football." At least Shanahan knows his roster decisions are triggering millions of fantasy managers. With a full practice on Wednesday, Aiyuk appears recovered from the hamstring issue he dealt with since the end of August. Aiyuk will be impossible to trust for fantasy purposes unless we get more clarifying reports before the 49ers play the Eagles on Sunday.  NBCSportsEDGE.com 21 minutes ago

Bills head coach Sean McDermott said RB Zack Moss was inactive in Week 1 due to health concerns and that Moss has "looked good" in practice this week. 

Advice: Moss struggled through some August injuries and was a scratch for Buffalo's Week 1 loss to the Steelers. Devin Singletary played 75.2 percent of the Bills' offensive snaps and saw 11 carries for 72 yards and three catches for eight yards. Moss' return to the lineup will cap Singletary's usage in Week 2 against the Dolphins. Last year, Singletary averaged 8.7 rushing attempts and three targets per game when Moss was active. Both Singletary and Moss will be iffy RB3/4 options this week.  NBCSportsEDGE.com Today, 8:42 am

49ers offensive coordinator Mike McDaniels said RB Trey Sermon will be active for Week 2 against the Eagles. 

Advice: McDaniels said Sermon displayed "extra aggressiveness" in practice this week after being a shocking healthy scratch in Week 1 against Detroit. "Kyle [Shanahan] always says to the players and coaches, ‘Don’t tell me, show me.’ And (Sermon) showed, I think, all of us that he really wants an opportunity, which he’ll get this Sunday," McDaniels said. Sermon apparently did enough to exit Shanahan's cavernous doghouse, though he'll likely play behind Elijah Mitchell a week after Mitchell rushed 19 times for 104 yards and a touchdown. Raheem Mostert out with a knee injury opens a narrow path for Sermon to see touches in the coming weeks. He should be stashed in 12-team leagues.  NBCSportsEDGE.com Today, 7:57 am

Kadarius Toney did not receive a touch in the Giants' Week 2 loss to Washington. 

Advice: Toney and fellow wideout Kenny Golladay were visibly upset on the sideline Thursday night while the Giants went back and forth with Washington. Toney, who played 19 snaps Thursday night, stormed off after head coach Joe Judge pulled him aside in the third quarter and spoke to him briefly. After the game, Toney posted to Instagram: “i don’t be mad, s—t just be lame to me." The 20th overall pick in the 2021 NFL Draft missed most of training camp with COVID-19 and was hardly utilized in New York's opener against Denver, catching both of his targets for -2 yards. Toney should only be rostered in the deepest fantasy formats.  NBCSportsEDGE.com Today, 5:21 am

Logan Thomas caught 5-of-7 targets for 45 yards in Washington's Week 2 win over the Giants. 

Advice: Thomas has been gobbling up snaps but has only 8/75/1 to show for it through two games. Reserve Ricky Seals-Jones managed to haul in a go-ahead fourth quarter touchdown this evening. It stands to reason Thomas' targets will increase as soon as he get comfortable with fill-in QB Taylor Heinicke, who has few other places to go outside of Terry McLaurin. Thomas' snap counts and target upside will keep him in the top 10 at tight end, including for Week 3 against Buffalo.  NBCSportsEDGE.com Yesterday, 9:42 pm

Darius Slayton caught 3-of-6 targets for 54 yards and a touchdown in the Giants' Week 2 loss to Washington.

Advice: Slayton's touchdown was a 33-yarder where he ran right by William Jackson III. He could have had an even bigger night after coming open for a would-be 43-yard score on a blown coverage, but he committed a "drop" on a Daniel Jones pass that was ever so slightly overthrown. Both were to blame. Slayton struggled with drops in Week 1, though he has so far remained Jones' preferred deep target even with Kenny Golladay on the roster. The Falcons' talent-less defense is on tap for Week 3.  NBCSportsEDGE.com Yesterday, 9:38 pm

J.D. McKissic caught 5-of-6 targets for 83 yards in Washington's Week 2 win over the Giants, adding four rushes for 10 additional yards. 

Advice: McKissic came back to life this evening after Antonio Gibson out-touched him 23-1 in Week 1. Gibson's advantage was a more modest 15-9 against the Giants, while McKissic won the yardage war 93-73. That was largely due to a 56-yard reception in the fourth quarter where McKissic faked to the flat before jutting up the sideline and coming completely wide open. Six targets isn't blowing the doors off, but it has complicated the post-Week 1 narrative heading into a tough matchup with the Bills. Gibson still has a ways to go to cut into McKissic's advantage on third downs and in the two-minute drill. Meanwhile, McKissic having seven targets through two games isn't exactly screaming PPR FLEX.   NBCSportsEDGE.com Yesterday, 9:28 pm

Terry McLaurin caught 11-of-14 targets for 107 yards and a touchdown in Washington's Week 2 win over the Giants. 

Advice: This was the kind of effort McLaurin provided several times early last season before injury and quarterback issues took hold. The 11 catches were a new career high. Fill-in starter Taylor Heinicke decided on a McLaurin-or-bust strategy after a quiet first quarter and McLaurin responded with one critical chain-moving grab after another. He is far and away the most important weapon in this passing attack, and Heinicke was able to make that critical determination on only three days' rest coming out of his Week 1 relief appearance. The duo should continue to hook up for a targets bonanza, stabilizing McLaurin's WR1 value. He does face a stiff Week 3 test in Tre'Davious White and the Bills.  NBCSportsEDGE.com Yesterday, 9:18 pm

Daniel Jones completed 22-of-32 passes for 249 yards and a touchdown in the Giants' 30-29, Week 2 loss to Washington, adding nine carries for 95 additional yards and a touchdown. 

Advice: Crazy Legs Jones was the story of the evening for the G-Men, but it still wasn't enough in yet another devastating defeat for an accursed organization. Jones appeared to have a 58-yard rushing touchdown in the second quarter on a read option keeper, but a ticky tack holding penalty turned it into merely a 46-yard gain. The Giants then, unsurprisingly, settled for a field goal. For the rushing score he did convert, Jones cashed in a quarterback draw. As a passer, Jones was under siege in the first half before finding more time after the break. He nearly turned it into a 43-yard touchdown strike to Darius Slayton, but the receiver could not corral a ball thrown inches too far. It will be labeled a drop, but it should have been a better pass. The touchdown Jones did convert was a 33-yard strike to Slayton in the third frame, where the wideout simply ran by William Jackson III. Elsewhere, Jones' timing looked off with Kenny Golladay, and the high-dollar free agent addition was spotted yelling at Jones on the sideline. He had a point. Jones has 10 days to lick his wounds before a golden matchup in the Falcons. Up to 122 yards rushing through two starts, Jones is punching way above his weight as a fantasy option. It will be hard to keep him out of the QB1 streamer mix for Week 3.  NBCSportsEDGE.com Yesterday, 8:56 pm

Texans TE Pharaoh Brown (ankle, shoulder) remained sidelined on Thursday. 

Advice: The Texans' No. 1 pass-catching tight end if Week 1's usage is to be believed, Brown is now in real danger of sitting against the Browns. If he can get out there, there would be targets for the taking in a contest where the Texans are nearly two-touchdown road 'dogs. Jordan Akins is the next man up in the seam.  NBCSportsEDGE.com Yesterday, 4:23 pm