Rob Gronkowski will have Tom Brady at his disposal Thursday when the New England Patriots open the season against a revamped, inexperienced Pittsburgh Steelers defense, a unit which allowed 30 touchdown passes in 2014.
Greg Olsen looks like Cam Newton’s top option going into Week 1 against Jacksonville’s sub-par defense.
Delanie Walker has been a consistent performer in his two seasons with the Titans and should continue to be in a Week 1 match-up against Tampa Bay, the NFL's 28th-ranked passing defense in 2014.
Martellus Bennett is expected to see frequent looks in new offensive coordinator Adam Gase's scheme, and with the Bears potentially without two receivers on Sunday, Bennett appears poised for heavy usage.
Jimmy Graham should continue to see plenty of red zone targets in a Week 1 matchup against the Rams, even with the move to the run-friendly Seahawks offense.
Marcedes Lewis becomes the top tight end target in Week 1 against Carolina as free-agent acquisition Julius Thomas (finger) will miss the first two games of the season.
Austin Seferian-Jenkins, finally healthy, will provide a good option underneath for Jameis Winston in his first career start against a Titans team that allowed the eighth-most points to opposing tight ends last season.
As a top-five touchdown-maker among tight ends in 2014, Dwayne Allen may benefit from quarterback Andrew Luck's red-zone tendency for targeting tight ends in the Colts' Week 1 meeting against the Bills.
Tyler Eifert has the skill set and opportunity to produce good numbers this year, and in Week 1 he has a favorable match-up against a Raiders defense that struggled against the pass in 2014.
Jordan Reed could be a sneaky third option in the passing game against a Miami team that figures to apply enough pressure up front, limiting the downfield looks for Kirk Cousins and resulting in some check-down looks for Reed.
Benjamin Watson will look to fill the void left by Jimmy Graham in this plus Week 1 matchup against the Cardinals, who allowed the fifth-most fantasy points to opposing tight ends last season.
Vernon Davis' quest to erase last year's nightmare may get off to a slow start against a stingy Vikings defense, which allowed the seventh-fewest passing yards last year.
Maxx Williams has a solid match-up against a beatable Broncos pass defense, and even though he is second on the depth chart at tight end his good receiving skills could get him on the field enough to produce some sneaky numbers in Week 1.
Darren Fells appears set to open the season as the Cardinals' primary tight end and has an exploitable matchup against a shaky Saints defense in Week 1.
Jason Witten needs to find the end zone to have much value, something he did just five times last year, albeit one of those touchdowns came against Week 1's opponent, the New York Giants.
Eric Ebron could exploit matchups against Chargers linebackers Manti Te'o and Denzel Perryman in Week 1, but a time share with blocker Brandon Pettigrew will likely limit Ebron's opportunities.
Crockett Gillmore is in a platoon with Maxx Williams, but could play a large role in a likely high-scoring game against the Broncos in which the Ravens only have one proven receiving threat on the outside in Steve Smith.
Travis Kelce faces a difficult matchup Sunday against a Texans defense that allowed just 33 receiving yards a game and four touchdowns to tight ends during the 2014 season.
Kyle Rudolph enters the year healthy after playing in 17 total games over the last two seasons, and could provide the Vikings with a bigger red zone target against a vulnerable 49ers secondary Monday night.
Richard Rodgers could garner additional looks in Week 1 against the Bears with receiver Jordy Nelson sidelined for the season, but just how much could cause owners some anxiety for a player who tallied only 20 catches a year ago.
Brent Celek could find himself on the field for more snaps than usual if nominal starting tight end Zach Ertz is unable to answer the bell in Week 1 due to injury.
Jeff Cumberland caught just two touchdown passes last year, his quarterback situation is no better in 2015, and the New York Jets face a Cleveland Browns defense that was rather stingy against the pass in 2014.
Jared Cook should have a more reliable signal caller in Nick Foles, but a Week 1 matchup against the Seahawks won't help his chances.
Charles Clay is learning a new offense, that will focus on running the football, and has a new quarterback to develop a rapport with, both which will make his impact Sunday against the Indianapolis Colts unless he can find the end zone.
Mychel Rivera could see few targets Sunday as Derek Carr focuses his attention on new acquisitions Amari Cooper and Michael Crabtree, assuming a rejuvenated Bengals front seven gives Carr time to look downfield.