Zack Moss has rushed for 220 yards over the Colts' past three games, and he'll have a nice opportunity to close the season out on a high note as the lead back in Week 18 against a Texans defense that's been gashed for league highs in yards (2,262) and touchdowns (21) on the ground by running backs.

Andy Dalton has failed to throw for multiple touchdowns in four of his last five games as the Saints head into a Week 18 matchup against a Panthers defense that has allowed the most fantasy points per game to opposing quarterbacks across the last five weeks.

Greg Zuerlein has missed six of his 34 field-goal attempts this season for the Jets, and in Week 18, he'll get a Miami defense that has given up 24.6 points per game in 2022, the sixth-highest total in the league.

Patrick Mahomes has already posted his second career season with 5,000 passing yards and 40 touchdowns, and with the top seed in the AFC in Kansas City's sights, he's unlikely to slow down in Week 18 against a Raiders defense he lit up for 292 yards and four TDs in their first meeting this season.

Travis Kelce hasn't found the end zone in five straight games, but that drought could end in Week 18 as Kansas City faces a Raiders defense he torched for four TDs in their first meeting this season.

Ja'Marr Chase has put up at least 97 yards or scored in five of his last six outings for the Bengals, and in Week 18, he'll get a Baltimore defense that has allowed 169.9 yards per game to wide receivers in 2022, the fifth-highest total in the league.

Miles Sanders has been held out of the end zone and under 70 yards rushing in each of the last three games for the Eagles but will face a Giants squad in Week 18 that may be resting starters, and even if not, the Giants have been suspect against the run all season, surrendering 144.8 yards per tilt on the ground, which is 28th in the NFL.

Tyler Higbee has fewer than 28 yards in five of the Rams' last six games, but the fact he's scored three touchdowns over the last three games makes him a player to consider as a fantasy starter in a Week 18 matchup against a Seahawks defense that's allowed over 70 yards per game and the most fantasy points to opposing TEs.

Despite receiving consistent opportunity, Cade Otton has recorded two or fewer receptions in each of his last three games as Tampa Bay heads into a Week 18 matchup against an Atlanta defense that has allowed the fifth-most fantasy points per game to opposing tight ends.

Mike White has thrown four interceptions and no touchdowns over his last three starts for the Jets, and in Week 18, he'll get a Miami defense that has given up 24.6 points per game in 2022, the sixth-highest total in the league.

Latavius Murray turned 16 touches into 72 yards last week as the Broncos' top option out of the backfield, and he may not need much of a workload to be productive in Week 18 against a vulnerable Chargers defense that just got gashed for 123 rushing yards by Cam Akers.

DeAndre Hopkins missed Arizona's last game with a knee injury, and his availability may be in doubt going into a Week 18 matchup against a 49ers defense that's allowed one touchdown per game and the sixth-most fantasy points to opposing WRs.

Aaron Jones has 90+ yards in two of three games since the Packers' bye, but has only two touchdown rushes all year entering a Week 18 matchup against a Detroit defense that's allowing 5.3 ypc, the second-highest total in the league, and 22 rushing scores to date, the third-highest mark.

David Njoku has topped 30 yards just once in his past six outings for the Browns, and in Week 18, he gets a Pittsburgh defense that has given up 52.2 passing yards per game to tight ends so far in 2022, the 11th-highest total in the league.

Isiah Pacheco has reached 90 scrimmage yards or scored a touchdown in seven straight games, giving the Kansas City rookie a strong floor heading into a Week 18 clash with a Raiders defense that's allowed the sixth-most scrimmage yards to running backs this season.

Gerald Everett got into the end zone last week for the first time since early October, but he could be productive again in Week 18 as the Chargers face a Broncos defense that ranks in the bottom four in catches and yards allowed to tight ends.

Evan Engram cooled down with a one-catch effort last week after totaling 26 catches over the previous three games, including a career-best 11 catches for 162 yards and two touchdowns against the Titans, whom the Jaguars will host in Week 18 with a playoff berth on the line.

DeVonta Smith has at least 100 yards receiving or a touchdown in each of the last six games for the Eagles and will face a Giants squad in Week 18 that may be resting starters, though allowed just 21 passing scores this season, which is tied for 10th in the NFL.

Damiere Byrd has one or fewer receptions in each of his last five games as the Falcons head into a Week 18 matchup against a Tampa Bay defense that has allowed the eighth-most fantasy points per game to opposing wide receivers.

Cairo Santos has multiple made field goals in just two of the Bears last nine games, but gets a Vikings defense in Week 18 that's allowed double-digit points to eight-straight opposing kickers.

Tyquan Thornton is coming off a season-high 60 receiving yards for the Patriots, who in Week 18 get a Buffalo defense that has allowed 160.3 passing yards per game to wide receivers in 2022, the eighth-highest total in the league.

Mike Gesicki has seen inconsistent opportunities when Durham Smythe has been healthy for the Dolphins, but in Week 18, they'll get a Jets defense that has given up 59.6 passing yards per game to tight ends so far in 2022, the seventh-highest total in the league.

Marquise Brown hasn't scored a touchdown for the Cardinals since Week 5, but he'll look to get back on track in a Week 18 matchup against a 49ers defense that's allowed one touchdown per game and the sixth-most fantasy points to opposing WRs.

A.J. Brown has at least 100 yards receiving or a touchdown in each of the last six games for the Eagles and will face a Giants squad in Week 18 that may be resting starters, though allowed just 21 passing scores this season, which is tied for 10th in the NFL.