Le’Veon Bell will take on the Browns this Sunday, but there’s a strong possibility that the team will rest him, as the Steelers have clinched the third spot in the AFC, making this a meaningless game.
Jordy Nelson has multiple touchdown catches in two of his last three games entering Sunday night's showdown for the NFC North crown against the Lions, a defense he put 101 yards and two scores up against in a Week 3 meeting.
Antonio Brown will have a Sunday tilt against the Browns, but it’s very possible that the team will significantly limit his playing time, due to the fact that the Steelers have clinched the third seed in the AFC playoffs.
Sterling Shepard has scored six times in his past eight games, and has a good chance of finding the end zone once again Sunday against the 27th-ranked Redskins pass defense.
Michael Thomas is just 19 yards away from 1,000 yards in his rookie season, and leads all rookies in receptions, yards, touchdowns and any other receiving category you can think of; he's nearly a lock to reach his milestone Sunday against the Falcons.
Brandon LaFell will have a Sunday tilt against the Ravens after posting at least 91 receiving yards and three of his last four games.
Julian Edelman needs 45 receiving yards on Sunday for the second 1,000-yard season of his career, and will face a Miami Dolphins defense allowing 240 passing yards per contest, which is 13th in the NFL.
Eli Rogers will face the Browns in Week 17, after averaging 79.5 yards along with one touchdown over his last two contests.
DeSean Jackson has topped 100 yards in four of his past five games heading into Sunday's crucial matchup against a Giants team he loves to face.
Thomas Rawls is expected to be back from last week's shoulder bruise in time to exploit San Francisco's league-worst rushing defense in Week 17.
Cameron Meredith has scored or topped 100 yards in three straight games, seeing 33 targets in that span entering Sunday's season finale against a Vikings defense that has allowed six touchdown passes in the last two weeks.
LeSean McCoy has four 100-yard games in his last five contests while scoring six touchdowns over that span, and will face a reeling New York Jets rushing defense in Week 17 that's allowing over 100 yards per game on the ground this season.
LeGarrette Blount scored two touchdowns last weekend, but faces a Miami defense in Week 17 that's allowed only 11 scores on the ground in 2016, which is tied for 12th in the NFL.
Mark Ingram is just 60 yards away from his first 1,000-yard season, and faces a Falcons defense on Sunday that’s allowed the eighth-most yards per attempt this season.
Odell Beckham has 504 yards and four touchdowns over the past five weeks, and will look to stay hot Sunday against cornerback Josh Norman and the 27th-ranked Redskins pass defense.
Mike Evans will look to cap off his career year against a Panthers secondary on Sunday that’s allowed a league-worst 291 receiving yards per game.
Sammy Watkins is coming off his first 100-yard game of the season, and will face a suspect Jets secondary on Sunday that's allowing 249 passing yards per game, which is 20th in the league.
Adam Thielen has at least 86 yards in three of his last four games and has emerged as the Vikings top receiving threat entering a Week 17 finale against a Bears secondary that has allowed three receivers to top 93 yards in the last two games.
Brandin Cooks has 24 receptions for 418 yards over his past four games since turning in a duck against the Rams, but faces a Falcons secondary in Week 17 that held him to two receptions and eight yards in Week 3.
Marqise Lee looks to finish off a breakout season in Week 17 against the Indianapolis Colts' 25th-ranked rushing defense 273.7 ypg).
Jordan Howard has at least 99 total yards in eight straight games, a streak that started in his first matchup with Sunday's opponent, the Minnesota Vikings, whom he gashed for 153 yards and a score on 26 carries.
Doug Baldwin just burned Arizona for 13 catches and 171 yards last week, so a strong encore is likely Sunday against a 49ers defense that has allowed a league-worst 30.3 points per game.
T.Y. Hilton looks to finish out a nice bounce-back season in Week 17 when the Indianapolis Colts face the three-win Jacksonville Jaguars, who rank sixth in yards allowed per game to wideouts (144.7 ypg).
David Johnson has found pay dirt 20 times this season, and will be motivated to add to that total Sunday against a Rams team that surprisingly kept him from scoring back in Week 4.
Bilal Powell should see the bulk of the carries Sunday against the Buffalo Bills, whose defense is allowing a subpar 133.5 rushing yards per game.
Davante Adams has only six catches and 69 yards over the last two weeks entering a matchup against a Lions secondary that has not allowed more than 212 yards passing in three straight games.
DeAndre Hopkins' production didn't change with the quarterback switch from Brock Osweiler to Tom Savage, so we should expect a run-first attack out of the Houston Texans in Week 17 against the Tennessee Titans.
Willie Snead has more than 800 receiving yards despite being the Saints’ third receiver, but that role makes him more of a toss-up than the two above him on the depth chart as he’s still liable for two reception, 21 yard clunkers like last week when he plays the Falcons in Week 17.
Golden Tate has at least six catches in four straight games entering a season finale matchup with Green Bay's 29th ranked pass defense that allows 265 yards per game.
Jeremy Maclin was held in check last week by the Broncos' secondary, but should be more productive Sunday against a Chargers defense that he found the end zone against in Week 1.
Tyler Boyd will face the Ravens on Sunday after catching five passes for 62 yards in his last meeting against them.
DeVante Parker posted 85 yards and a touchdown last weekend, and will face a New England defense on Sunday that's allowing 240 passing yards per game, which is 14th in the NFL.
Jarvis Landry had a two-game streak of 100-yard outings snapped last weekend, and will face a New England defense in Week 17 that's allowing 240 passing yards per tilt, which is 14th in the league.
Allen Robinson is coming off his best game of the season and looks to build off that in Week 17 against the Indianapolis Colts, who rank 18th in yards allowed per game to wideouts (160.8 ypg).
Darren Sproles should get plenty of touches Sunday against the Cowboys, as he and Byron Marshall are the only healthy Eagles running backs left.
Injuries to T.J. Yeldon (ankle) and Chris Ivory (hamstring) make Grant a possible lead back for Week 17 against the Indianapolis Colts, who rank 23rd in rushing defense (116.3 ypg).
Tyreek Hill failed to catch any of his five targets last week but scored his third rushing TD in five games, and the Chiefs should be committed to getting the ball in his hands once again Sunday as they look to keep their chances of an AFC West title alive.
The beneficiary of another healthy scratch of Doug Martin, Jacquizz Rodgers will look to run wild on Sunday against a Panthers defense Rodgers shredded for 101 rushing yards in Week 5.
Alex Collins will serve as the primary running back against the league-worst 49ers run defense Sunday if Thomas Rawls (shoulder) can't suit up, but Rawls is expected to play.
Kelvin Benjamin snapped his cold streak (five receptions for 49 yards over his previous three games) to catch his second touchdown since Oct. 2, but the Panthers’ passing game makes him tough to trust on Sunday against the Bucs, even as they’ve allowed the 10th-most receiving yards in the league.
If the Tennessee Titans choose to rest or limit DeMarco Murray in a game that has no playoff implications, Derrick Henry could get the bulk carries in Week 17 against the Houston Texans.
The Tennessee Titans, with playoff hopes dashed last week, could limit DeMarco Murray in Week 17 against the Houston Texans.
Steve Smith will be up against the Bengals in Week 17 after averaging 57 yards while scoring two touchdowns over his last four games.
Jordan Matthews is battling through an ankle injury, but should still be able to find success against a 28th-ranked Cowboys secondary that has allowed 264.7 passing yards per game.
Alshon Jeffery has at least eight target in six straight games and is averaging 90.5 yards in his two games since returning from suspension, seemingly giving him a safe floor even if he's matched up exclusively with Vikings corner Xavier Rhodes on Sunday.
Charles Sims saw just seven touches against the Saints last week, despite Doug Martin being a healthy scratch, and with him out again, look for him to see more work in the passing game this weekend as Devonta Freeman caught eight passes last week against the Panthers.
Kenneth Dixon will have a Week 17 matchup against the Bengals, who he posted 80 total yards against in Week 13.
Ty Montgomery has at least 12 touches in three straight games, but faces a Lions defense on Sunday that has allowed opposing backs to score only five times this year, and only six backs to top 70 yards.
Latavius Murray was held to just 40 yards last week, but should rebound Sunday against a Broncos defense he torched for 114 yards and three TDs in Week 9.
Robert Turbin is tied for second on the Indianapolis Colts with seven touchdowns (six rushing, one receiving) and has scored four times in the last four games entering Week 17 against the Jacksonville Jaguars, who rank 23rd in rushing touchdowns allowed.