Le’Veon Bell will take on the Browns this Sunday, but there’s a strong possibility that the team will rest him, as the Steelers have clinched the third spot in the AFC, making this a meaningless game.
LeSean McCoy has four 100-yard games in his last five contests while scoring six touchdowns over that span, and will face a reeling New York Jets rushing defense in Week 17 that's allowing over 100 yards per game on the ground this season.
Thomas Rawls is expected to be back from last week's shoulder bruise in time to exploit San Francisco's league-worst rushing defense in Week 17.
Bilal Powell should see the bulk of the carries Sunday against the Buffalo Bills, whose defense is allowing a subpar 133.5 rushing yards per game.
Jordan Howard has at least 99 total yards in eight straight games, a streak that started in his first matchup with Sunday's opponent, the Minnesota Vikings, whom he gashed for 153 yards and a score on 26 carries.
David Johnson has found pay dirt 20 times this season, and will be motivated to add to that total Sunday against a Rams team that surprisingly kept him from scoring back in Week 4.
Mark Ingram is just 60 yards away from his first 1,000-yard season, and faces a Falcons defense on Sunday that’s allowed the eighth-most yards per attempt this season.
The Tennessee Titans, with playoff hopes dashed last week, could limit DeMarco Murray in Week 17 against the Houston Texans.
Robert Turbin is tied for second on the Indianapolis Colts with seven touchdowns (six rushing, one receiving) and has scored four times in the last four games entering Week 17 against the Jacksonville Jaguars, who rank 23rd in rushing touchdowns allowed.
The beneficiary of another healthy scratch of Doug Martin, Jacquizz Rodgers will look to run wild on Sunday against a Panthers defense Rodgers shredded for 101 rushing yards in Week 5.
Injuries to T.J. Yeldon (ankle) and Chris Ivory (hamstring) make Grant a possible lead back for Week 17 against the Indianapolis Colts, who rank 23rd in rushing defense (116.3 ypg).
Latavius Murray was held to just 40 yards last week, but should rebound Sunday against a Broncos defense he torched for 114 yards and three TDs in Week 9.
Charles Sims saw just seven touches against the Saints last week, despite Doug Martin being a healthy scratch, and with him out again, look for him to see more work in the passing game this weekend as Devonta Freeman caught eight passes last week against the Panthers.
Jay Ajayi is coming off yet another 200-yard game, but will face a New England defense on Sunday that's allowing just 89.5 yards per game on the ground, which is third in the NFL.
Alex Collins will serve as the primary running back against the league-worst 49ers run defense Sunday if Thomas Rawls (shoulder) can't suit up, but Rawls is expected to play.
Ty Montgomery has at least 12 touches in three straight games, but faces a Lions defense on Sunday that has allowed opposing backs to score only five times this year, and only six backs to top 70 yards.
Devontae Booker set career highs in targets, catches and receiving yards last week, and could see a larger workload Sunday against the Raiders with the Broncos eliminated from the playoffs and in talent evaluation mode.
Alfred Blue is in line to be the Houston Texans' lead back if they decide to limit Lamar Miller (ankle) for a second straight game in Week 17 against the Tennessee Titans' fifth-ranked rushing defense (91.1 ypg).
Jerick McKinnon has four yards or better per carry in three of his last four games while catching at least five passes in each of those outings, giving him some surprising upside against a Bears defense that has allowed seven rushing scores in their last two outings.
Kenneth Dixon will have a Week 17 matchup against the Bengals, who he posted 80 total yards against in Week 13.
Rex Burkhead will take on the Ravens this Sunday, and he could be in for an expanded role if Jeremy Hill is limited or inactive due to the knee injury he battled through last week.
If the Tennessee Titans choose to rest or limit DeMarco Murray in a game that has no playoff implications, Derrick Henry could get the bulk carries in Week 17 against the Houston Texans.
Jonathan Stewart saw just 11 carries against the Falcons as they were playing catch-up all game, and while this Sunday's opponent, the Bucs, have allowed the ninth-most rushing yards, they'll be playing for their playoff lives.
Darren Sproles should get plenty of touches Sunday against the Cowboys, as he and Byron Marshall are the only healthy Eagles running backs left.
Frank Gore has been losing snaps and red-zone touches to Robert Turbin entering the Indianapolis Colts' Week 17 matchup against the Jacksonville Jaguars' 20th-ranked rushing defense (107.3 ypg).
Terrance West will be up against the Bengals on Sunday after posting at least 53 total yards in seven of his last eight games.
Charcandrick West saw double-digit touches last week for the first time since Week 9 due to Spencer Ware's rib injury, and could see a similar workload Sunday as the Chiefs look to keep their chances of an AFC West title alive.
Zach Zenner was on the right side of a time share last week with Dwayne Washington, but his role for Week 17 against Green Bay's ninth-ranked rush defense will depend on the health of Theo Riddick (wrist).
Paul Perkins will split carries with Rashad Jennings in Washington on Sunday.
Rob Kelley remains the primary running back in Washington heading into Sunday's matchup with the seventh-ranked Giants defense.
Ezekiel Elliott has already amassed 322 carries in his tremendous rookie season, and is likely to see a significant reduction in work for rest purposes Sunday against the Eagles.
The Houston Texans, who have clinched a berth in the postseason, will be smart when it comes to a potential role for Lamar Miller (ankle) in Week 17 against the Tennessee Titans' fifth-ranked rushing defense (91.1 ypg).
Alfred Morris will see more carries than usual Sunday in Philadelphia with Ezekiel Elliott likely to spend msot of the game resting in preparation for the playoffs.
James White scored his first touchdown since November 20th last weekend, and will face a Miami Dolphins defense in Week 17 that's allowed 27 passing scores in 2016, which is tied for 25th in the league.
Shaun Draughn will take over primary running back duties Sunday against the Seahawks with Carlos Hyde (knee) out.
Chris Ivory's hamstring injury leaves him questionable entering Week 17 against the Indianapolis Colts' 23rd-ranked rushing defense (116.3 ypg).
Dion Lewis has 34 rushes in his last two games, but continues to cede goal line touches to LeGarrette Blount, though he should continue to be involved in the rushing attack on Sunday against the Dolphins.
Isaiah Crowell will face the Steelers in Week 17 after being held to 10 rushing yards on eight carries when he faced them six weeks ago.
Todd Gurley closes out his subpar 2016 campaign Sunday against a Cardinals front that held him to 33 yards on 19 carries back in Week 4.
Melvin Gordon practiced without a knee brace this week, and could return to the lineup Sunday as the Chargers look to spoil the Chiefs' chances of winning the AFC West title.
Mike Gillislee rushed for a season-high 91 yards last week,but will remain behind LeSean McCoy on the depth chart in Week 17 against a New York Jets rushing defense allowing 100.9 yards per contest on the ground.
Byron Marshall will get most of the rushing workload Sunday against the top-ranked Dallas run defense with Ryan Mathews out due to a herniated disc.
Spencer Ware is battling a rib injury, but is expected to start Sunday against a Chargers team he lit up for 199 yards from scrimmage back in Week 1.
Duke Johnson will have a Week 17 tilt against the Steelers after posting at least 45 total yards in each of his last three games.
Theo Riddick has missed three games due to a wrist injury and even if he suits up, he'll carry plenty of risk into Sunday night's game against a Green Bay defense that limited him to 48 total yards back in Week 3.
Carlos Hyde's knee injury ended his season a game early ahead of Sunday's showdown with the Seahawks.
T.J. Yeldon (ankle) has been placed on season-ending injured reserve.
Doug Martin will be inactive for the season finale against the Panthers.
Adrian Peterson did not play last week due to groin and knee injuries, and has little incentive to suit up in Week 17 against the Bears with the Vikings eliminated from playoff contention.
Ryan Mathews will miss the season finale against Dallas with a herniated disc.