Russell Wilson came alive with four touchdown passes last week and is capable of finding similar success if called upon to do so Sunday against a Colts defense that's allowing 283.7 passing yards per game.
A.J. Green caught 10 of 13 targets for 111 yards and a touchdown last Sunday against the Green Bay Packers, the best game of the season for Green and the entire Cincinnati Bengals offense, and this Sunday he faces a Cleveland Browns defense that was torched for 153 yards and a touchdown by T.Y. Hilton in their last game.
Odell Beckham will have a Sunday tilt against the Buccaneers, who were ambushed by the top-two Vikings receivers for 271 yards and two touchdowns last week.
Ezekiel Elliott will have a Sunday tilt against the Rams to face a defense that’s given up four touchdowns to opposing running backs over their last two games.
Jarvis Landry will face the Saints in Week 4, who gave up 157 yards to fellow slot receiver Adam Thielen in Week 1.
Jimmy Graham reestablished himself as the No. 2 option in Seattle's passing game last week, just in time to take advantage of Indianapolis' 29th-ranked pass defense Sunday.
DeVante Parker will have a Sunday tilt against the Saints, who have allowed at least 68 receiving yards to four different wide receiver to start the season.
Michael Thomas has yet to have a standout game, but his consistency (he’s caught five or more balls and seen eight or more targets in every game this season) makes him a top option against the Dolphins’ secondary that’s allowed the fifth most passing yards this season.
Todd Gurley has scored six touchdowns in three weeks and will likely get right back into the end zone Sunday in Dallas.
Aaron Rodgers has opened the year with three straight 300-yard games and faces a Bears defense Thursday which he averaged 289 yards against last year while throwing for three scores.
Christian McCaffery saw a team-high 11 targets last week and is going up against a Patriots defense in Week 4 that’s been shred by pass-catching backs all season (Kareem Hunt’s in Week 1, Alvin Kamara in Week 2 and D’Onta Foreman in Week 3).
Dez Bryant will take on the Rams in Week 4 after this defense gave up 208 yards on just 10 receptions to the starting outside receivers of the San Francisco 49ers in last week’s game.
Devin Funchess saw double-digit targets for the first time in his career last week and could make that a regular occurrence if Kelvin Benjamin is forced to miss time and takes on a Patriots secondary in Week 4 that’s allowed more than 300 passing yards every week this season.
Coby Fleener has been inconsistent this season, catching both of his touchdowns late in blowouts, he faces a Dolphins defense that’s allowed 14 receptions to opposing tight ends in just two games this season including Hunter Henry’s seven receptions for 80 yards in Week 2.
Tarik Cohen leads the Bears in receptions and has 44 touches through three weeks, and that volume makes him a trustworthy option against a Packers 21st ranked run defense on Thursday.
Mason Crosby has only four field goals through three weeks, but could be busy Thursday against a Chicago defense that allows 23 points and has seen two of three opposing kickers drill three field goals.
Doug Baldwin (groin) should have field day Sunday against the 29th-ranked Colts pass defense assuming he suits up after exiting last week's game in the fourth quarter.
Carlos Hyde scored two touchdowns last week and should once again be San Francisco's most reliable source of yardage Sunday in Arizona.
Jay Ajayi will take on the Saints this Sunday after they’ve allowed just one running back to find the end zone over the first three games of the season.
Stefon Diggs has at least five catches in seven of his last eight home games, including a 13-catch outing against Detroit last year, making him a high-potential option regardless of who is under center for the Vikings on Sunday.
Blair Walsh will likely be kept busy in Sunday's prime time home tilt against the Colts.
Drew Brees had fewer than 30 pass attempts for just the third time in the past three seasons against the Panthers and faces a Dolphins secondary that’s made Phillip Rivers and Josh McCown look good and have allowed the fifth-most net passing yards this season.
Jordy Nelson faces a Bears defense Thursday that has allowed opposing top receivers Julio Jones, Mike Evans and Antonio Brown to average seven catches and 89.7 yards while scoring twice.
Dalvin Cook amassed 32 touches in Week 3 while scoring his first career touchdown, and that volume helps dispel any concern when facing a 12th ranked Lions rush defense that has allowed only 86 yards per game.
Greg Zuerlein has been kept surprisingly busy by the much-improved Rams offense, so expect him to get a few looks Sunday in Dallas' kicker-friendly dome environment.
Joe Mixon rushed 18 times for 62 yards and caught three passes for 39 more yards last Sunday against the Green Bay Packers, dominating the touches among Cincinnati Bengals running backs and seemingly taking the lead in what had previously been a running back committee just in time for a match-up against a Cleveland Browns defense that gave up 92 yards and three touchdowns on the ground to the Indianapolis Colts in Week 3.
Larry Fitzgerald's volume gives him a high floor Sunday against the 49ers regardless of Arizona's game plan.
With tight ends struggling around the league, Cameron Brate seems like an appealing option against a Giants defense that allowed eight receptions, 55 yards and a touchdown to Zach Ertz last week.
Eli Manning will have a Week 4 tilt against the Buccaneers, who have allowed 300-yard passing days to both Mike Glennon and Case Keenum to start the season.
Justin Tucker made his only extra point attempt and did not attempt a field goal last Sunday in a blowout loss to the Jacksonville Jaguars, but if he gets the opportunities he is still one of the best kicking threats this Sunday against the Pittsburgh Steelers.
Cody Parkey will have a Sunday matchup against the Saints, who have allowed opposing place kickers eight field-goal attempts over the first three games of the season.
Jake Elliott will take on the Chargers in Week 4, after having attempted exactly three field goals in each of the first three games to start the season.
Matthew Stafford has only three touchdown passes in his last two games and faces a Vikings defense that limited him to 225.5 yards in two meetings last season and three total scores.
Kenny Stills will have a Sunday tilt against the Saints after having seen 15 targets over the first two games of the season.
Pierre Garcon continues to be the lone San Francisco receiver worth owning heading into a Week 4 date with cornerback Patrick Peterson and the Cardinals.
Kai Forbath has topped double-digit points in two of three outings despite missing two of his 14 attempts entering a matchup against the Lions' 13th ranked scoring defense which allows 21 points per game.
Jeremy Mclin caught only one of five targets for eight yards, in a blowout loss in which his starting quarterback only threw for 28 yards, so he will look to bounce back to his usual levels this Sunday in a big match-up against the Pittsburgh Steelers.
Javorius Allen carried eight times for 15 yards and caught five passes for 13 more last Sunday in a blowout loss to the Jaguars, and his 13 touches vs nine from Alex Collins and six from Terrance West indicate that he is perhaps the leader of a 3-way running back committee moving into his Week 4 match-up against the Steelers.
Jared Goff has the confidence and weapons to find success Sunday in Dallas despite the run-first approach employed by his team.
Carson Wentz will have a Week 4 matchup against the Chargers, who have yet to allow more than 230 passing yards to any quarterback they’ve faced.
Rob Gronkowski will have a Sunday matchup with the Panthers, who haven’t allowed an opposing tight end to post more than 27 yards in a game this season.
Cam Newton threw for no touchdowns and three interceptions against a Saints defense that allowed 447 passing yards the previous week, but faces another sub-par secondary on Sunday in the Patriots, who let DeShaun Watson to break the 300-yard barrier last week.
Jacquizz Rodgers has just one week left as the clear-cut starter and, after just five carries last week, faces a Giants defense that allowed 193 yards to the Eagles stable of far-from-heralded backs.
LeGarrette Blount will have a Sunday tilt against the Chargers, who have allowed at least 122 rushing yards to each of the last to lead running backs they faced.
Paul Richardson will be looking to stretch his touchdown streak to three consecutive games Sunday against Indianapolis' 29th-ranked pass defense.
Julius Thomas will have a Week 4 tilt against the Saints, who have allowed two tight ends to score against them in the first two games of the season.
Davante Adams has only three catches in two of the first three games this season and garnered more defensive attention last week with Randall Cobb (chest) sidelined, seemingly making him a touchdown-dependent play Thursday against Chicago.
Andy Dalton completed 21 of 27 passes for 212 yards and two touchdowns last Sunday against the Green Bay Packers, by far his best game of the season thus far, which gives him some positive momentum going into Sunday's game against the Cleveland Browns.
Charles Clay will take on the Falcons in Week 4 after scoring two touchdowns over the first three games of the season.
Willie Snead returns from a three-game suspension to face the Dolphins' bottom-five secondary in net passing yards allowed.