LeSean McCoy scored twice when the Buffalo Bills faced the Miami Dolphins just two weeks ago, and the Bills have plenty left to play for with a possible playoff berth in their sights.
Kenyan Drake was held under 100 yards from scrimmage for the first time in four games this past Sunday, but will face a Buffalo Bills defense that's allowed 126.7 rushing yards per contest in 2017, which is 30th in the NFL.
Carlos Hyde scored two touchdowns against the Rams back in Week 6, so he'll be looking to close out his season on a high note against Los Angeles' 24th-ranked run defense Sunday.
Alex Collins has double-digit carries in 11-straight games, as he faces a Cincinnati Bengals defense this week who allow the second-most fantasy points to opposing RB's.
Mark Ingram's role around the goal line and his continued involvement in the passing game, even as Alvin Kamara continues to impress, gives him top-end value in Week 17 against the Bucs' second-worst total defense that has allowed 381.7 yards per game.
Christian McCaffery had one of his worst receiving games of the season last week with just two receptions, yet there are signs of hope for McCaffery shareholders as he set a career-high in rushing yards against the Falcons earlier this season and has 75 receptions on the season, making him a potential upside option in Week 17.
Dion Lewis saw an expanded role due to the injury to Rex Burkhead this past weekend, and is in line for a heavy workload once again versus a New York Jets defense allowing 116 rushing yards per game in 2017, which is 19th in the NFL.
Alvin Kamara caught seven passes last week and has 75 receptions on the season, which makes him an excellent option in Week 17 against the Bucs' league-worst pass defense.
C.J. Anderson has piled up 361 rushing yards over the last four games, and he'll look to cap off his first career 1000-yard season in Sunday's home tilt against a Chiefs defense allowing 118.7 rushing yards per game, 23rd in the league.
Marshawn Lynch topped 90 yards from scrimmage for the fourth time in the last five games in Week 16, and he should finish the season on a high note Sunday on the road against a Chargers defense that's surrendered a league-worst 132.9 rushing yards a game.
Kareem Hunt has found the end zone in three straight games while amassing 450 yards from scrimmage, and if he doesn't take a seat early in a meaningless game for the Chiefs he could be looking for redemption Sunday on the road against a Broncos defense that held him to 68 total yards in Week 8.
Frank Gore is expected to play his final game in a Colt uniform Week 17 against the Houston Texans, who rank 32nd in offensive touchdowns allowed (42).
With Devonta Freeman struggling around the goal line, Tevin Coleman could be in line for an expanded role in the red zone as well as in the passing game, even against the Panthers' sixth-best run defense in Week 17.
Lamar Miller was joined by Alfred Blue to give the Houston Texans their most productive rushing output of the season last week and repeat performance could occur Week 17 against the Indianapolis Colts, who rank 28th rushing touchdowns allowed (14).
Jamaal Williams has been limited to 25 carries and 88 yards over the last two weeks, but figures to be the focal point of the offense Sunday against a Lions' rush defense that allows 113.1 yards per game and 4.2 yards per carry.
Bilal Powell has three touchdowns in the last four games and rushed for 145 yards in his last contest, but will face a New England Patriots defense that's allowed just six rushing scores in 2017, which is tied for second in the league.
Javorius Allen has 37 or less rushing yards in six of his last seven games, but faces a Cincinnati Bengals defense this week who allow the second-most fantasy points to opposing running backs.
Leonard Fournette, who has dealt with ankle and quadriceps injuries, is an obvious candidate to be rested Week 17 as the Jacksonville Jaguars are locked in as the third seed in the AFC ahead of their Week 17 matchup against the Tennessee Titans.
Samaje Perine will have a Week 17 tilt against the Giants, who have allowed almost 4.5 yards per carry to running backs over the last six weeks.
Jay Ajayi will face the Cowboys in Week 17, but with him splitting backfield carries against a strong run defense with linebacker Sean Lee on the field, he’ll likely need a big play or two to post a strong fantasy performance.
Malcolm Brown is expected to serve as the lead back for Sunday's finale against the 49ers with Todd Gurley (rest) not suiting up.
Ezekiel Elliott will be up against the Eagles on Sunday, and although the Eagles have been a top-10 unit against RBs since mid-November, don’t expect the Cowboys to shy away from calling his number often, giving him solid upside.
Kapri Bibbs will continue to see touches behind Samaje Perine against a Giants defense that’s been in the bottom quarter of the league in terms of fantasy points allowed to running backs over the last six weeks.
Peyton Barber appears to have established himself as the featured back and should see plenty of opportunities in Week 17 against the Saints' 16th-best run defense.
Latavius Murray has 20 or more carries in two straight and three of his last five entering Sunday's matchup against a ninth-ranked Bears run defense that allows 105.5 yards per game but no touchdowns to a running back since Week 10.
Melvin Gordon found the end zone for the third straight game last week, but an ankle injury given him additional risk Sunday in a must-win game for the Chargers at home against a Raiders defense allowing 108.5 rushing yards a game, 13th in the league.
Le'Veon Bell is just 151 total yards away from reaching 2,000 for the season, as he faces a Cleveland Browns defense this week who are allowing a league-best 3.3 yards per carry.
After DeMarco Murray suffered a significant knee injury Week 16, Derrick Henry is expected to be the feature back for the Tennessee Titans in Week 17 against the Jacksonville Jaguars, who rank eighth in rushing touchdowns allowed (nine).
Giovani Bernard collected a season-high 168 total yards in relief of Joe Mixon (ankle/concussion) last week, as he faces a Baltimore ravens defense this week who allow the 11th-most fantasy points to opposing RB's.
Danny Woodhead has yet to record more than 45 total yards in any game this season, but faces a Cincinnati Bengals defense this week who allow the second-most fantasy points to opposing RB's.
Tion Green has earned carries over Ameer Abdullah,and could see further increased chances with Theo Riddick still dealing with a wrist injury in Sunday's game against the Packers' 20th-ranked run defense that allows 116.1 yards per game.
Jonathan Stewart ran just seven times last week, and in the absence of finding the end zone, may struggle for opportunities in Week 17 against the Falcons' ninth-best run defense that's allowed the eighth-fewest rushing touchdowns this season.
Charcandrick West has seen only eight touches over the past three games, but his workload could increase in Sunday's road game against the Broncos if Kareem Hunt is pulled early to try and prevent him from getting hurt ahead of the playoffs.
Joe Mixon has been dealing with a concussion and knee issues the least three games, as he's averaging just 3.3 yards per carry for the season.
Matt Breida remains Carlos Hyde's backup, but don't be surprised to see the rookie free agent get a decent workload in Sunday's finale against the 24th-ranked Rams run defense.
Branden Oliver saw eight carries last week, although he turned them into only nine yards, and with Melvin Gordon nursing an ankle injury he could see a surprising workload Sunday at home against a Raiders defense allowing 108.5 rushing yards a game, 13th in the league.
If the Houston Texans continue to lean toward the rushing attack, then Alfred Blue will be in a position to help fantasy owners Week 17 against the Indianapolis Colts' 27th-ranked defense against the rush (122.8 YPG).
Mike Gillislee has returned to his role as the goal line back for the New England Patriots with the injury to Rex Burkhead, and will face a New York Jets defense that's allowed 12 rushing touchdowns in 2017, which is tied for 16th in the league.
Devonta Freeman fumbled for the fourth time in the last three games and gets a difficult matchup in Week 17 against the Panthers' sixth-best run defense, which makes him tough to trust in Sunday's must-win game.
Kerwynn Williams is Arizona's lead back, but that's about all he's got going for him heading into Sunday's road tilt against Seattle's middling run defense.
Jerick McKinnon has nine or fewer carries in four straight games and has been held two one catch in two of his last three entering Sunday's matchup against the Bears' ninth-ranked rush defense that allows 105.5 yards per game.
Theo Riddick has led the team in carries in two of the last three weeks, but could see fewer touches Sunday against the Packers' 20th-ranked run defense that allows 116.1 yards per game if his wrist injury continues to linger.
If the Jacksonville Jaguars choose to limit starter Leonard Fournette Week 17, Ivory could be in line for double-digit touches against the Tennessee Titans' fifth-ranked rushing defense (89.1 YPG).
Jordan Howard has four touchdowns in his last three games, but has averaged 3.7 yards or fewer in four of his last five entering a Sunday matchup against a second-ranked Vikings rush defense that allows 87.1 yards per game.
Corey Clement will be up against the Cowboys on Sunday, but as he’s been seeing roughly six touches per game over the last month or so, his upside will be limited unless he somehow sees an increase in work.
T.J. Yeldon's playing time has ticked up over the past two games and he could get significant touches if the Jacksonville Jaguars rest starter Leonard Fournette in Week 17 against the Tennessee Titans, who rank 14th in offensive touchdowns allowed (32).
Orleans Darkwa will have a Sunday matchup against the Redskins, who once were a great matchup against the run, but have improved into an above-average unit over the last six weeks.
LeGarrette Blount will have a Sunday tilt against the Cowboys, but now that he’s been seeing fewer touches than Jay Ajayi, he’s on the short end of a running back by committee that limits his upside.
Marlon Mack will be the Indianapolis Colts' second back behind Frank Gore in Week 17 against the Houston Texans, who have allowed a league-most 42 offensive touchdowns in 2017.
Rod Smith will be up against the Eagles in Week 17, but he won’t likely see more than a handful of touches while Ezekiel Elliott takes the majority of running back touches.