Rashard Higgins has six catches for 113 yards over his past two outings for the Browns, and in Week 12, he gets a Jaguars defense allowing 185.5 yards per game to his position, the sixth-highest total in the league.
Baker Mayfield hasn't thrown for a touchdown in any of his past three games for the Browns, but in Week 12, he gets a Jaguars defense that has allowed 21 scores through the air, just two shy of the most in the league.
Cody Parkey has missed just two of his 41 kicks this season for the Browns, and in Week 12, he gets a Jaguars defense allowing 29.8 points per game, the third-highest total in the league.
KhaDarel Hodge caught three passes for the first time all season for the Browns his last time out, and in Week 12, he gets a Jaguars defense allowing 185.5 yards per game to his position, the sixth-highest total in the league.
Dalvin Cook has seen at least 24 touches in four straight games and has 13 rushing scores through nine outings, and should again be busy and successful for the Vikings in Week 12 against a Panthers defense allowing 4.6 yards per carry and 14 rushing scores to date.
Duke Johnson should see the majority of Houston's backfield touches for a fourth consecutive game with David Johnson (concussion) sidelined, and a Week 12 date with a Lions defense that has allowed league highs in both rushing touchdowns (14) and receiving touchdowns (five) to running backs should help get the struggling Texans tailback back on track.
Jarvis Landry has not gained 30 yards over either of his past two outings for the Browns, but in Week 12, he gets a Jaguars defense allowing 185.5 yards per game to his position, the sixth-highest total in the league.
Tyreek Hill has posted back-to-back 100-yard performances and has scored in every game but one this season, and the Kansas City speedster figures to be dangerous again in Week 12 against a Buccaneers defense that had trouble containing Cooper Kupp and Robert Woods on Monday night.
Justin Jefferson continues to make big plays for the Vikings, averaging at least 16.9 yards per catch in each of his past three games, and could see a huge uptick in targets in Week 12 against a decent Panthers pass defense that's allowing 6.9 yards per attempt if Adam Thielen (Covid) is forced to sit.
Dustin Hopkins has booted at least two field goals in four of the last five games for Washington and will face a putrid Dallas defense in Week 12 that's allowed the most points in the NFL this season.
Ryan Finley is set to take over under center in Week 12 for the Bengals where he'll get a Giants defense allowing 275.2 receiving yards per game, the seventh-highest total in the league.
Antonio Gibson has scored in four-straight games for Washington and will face a lackluster Cowboys run defense in Week 12 yielding 153.8 yards per contest on the ground, which is 31st in the NFL.
Jason Sanders knocked through both of his field goal attempts including a 53-yarder heading into a matchup with the Jets in Week 12, who have allowed 30 points per game this season.
Dawson Knox saw four targets but couldn't really make much out of it heading into the Bills bye week prior to their Week 12 matchup with the Chargers, who have allowed eight touchdowns to opposing tight ends this season including TDs in four-consecutive games.
Terry McLaurin is fourth in the NFL in receiving yardage for the Washington Football Team and will face a suspect Dallas pass defense in Week 12 allowing 232.6 passing yards per contest, which is 14th in the league.
Deshaun Watson has thrown for 300-plus yards in five of his last seven games, and given his lack of support from the defense and running game, Houston's star quarterback will likely shoulder a heavy Week 12 load against a Lions defense that's allowing 28.7 points per game.
Mike Gesicki did an excellent job working as a strong second option in the Dolphins passing game heading into Week 12 against the Jets, who have allowed five touchdowns to opposing tight ends in the last five games.
Patrick Mahomes has thrown for more than 340 yards in three straight games with an 11:1 TD:INT, and the Kansas City superstar may not slow down in Week 12 against a Buccaneers defense that just got lit up by Jared Goff on Monday night.
David Montgomery (concussion) appears to be trending towards a Week 12 return for the Bears, and while he's been plodding for the majority of the year, volume has always been steady and should continue against Green Bay, both because Chicago has questions under center and because the Packers are allowing 4.4 yards per carry, and four opposing rushers have gone for 90+ yards against them in the last six weeks.
Alvin Kamara and the Saints have a solid Week 12 matchup against a Broncos defense that has allowed the sixth-most fantasy points to running backs per game (21.6) since Week 6.
Davante Adams has scored in five straight, catching at least seven balls in each game during that stretch, and that steady volume should allow him to lead the Packers again in Week 12 against a Bears defense that's allowed only five touchdown catches to opposing receivers, but three in the last two weeks, with two receivers topping 100 yards in that stretch.
Jakeem Grant saw six targets, tied for second-most on the Dolphins, but mustered just 12 yards heading into a much better matchup in Week 12 against the Jets and their bottom-five secondary.
Tyler Eifert has just one touchdown this season and is yet to break 50 yards in a Jaguars uniform, but perhaps he can turn things around in Week 12 against a Browns defense that has allowed the fifth-most yards (583) and fourth-most touchdowns (seven) to tight ends.
Derek Carr threw three touchdowns last week for the third time this season, and the Raiders quarterback figures to air it out frequently in Week 12 on the road against a Falcons defense that ranks second-last in the league in passing yards per game allowed and passing TDs allowed.
Robert Woods has scored a TD in four of the Rams' last six games, and he'll have a favorable Week 12 matchup against a 49ers defense that's allowed the 12th-most fantasy points to WRs.
Brandin Cooks has 496 receiving yards in his last six games, and he should continue to play a prominent role in Houston's passing attack in Week 12 against a Lions secondary that has allowed the fifth-most yards to wide receivers this season (1,855).
Travis Kelce is coming off his fourth 100-yard performance of the season, and he figures to get plenty of volume in Week 12 as Kansas City faces a Buccaneers defense that's tied for 25th in the league in receptions allowed to tight ends.
Keenan Allen posted a season-high 16 catches for 145 yards last week, and his typically sky-high target volume gives him a very high floor heading into the Chargers' Week 12 road clash with a Bills defense that ranks 17th in passing yards per game allowed.
Ka'imi Fairbairn has been automatic from inside 40 yards and has made 16 of 19 field-goal attempts overall this season heading into Houston's Week 12 matchup with a Lions team that's allowing 28.7 points per game.
Wil Lutz and the Saints have a solid Week 12 matchup against a Broncos defense allowing the sixth-most points per game (28.2) in 2020.
Jalen Reagor has amassed eight catches for 99 yards over his last two contests for Philadelphia and has the chance for a breakout performance in Week 12 versus a lackluster Seattle secondary allowing the most passing yards per game in the NFL this season.
Michael Pittman is starting to come into his own with 167 receiving yards a touchdown over the past two weeks, and the Colts' rookie second-round pick will look to build on his recent momentum in Week 12 against a Titans defense that's allowing 267.4 passing yards per game.
Justin Herbert has thrown multiple touchdowns in a remarkable seven straight games, posting a 20:4 TD:INT over that stretch, and the Chargers rookie figures to extend that streak in Week 12 against a Bills defense that ranks 22nd in QB rating against.
Younghoe Koo and the Falcons have a solid Week 12 matchup against a Raiders defense allowing the 12th-most points per game (26.8) in 2020.
Kerryon Johnson played 70 percent of the snaps for the Lions last week in D'Andre Swift's absence, and while that turned into only eight touches, he looks like the preferred option for the Lions in Week 12 on Thursday should Swift sit again, and facing a Texans defense that allows 5.1 yards per carry, he may not need many touches to produce.
Darren Waller caught his fourth touchdown of the season last week, and Derek Carr's favorite target could be headed for a huge performance in Week 12 as the Raiders face a Falcons defense that ranks in the bottom four in catches, yards and TDs allowed to tight ends.
Stefon Diggs narrowly missed out on his fifth 100-yard game of the season for the Bills just prior to the bye week and is in line to break the 1,000-yard marker for the season heading into Week 12 against the Chargers, who showed some cracks in their coverage over the top last week against the Jets.
Joey Slye and the Panthers have a decent Week 12 matchup against a Vikings defense allowing the 10th-most points per game (27.4) in 2020.
Philip Rivers has a trio of three-touchdown performances in his last five games heading into a Week 12 matchup with a Titans defense that the veteran Colts quarterback carved up for over 300 yards two weeks ago.
Carson Wentz has as many interceptions as touchdowns thrown in 2020 for the Eagles, but should still start Week 12's clash with the Seattle Seahawks, whose defense is allowing a league-worst 343.7 passing yards per contest.
Will Fuller already has a career-high 708 receiving yards, as he and Brandin Cooks are the clear-cut top two receiving options for the Texans heading into a Week 12 matchup with a Lions defense that has allowed 1,855 yards to wide receivers -- fifth-most in the league.
Rodrigo Blankenship is coming off his third performance of four-plus made field goals for the Colts, and he's 23-for-26 overall heading into a Week 12 date with a Titans team that's allowing 25.9 points per game.
DeVante Parker hauled in a fantastic touchdown grab as he's shown himself to be a dependable performer week-in, week-out for the Dolphins heading into a matchup with the Jets, who boast one of the worst and youngest secondaries in the NFL.
Latavius Murray and the Saints have a solid Week 12 matchup against a Broncos defense that has allowed the sixth-most fantasy points to running backs per game (21.6) since Week 6.
Austin Hooper has just four catches for 44 total yards over his past two outings for the Browns, but in Week 12, he gets a Jaguars defense allowing 55.7 yards per game to tight ends, the seventh-highest total in the league.
Daniel Carlson hasn't scored fewer than seven points in any game this season, and he figures to extend that streak in Week 12 as the Raiders face a Falcons team allowing 27.5 points per game, 25th in the league.
Josh Allen showed a few issues with protecting the ball for the Bills prior to the bye week, but he'll get an opportunity to get back on track against a Chargers defense in Week 12 that's allowed 17 passing touchdowns in their last seven games.
Cooper Kupp has posted at least 40 yards in all but one of the Rams' games this season, and he'll have potential for upside in a Week 12 matchup against a 49ers defense that's allowed the 12th-most fantasy points to WRs.
Adrian Peterson saw only seven carries in D'Andre Swift's absence last week, his fourth straight game with eight carries or less, suggesting he won't see enough touches for the Lions in Week 12 on Thursday to take advantage of a soft Texans run defense that allows 5.1 yards per carry.
Dallas Goedert led the Eagles in receiving last game while also finding the end zone, though the possible return of Zach Ertz to the lineup could stunt his progress, even in Week 12 versus a Seattle defense allowing a staggering 343.7 passing yards per outing.