Ryan Tannehill's coming off a clunker but has a chance to secure the AFC South crown for the Titans in Week 17 if he can beat a Texans team that's allowing 28.2 points per game -- seventh-most in the league.
After tossing 356 yards and three scores to a Julio Jones-less receiving corps against Tampa Bay in Week 15, Matt Ryan and the Falcons - possibly without Jones again - will match up with a Buccaneers defense in Week 17 that has allowed the third-most passing touchdowns (18) since Week 8.
While he will again be without star receiver Michael Thomas, Drew Brees and the Saints have a welcoming Week 17 matchup against a Panthers defense that has allowed the seventh-most yards per pass attempt (7.4) and the eighth-most passing touchdowns (16) since Week 8.
Philip Rivers will be highly motivated in Week 17 against a Jaguars defense that has allowed 33 passing touchdowns this season, as the Colts need a win and some help to get into the playoffs.
Ben Roethlisberger has thrown for multiple scores in three of his past four outings for the Steelers, and in Week 17, he gets a Browns defense that has allowed 28 passing touchdowns this season, tied for ninth-most in the league.
Deshaun Watson intends to play through an arm injury in Houston's Week 17 season finale, and he'll be looking for his 10th 300-yard passing performance in his last 13 games against a Titans defense that has allowed over 40 points twice in its last four games.
Aaron Rodgers has three or more touchdown passes in five of six and eight of 10 for the Packers entering a Week 17 contest against a Bears defense he lit up for four scores previously, and one that's allowed at least two TD passes in seven of their last eight.
Kirk Cousins has multiple touchdowns in seven of nine games and a 21:3 TD:INT ration since the team's Week 7 bye entering a meaningless Week 17 contest against a Lions defense that's allowing 8.4 ypa and 35 touchdown passes to date, with his upside only being limited by how equally vulnerable the Lions are to opposing rushing attacks.
Lamar Jackson has passed for multiple touchdowns in three of his past four games for the Ravens, and in Week 17, he gets a Bengals defense that has allowed 29 scores through the air this season, seventh-most in the NFL.
Jared Goff played through a broken thumb he suffered in the Rams' last game, and after undergoing surgery, he's been ruled out against the Cardinals in Week 17.
Justin Herbert set a new NFL record for passing touchdowns by a rookie last week, and he'll take aim at the completions and passing yards records in Week 17 as the Chargers face a Kansas City team that ranks fifth in QB rating against, but which is likely to be resting key players.
Tom Brady and the Buccaneers have a middling Week 17 matchup with a Falcons defense that ranks ninth in passing touchdowns allowed (eight) and 16th in yards allowed per pass attempt (7.0) since Week 8.
Josh Allen threw for another four touchdowns and will look to cap his regular season off on a high note with a visit from Miami in Week 17, who are in the top-10 against the pass this season and have allowed more than two passing touchdowns just twice this season--one of which was to Allen in Week 2.
Mitchell Trubisky has provided the Bears with at least 265 yards and three touchdowns in three of his last five outings, and will need every bit of that if Chicago is to keep pace and win to get into the playoffs in a Week 17 matchup with a Packers secondary that's allowed just three touchdown passes in the last four weeks.
Alex Smith sat out last game for Washington due to a calf injury, and it is not guaranteed that he suits up in Week 17 versus the Eagles; however, if he does, he will have an extremely favorable matchup against a reeling Eagles pass defense that's given up an average of 391.5 passing yards over the last two contests.
Teddy Bridgewater and the Panthers have a tricky Week 17 matchup against a Saints defense that has allowed the seventh-fewest yards per pass attempt (6.8) but the 10th-most passing touchdowns (28) in 2020.
Derek Carr topped 300 passing yards last week for the fifth time this season, but he could struggle to reach that mark in Week 17 as the Raiders face a Broncos defense allowing 229.9 passing yards a game, 12th in the league.
Mike Glennon has compiled a 5:5 TD:INT in four starts under center for Jacksonville this season, but it remains to be seen whether he gets the nod for the Week 17 finale against a Colts team that's allowing just 23.2 points per game and needs a win to keep its playoff hopes alive.
Kyler Murray (leg) has accounted for one or fewer touchdowns in three of the Cardinals' last five games, but he'll have a Week 17 matchup against a Rams defense that he threw three touchdown pass against in Week 13.
Gardner Minshew backed up Mike Glennon last week, but coach Doug Marrone reportedly considered turning to Minshew under center after Jacksonville fell behind in that one and may call on the mustachioed signal-caller to start the Week 17 finale in Indianapolis.
Jarett Stidham couldn't get into any rhythm in relief of Cam Newton for the Patriots, but could be in line for the start in Week 17 against the Jets' bottom-five secondary.
Drew Lock threw two more interceptions last week, but the Broncos' quarterback will look to end his season on a high note in Week 17 against a Raiders defense allowing 259.2 passing yards a game, 25th in the league.
Taylor Heinicke looked competent last game for Washington, completing 12-of-19 passes for 137 yards and a touchdown in relief, and would start in Week 17 if Alex Smith can't go against a suspect Eagles secondary that's given up an average of 391.5 passing yards over the last two contests.
Daniel Jones appears to have lost his ability to run effectively due to nagging injury, but the Giants will face a suspect Dallas pass defense in Week 17 that's allowed 32 passing touchdowns in 2020, which is 29th in the NFL.
Sam Darnold did an excellent job managing the game for the Jets and may be playing for his future in Week 17 against the Patriots top-10 pass defense that struggled this past Monday night.
Jalen Hurts has amassed over 400 scrimmage yards in each of the last two games for the Eagles, but will face a stout Washington defense in Week 17 allowing just 310.5 yards from scrimmage per contest in 2020, which is fourth in the NFL.
Tua Tagovailoa was benched in the fourth quarter for the Dolphins after a rocky performance last week, but has been assured that he'll be the starter for the Week 17 clash with the Bills, who have been much stingier against the pass of late, allowing less than 200 passing yards in their previous two games.
C.J. Beathard threw three touchdown passes in the 49ers' last game, but he'll have a tough Week 17 matchup against the Seattle defense that's allowed just two touchdown passes over their last four games.
Matthew Stafford will need to overcome a new ankle injury, in addition to lingering rib and thumb issues if he's to face a Vikings defense in Week 17 that's allowed multiple touchdown passes just twice in their last eight games as teams continue to gash them on the ground.
Russell Wilson has thrown exactly one touchdown pass in four of Seattle's last five games, but he'll have a Week 17 matchup against a 49ers defense that he threw four touchdown passes against when facing them in Week 8.
Chad Henne could get the start in Week 17 with Kansas City having clinched the No. 1 seed in the AFC and looking to rest key players, but he may find little success against a Chargers defense allowing 224.1 passing yards a game, ninth in the league.
Cam Newton ran for a touchdown, but his inability to successfully run the Patriots' passing game led to Jarett Stidham coming in for the final third of the game and could put Newton on the bench for Week 17 against the Jets and their bottom-five secondary that's tightened up of late.
David Blough could be in line to start the Lions Week 17 matchup against the Vikings with Matthew Stafford (ankle/ribs/thumb) and Chase Daniel (ineffective) uncertain to get the nod, giving him a back end chance at production against a secondary that's allowed 27 touchdown passes, but multiple scores just twice in their last eight outings.
AJ McCarron could be thrust into a starting role for Houston's Week 17 season finale against a Titans team that has allowed 33 passing touchdowns if Deshaun Watson's arm injury proves to be more serious than initially thought.
Chase Daniel would compete with David Blough to start in Week 17 if the Lions choose to shut down Matthew Stafford (ankle/ribs/thumb), giving him a chance to go after a Vikings secondary that's allowed multiple touchdown passes just twice in their last eight outings as teams target their porous run defense.
Last week, Brandon Allen threw for multiple touchdowns for the first time in his four games this season for the Bengals, but in Week 17, he gets a Ravens defense that has allowed just 21 passing scores all season, tied for fifth-fewest in the league.
Ryan Fitzpatrick led the Dolphins to victory last week after coming in for Tua Tagovailoa during the fourth quarter, but will once again start on the bench in Week 17 for the Bills despite appearing to be the better quarterback.
Patrick Mahomes is expected to sit for some or all of Week 17's game against the Chargers with Kansas City having clinched the No. 1 seed in the AFC, potentially denying him an opportunity to reach 5,000 passing yards and 40 TDs on the season.
Baker Mayfield had thrown for at least 250 yards and multiple scores in his last four outings for the Browns prior to losing all of his starting receivers to the reserve/COVID-19 list last time out, but in Week 17, he gets a Steelers defense that has allowed just 21 touchdowns through the air this season, tied for the fifth-fewest in the league.