Mark Andrews has at least five catches and 61 yards in each of his past five outings for the Ravens, and in Week 17, he gets a Bengals defense that has allowed 64 yards per game to tight ends this season, the second-highest total in the league.
George Kittle returned to the 49ers' lineup last week after a six-week absence and posted 92 yards, and he'll have a Week 17 matchup against a Seattle defense that's allowed the sixth-most fantasy points to opposing tight ends over the last five weeks.
New Orleans' Jared Cook has a great Week 17 matchup against a Panthers defense that has allowed the fourth-most yards per target to tight ends (8.7) and the third-highest completion rate to tight ends (75.4) since Week 8.
Logan Thomas has a staggering 28 targets over the last two contests for Washington, and has a delectable matchup in Week 17 versus a reeling Eagles pass defense that's given up an average of 391.5 passing yards over the last two tilts.
Hayden Hurst and the Falcons have a solid Week 17 matchup against a Buccaneers defense that has allowed the third-most passing touchdowns (18) and the highest completion rate to tight ends (78.8) since Week 8.
Jack Doyle has topped 40 yards twice in his last three games, and he has a tenuous hold on the Colts' top tight end spot heading into the team's must-win Week 17 matchup with a Jaguars team that has allowed 13 touchdowns to tight ends -- tied for most in the league.
Robert Tonyan saw a five-game scoring streak snapped last Sunday for the Packers and hasn't topped 39 yards in four straight, making him a touchdown dependent option in Week 17 against a Bears defense that's been incredibly vulnerable to tight ends to date, allowing 10 touchdown catches, and one Tonyan went for 5-67-1 against earlier in the year.
Darren Waller has erupted for a 34-537-3 line on 45 targets over the last four games, giving him massive momentum heading into the Raiders' Week 17 clash with a Broncos defense that ranks 22nd in receiving yards allowed to tight ends.
Eric Ebron has at least five targets in all but three outings this year for the Steelers, and in Week 17, he gets a Browns defense that has allowed nine touchdowns this season to tight ends, tied for the sixth-most in the league.
Dawson Knox had another strong game for the Bills and faces a Dolphins defense in Week 17 that's allowed more than 100 yards to opposing tight ends in two of the last three weeks--in no small part to facing Travis Kelce and Darren Waller.
Rob Gronkowski and the Buccaneers have a middling Week 17 matchup with a Falcons defense that ranks ninth in passing touchdowns allowed (eight) and 16th in yards allowed per pass attempt (7.0) since Week 8.
Irv Smith has scored three times in as many weeks, and assuming Kyle Rudolph (foot) misses his fourth straight game Sunday in Week 17, Smith will face a reeling Lions defense that's allowed four touchdown receptions to opposing tight ends in as many weeks, and one which Smith scored twice against previously this season.
Noah Fant has posted an 18-190-1 line on 27 targets over his last three healthy games, and he could see high volume again in Week 17 as the Broncos host a Raiders defense that's only allowed five TDs to tight ends this season, tied for eighth in the league.
Dan Arnold has been targeted five times in each of Arizona's last two games, and he'll have a Week 17 matchup against a Rams defense that he posted 61 yards and two touchdowns against when facing them in Week 13.
Tyler Higbee has posted at least 34 yards in each of the Rams' last three games, and he'll have a Week 17 matchup against an Arizona defense that he posted 24 yards and a touchdown against when facing them in Week 13.
Trey Burton has been outplayed by fellow Colts tight end Jack Doyle recently, so he'll be a touchdown-dependent Week 17 option against a Jaguars defense that has allowed 13 touchdowns to the position, which is tied with the Jets for most in the league.
Mike Gesicki led the Dolphins in targets with seven and will be a crucial piece of their passing game in Week 17 against the Bills, who are in the bottom 10 against opposing tight ends this season.
Jordan Akins' nine catches in the last two games are tied for the most Houston's starting tight end has posted in a two-game stretch this season, and he'll look to stay involved in Week 17 against a Titans defense that has hovered around league average at defending tight ends.
Devin Asiasi couldn't haul in either of his two targets as the Patriots' passing game hasn't clicked heading into Week 17 against the Jets, who are worst in the league against opposing tight ends.
Jonnu Smith secured his eighth receiving touchdown of the season last week, and Tennessee's top tight end will look to add to that career-high total in Week 17 against a Texans defense that has allowed six touchdowns to tight ends this season.
Ian Thomas and the Panthers have a tricky Week 17 matchup against a Saints defense that has allowed the seventh-fewest yards per pass attempt (6.8) but the 10th-most passing touchdowns (28) in 2020.
Kyle Rudolph hasn't played in the Vikings last three games due to a foot injury, and with the team eliminated from playoff contention, there's little reason for him to suit up in a Week 17 finale against a Lions defense that's allowed four tight end scoring receptions in as many weeks.
Zach Ertz racked up six targets in the fourth quarter last game for the Eagles once Dallas Goedert left with a calf injury, and would be targeted heavily if Goedert is sidelined in Week 17, though opponent Washington is allowing the third-fewest passing yards in the NFL per game this season.
Travis Kelce set a new NFL record for receiving yards in a season by a tight end last week and is only 43 yards behind Stefon Diggs for the overall receiving yards title, but with Kansas City having already clinched the No. 1 seed in the AFC and likely to rest key players, he may not see much work in Week 17 against a Chargers defense that's given up 10 TDs to TEs this season, tied for 27th in the league.
Chris Herndon finished with four receptions including a touchdown on just his third red-zone target of the season for the Jets heading into Week 17 against the Patriots, who have been one of the top-five stingiest defenses against opposing tight ends this season.
Cole Kmet has at least six targets in three of the Bears last four games, but has managed just four catches and 30 total yards in his last two games, suggesting a low floor in Week 17 against a Packers defense that's allowed opposing tight ends to score in consecutive weeks, but only five to top 50 yards against them all season.
Hunter Henry missed last week's game while on the COVID-19 list, and there's no guarantee the Chargers' tight end will return for Week 17's clash with a Kansas City defense that ranks 26th in receiving yards allowed to TEs.
Durham Smythe caught a pair of short passes for the Dolphins as the return of Mike Gesicki tore into his playing time heading into a prime matchup against the Bills in Week 17, who are in the bottom 10 against opposing tight ends.
Gerald Everett has fallen a bit behind Rams teammate Tyler Higbee in the receiving tight end role over the last few weeks, making him a risky fantasy option in Week 17 against the Cardinals.
Evan Engram injured his ankle late last game for the Giants, leaving his status in question heading into a crucial Week 17 clash with a Dallas defense allowing 228.7 passing yards per tilt, which is 11th in the league.
T.J. Hockenson has just 41 yards over the last two weeks while scoring just once in the Lions last seven outings, and quarterback concerns in Week 17 against a Vikings defense that's allowed only five opposing tight ends to score against them to date lead to an ominous outlook to close the season.
Drew Sample has seen just one target in each of his last two outings for the Bengals, and in Week 17, he gets a Ravens defense that has allowed just five touchdowns to tight ends all season.
Jimmy Graham is coming off of a season-high 69 yards and has scored three times in as many weeks despite increased snaps for teammate Cole Kmet, but seems like a touchdown-dependent Week 17 option for the Bears against a Packers defense that's allowed the tight end to score in consecutive weeks, but just five at the position have topped 50 yards against them all year.
Greg Olsen was targeted twice in his return to the Seahawks' lineup last week, but he'll face a 49ers defense in Week 17 that shut him out on four targets back in Week 8.
Stephen Anderson made a surprising impact last week with Hunter Henry on the COVID-19 list, and he could see an increased role again in Week 17 as the Chargers face a Kansas City defense that ranks 26th in receiving yards allowed to TEs.
Jacob Hollister has found the end zone for the Seahawks in consecutive weeks, but he hasn't surpassed 20 yards in any of his last seven games, making him a risky fantasy option in Week 17 against a 49ers defense that's allowed the second-fewest fantasy points to opposing tight ends.
Austin Hooper has 12 catches on 21 targets over his past two outings for the Browns, but in Week 17, he gets a Steelers defense that has only allowed two touchdowns to tight ends this season.
Tyler Eifert has caught more than three passes in a game only twice this season, and Jacksonville's starting tight end will have his work cut out for him in Week 17 against a Colts defense that has allowed only three touchdowns to the position.
Dallas Goedert left Sunday's game for the Eagles due to a calf injury, leaving his status murky for a difficult Week 17 matchup with a Washington defense allowing just 198 passing yards per game, which is third in the NFL.
Dalton Schultz has been held under 50 yards receiving in seven-straight games for Dallas and will face a Giants defense in Week 17 surrendering 240.5 passing yards per tilt, which is 16th in the NFL.