Zach Ertz will have a Week 3 matchup against the Giants, wwho gave up 59 yards and a touchdown to Jason Witten in Week 1.
Austin Hooper crashed back down to earth last week (two receptions, seven yards), but faces a Lions defense in Week 3 that allowed Evan Engram to lead the Giants in all receiving categories last week.
Jimmy Graham's limited involvement in the passing game likely will change this week as the Seahawks make a determined effort to get the playmaking tight end the ball early and often, especially at the goal line.
Kyle Rudolph is coming off of a game where he reached the end zone and caught five passes on seven targets for the second straight week, and will face a Chargers defense that has allowed opposing tight ends to score in both weeks while also leading their respective teams in yards.
Tyler Eifert has led the Bengals in targets in each of the first two weeks, and his versatility and ability to create mismatches should mean that the passes continue to flow this week against a Baltimore Ravens defense that allowed 351 yards through the air against the Oakland Raiders in Week 2.
Jordan Reed will face the Raiders on Sunday, as he hopes to suit up after suffering a shoulder injury in last week's contest.
Delanie Walker was inactive last week due to a wrist injury and early in the week, his status is up in the air for Week 3 against the Indianapolis Colts.
Eric Ebron has a chance to bounce back from a low-usage Week 1 against a Giants defense that allowed seven catches and a touchdown to the Cowboys' Jason Witten last week.
Ben Watson erupted for eight receptions and 91 yards in Week 2, leading the team in both categories, and moves into a Week 3 match-up against the Jacksonville Jaguars as the top tight end on the Baltimore Ravens.
Jason Witten will have a Monday night matchup with the Cardinals who allowed eight receptions for 79 yards to Jack Doyle of the Colts in Week 2.
Vernon Davis has rejoined the San Francisco passing attack, catching eight passes for 109 yards on 13 targets through two games, and he'll now face an Arizona defense that struggled against opposing tight ends last season.
Zach Miller was second on the team in targets in Week 1, and could see more opportunities come his way following Kevin White's season-ending injury.
Travis Kelce remains one of Alex Smith's top options, but could see limited targets on Monday as the Chiefs try to attack a vulnerable Packers run defense that has allowed 5.3 yards per carry in 2015 rather than air it out.
Martellus Bennett garnered six targets in Week 1, catching one of the team's five passes of 20+ yards, giving him a puncher's chance at a big day Sunday night in a likely high-scoring contest at Atlanta.
Cameron Brate saw 17 red zone targets last season and is likely to continue to be a big threat inside the 20, even if O.J. Howard pilfers targets between the 20s.
David Njoku caught three passes for 27 yards and a touchdown as half of the Cleveland Browns tight end platoon, which makes him a risky play in Week 3 against the Indianapolis Colts.
O.J. Howard was targeted as often as Cameron Brate in the opener (three each) and could find himself a big target against the Vikings’ tough defense that allowed four receptions to Jesse James last week.
Gerald Everett picked up 95 yards last week, but will likely struggle Thursday against a 49ers defense that shut down Greg Olsen and Jimmy Graham.
Evan Engram will have a Week 3 tilt against the Eagles, who were torched by Travis Kelce last week for 103 yards and a touchdown.
Charles Clay found the end zone last week, and will have increased incentive this weekend as he faces his old team, the Miami Dolphins, who have allowed 372.5 yards per game this season.
Dwayne Allen could be a trendy sleeper pickup if Rob Gronkowski misses any length of time due to a groin issue.
Darren Fells didn't catch any passes in Week 2 against the Bears, and he'll now face a 49ers defense that should only further encourage quarterback Carson Palmer to hone in on his wide receivers.
Coby Fleener has six of his eight receptions and both touchdowns in the second halves of blowouts this season, but is still one of Drew Brees’ primary options in the passing game that throws early and often, and he'll look to stay productive in Week 3 against the Panthers.
Seth DeValve caught two passes for 61 yards as a piece of the Cleveland Browns' tight end committee, making him difficult to depend on in Week 3 against an Indianapolis Colts defense that allowed only two receptions for 63 yards to opposing tight ends in Week 2.
Julius Thomas caught three passes in the season opener but remains more of a safety valve than anything else in this offense behind Jarvis Landry, DeVante Parker and Kenny Stills.
George Kittle's seven catches through two weeks are good for third on the 49ers, but the team's offensive ineptitude should make the tight end a fantasy non-factor Thursday against the Rams.
Rob Gronkowski may not be able to suit up against the Houston Texans this weekend due to a groin injury which forced him from last weekend's game.
Richard Rodgers found the end zone in Week 2, but with only seven targets through three games, he remains heavily dependent upon scoring against the Chiefs to be starter-worthy.
Marcedes Lewis has been seriously under-utilized through two games and faces a similar fate Week 3 against the New England Patriots.
Nick Boyle fell behind Benjamin Watson on the tight end value chart, catching his only target for nine yards but trailing Watson by 82 yards, which makes him hard to rely upon against the Jaguars in Week 3.