Kirk Cousins will face the Giants in Week 17 in what should be a strong matchup against an injury-depleted defense that’s in the bottom-quarter of the league in fantasy points allowed to quarterbacks over the last six weeks.
Ben Roethlisberger has at least two touchdown passes in seven-straight games, as he faces a Cleveland Browns defense this week who allow the fifth-most fantasy points to opposing QB's.
Tom Brady and the New England Patriots are playing for home field advantage throughout the playoffs and will face a New York Jets defense that's allowed 28 passing scores in 2017, which is tied for 28th in the NFL.
Russell Wilson has been asked to do more than ever this season and should account for the vast majority of his team's offense in Sunday's must-win home game against Arizona's middling secondary.
Matt Ryan still doesn't have a game with more than two touchdowns this season, but broke the 300-yard barrier in Week 10 against the Panthers and will look to return to his 2016 form in a must-win matchup against Carolina on Sunday afternoon.
Nick Foles will have a Week 17 matchup against the Cowboys, who have been a bottom-eight defense against quarterbacks over the last six weeks, and he’ll be a solid starter as long as he plays the entire game.
With the Jacksonville Jaguars having clinched the third seed in the AFC, Blake Bortles could be limited or rested entirely Week 17 against the Tennessee Titans, who rank 24th in passing touchdowns allowed (27).
Matthew Stafford has one touchdown pass in three of his last four games and may not play all four quarters Sunday against the Packers 22nd ranked pass defense with both teams eliminated from playoff contention.
Marcus Mariota has been uneven in his performances this season, but the quarterback known for his resiliency and comebacks can pull out a postseason berth for the Tennessee Titans in Week 17 against the Jacksonville Jaguars, who rank fourth in passing touchdowns allowed (16).
Philip Rivers has thrown only five touchdowns over the last four games, but he should be more productive at home Sunday in a must-win game against a Raiders defense allowing a 99.3 QB rating on the season, 29th in the league.
Cam Newton, along with the rest of the Panthers offense, struggled last week against the Bucs, but with his fourth-straight game rushing for 50-plus yards, has a high floor in Week 17 against the Falcons.
Jacoby Brissett is coming off his best game in five weeks and heads into Week 17 against the Houston Texans, against whom he passed for 308 yards and two touchdowns in a Week 8 victory.
Tyrod Taylor failed to find the end zone last weekend but will face a Miami Dolphins defense on which he scored twice just two weeks ago in a 24-16 Buffalo victory.
Brett Hundley faces a 28th-ranked Lions pass defense on Sunday that has allowed at least 269 yards and a touchdown to four of the last five quarterbacks they've faced.
Drew Brees broke the 4,000-yard barrier last week, but could once again play more of a game manager in Week 17 against the moribund Bucs, even as they've allowed the most passing yards per game.
T.J. Yates overcame a six-sack week that briefly landed him in the concussion protocol, but should be able to go Week 17 against the Indianapolis Colts, who rank 19th in passing touchdowns allowed (23).
Jameis Winston had his best game as a passer against the Panthers last week, but his three lost fumbles put a blemish on what was otherwise an excellent day and will look to end his season on a high note in Sunday's matchup against the Saints' 11th-best pass defense.
Dak Prescott will have a Week 17 matchup against the Eagles, who after being one of the tougher matchups for quarterbacks in the first half of the season, have now fallen to being a middle of the pack unit over the last month.
Patrick Mahomes will make his first NFL start in Week 17, but he faces a stiff initial test on the road against a Broncos defense that's allowed the fourth fewest passing yards in the NFL this season.
Paxton Lynch will get one more chance in Week 17 to put himself in Denver's future plans, but he'll be a risky play Sunday in a home game against a Chiefs defense that's allowed an 81.2 QB rating against this season, 11th in the league.
Sean Mannion will start Sunday's finale against the 49ers, but Jared Goff's backup will be tough to lean on with other key starters also sitting out for rest purposes.
Derek Carr has thrown for only 522 yards with a 4:4 TD:INT over his last three games, making him a risky play Sunday on the road against a Chargers defense that held him to 171 yards with a 1:2 TD:INT in Week 6.
Case Keenum has been held to 236 yards or fewer in two of his last three games entering Sunday's contest against Chicago's eighth-ranked pass defense that has held three straight quarterbacks to 237 yards or less.
Jimmy Garoppolo remains undefeated, but the subpar offense around him suggests expectations should be tempered on the road against the sixth-ranked Rams pass defense Sunday.
Eli Manning will have a Sunday matchup against the Redskins, and although they’ve been a top-eight defense against the pass over the last six weeks, both teams have nothing to play for, which could impact playing time and/or motivation for players on both teams.
Joe Flacco has yet to reach 300 yards passing or three touchdowns in any game this season, as he faces a Cincinnati Bengals defense this week who allow the 12th-fewest fantasy points to opposing QB's.
Jay Cutler threw three interceptions the last time the Miami Dolphins faced the Buffalo Bills, and Buffalo has allowed the fewest passing scores in the NFL long with the Minnesota Vikings.
DeShone Kizer has 31 turnovers this season, as he faces a Pittsburgh Steelers defense this week who allow the seventh-fewest fantasy points to opposing QB's.
Drew Stanton will start Sunday's season finale in Seattle, but finding success won't be easy against the desperate Seahawks.
Mitchell Trubisky has never thrown for multiple touchdowns in 11 career starters entering Sunday's tilt against a Vikings defense that has allowed 173 yards or less in four straight, and only one touchdown pass in that stretch.
Jared Goff will receive rest in Week 17, as the postseason-bound Rams evidently don't believe they have much to gain by risking their starters. Sean Mannion is expected to start in his place.
Alex Smith will take a seat for Sunday's road game against the Broncos, with rookie Patrick Mahomes under center in an otherwise meaningless game for the Chiefs.
Bryce Petty has been abysmal as the starter for the New York Jets and will face a New England Patriots squad playing for home field advantage throughout the playoffs.
Taylor Heinicke made his NFL debut last week, but suffered a concussion and may not be available for Week 17 against the Indianapolis Colts.
Andy Dalton hasn't reached three touchdowns or 250 yards passing in five-straight games, as he faces a Baltimore Ravens defense this week who allow the second-fewest fantasy points to opposing QB's.
Brock Osweiler will be relegated to backup duties behind Paxton Lynch in Week 17's home game against the Chiefs.
Blaine Gabbert lost the starting quarterback job to Drew Stanton last week, and he's expected to spend Sunday's finale in Seattle on the bench.