Jonathan Stewart salvaged his season with his first 100-yard game prior to the bye week and faces a Jets defense in Week 12 that’s allowed the 10th-most rushing yards per game at 117.9.
J.D. McKissic gained all of 53 total yards last week despite serving as the three-down back for most of the second half, so expectations should be tempered with other healthy early-down options available for Sunday's match with the 49ers.
Rex Burkhead had nine touches Sunday but remains behind Dion Lewis on the depth chart at running back for the New England Patriots.
D'Onta Foreman's ruptured Achilles' tendon puts Alfred Blue in position to become the No. 2 running back for the rest of the season, beginning Week 12 against the Baltimore Ravens' 26th-ranked run defense (120.8 YPG).
Corey Clement remains in a three-man rotation at running back, but he’s posted at least 50 yards over his last three games while scoring three touchdowns; he’ll face a tough Chicago rush defense at home on Sunday.
Danny Woodhead returned from IR last week to catch five passes, but now he faces a Texans defense Sunday that have allowed just 4.1 catches and 37 yards per game to opposing running backs.
LeGarrette Blount has carried the football at least 13 times in each last six games, making him a solid, but low-upside option in Week 12 against a Chicago defense that hasn’t allowed more than 75 yards to an opposing running back over their last five games.
Alex Collins is coming off a game with 71 total yards and a touchdown last week, but he faces a Texans defense this week that has allowed the third fewest fantasy points to opposing running backs.
T.J. Yeldon has emerged as the No. 2 back over the last two weeks, which is an important development for the league's top running team, which has a banged up Leonard Fournette (ankle) entering Week 12 against the Arizona Cardinals' 10th-ranked rushing defense (101.3 YPG).
Damien Williams broke off a big run Sunday but remains in a timeshare with Kenyan Drake despite facing a New England defense this weekend allowing 121.1 rushing yards per game.
Marlon Mack remains the clear No. 2 to Frank Gore, but his play-making ability as a receiver could be useful Week 12 against the Tennessee Titans, who rank 29th in receiving yards allowed (53.7 YPG) to running backs.
Tarik Cohen has scored in two of his last three games and is coming off his highest usage in over a month, but the Bears will likely need to be creative in getting him the ball Sunday if he's to succeed against the Eagles top-ranked rush defense that allows only 71.0 yards per game.
Javorius Allen is losing his role in the Ravens offense now that Danny Woodhead has taken over the majority of third-down targets and carries since returning from IR.
Eddie Lacy rushed just three times for two yards last week even though early-down back Mike Davis exited with an injury, suggesting there's no path to extended work for the former Green Bay running back.
Mike Davis (groin) should handle early-down work if he plays Sunday in San Francisco, but don't expect much from Seattle's rushing attack regardless of who's on the field.
Giovani Bernard has just 20 rushing yards on 13 carries across his last six games, as he's fallen behind Joe Mixon on the depth chart.
Charcandrick West saw a season-high eight touches in Week 11, but his minimal role makes him a risky play at home Sunday even against a Bills defense that's surrendered a league-worst 13 rushing TDs this season to running backs.
Jalen Richard continues to split backup RB touches with DeAndre Washington, making them both very risky plays Sunday at home against a Broncos defense allowing 85.5 rushing yards a game, fourth in the league.
DeAndre Washington continues to split backup RB touches with Jalen Richard, making them both very risky plays Sunday at home against a Broncos defense allowing 85.5 rushing yards a game, fourth in the league.
Thomas Rawls was a healthy scratch last week, and his awful numbers this season suggest he won't be productive even if he's slotted back into the lineup Sunday against the 49ers.
Matt Breida scored his first rushing touchdown last game, but Carlos Hyde's backup will struggle to get enough touches to stay relevant Sunday against Seattle.
Matt Forte is likely to return from a knee injury but will face a Carolina Panthers defense allowing just 80.6 rushing yards per game, which is second in the NFL.
Chris Ivory battled an illness and played just six snaps last week, but he was losing snaps to T.J. Yeldon before that and should only be considered for Week 12 against the Arizona Cardinals if Leonard Fournette's ankle injury prevents him from playing.
Bilal Powell remains in a timeshare with Matt Forte and will face a Carolina Panthers defense allowing just 80.6 rushing yards per game, which is second in the NFL.