LeSean McCoy scored twice this past Sunday and will face a Kansas City Chiefs defense allowing 131.1 rushing yards per game, which is 29th in the NFL.
Julio Jones is in line for another big game—touchdown or otherwise—when he faces off in Week 12 against the Bucs’ second-worst secondary, allowing 276 passing yards per game.
Todd Gurley has over 1,200 yards from scrimmage and 11 touchdowns in 10 games, so expect a huge performance from him Sunday in what should be a high-scoring affair against the Saints.
Doug Baldwin's heated up with 389 yards and three touchdowns over the past five weeks, and should find further success Sunday in San Francisco against a defense that's surrendering 26.0 points per game.
Jordan Reed has missed the last two games with a hamstring injury, and he could be facing an uphill battle to be ready to play on Thursday against the Giants due to the short week.
Jarvis Landry has scored in six of the last seven games and will face a New England Patriots defense that's allowed 17 passing scores in 2017, which is 25th in the NFL.
Vernon Davis will be taking on the Giants on Thursday to face a defense that has allowed the most fantasy points to tight end position this season.
Jimmy Graham has seven touchdowns in his past six games, and should have no trouble getting into the end zone again Sunday against a 49ers team that's allowed a tight end to score in each of its past four games.
Antonio Brown is coming off a 10-catch, 144-yard and three touchdown game last Thursday, as he faces a Green Bay Packers defense this week who allow the sixth-most fantasy points to opposing receivers.
A.J. Green has touchdowns in back-to-back games, as he faces a Cleveland Browns defense this week who rank dead-last in DVOA allowed to opposing number-one receivers.
Brandin Cooks is coming off his best game as a member of the Patriots, is averaging more than nine targets over the last three contests and will face a reeling Miami Dolphins defense allowing 220 passing yards per tilt, which is 15th in the NFL.
Christian McCaffery has five touchdowns over his last six games prior to the bye week and has shown an ability to produce even with limited touches, something that could be key in Week 12 against the Jets’ tenth-worst run defense that’s also allowed the fourth-most passing touchdowns this season.
Kenny Stills exploded for 180 yards and a touchdown this past weekend and has always had a superb rapport wth backup Matt Moore, who appears likely to start Sunday against a New England Patriots defense that's allowed 17 passing scores in 2017, which is 25th in the NFL.
Devin Funchess caught a pair of touchdowns in the Panthers’ last game heading into the bye and faces a Jets secondary in Week 12 that’s allowed 20 passing touchdowns in 10 games this season.
Sterling Shepard will have a Thursday meeting against the Redskins, as he’ll hope to return to the lineup after missing last week’s game due to migraines.
Latavius Murray is averaging 5.1 yards per carry over his last two outings while scoring four times in as many games entering a Thursday contest against a Lions defense that allows 4.4 yards per carry and 12 rushing touchdowns, the second-highest total in the league.
Adam Thielen has 96 yards or more in four of his last five games while scoring in three straight, but faces a Lions pass defense on Thursday that hasn't allowed a receiver to top 58 yards in three straight while holding him to to 59 yards in Week 4.
Mark Ingram made the most of limited work (12.2 yards per carry on 11 carries) and faces the Rams’ fifth-worst run defense on Sunday.
Alvin Kamara caught six more passes lsat week to bring his total up to 48 on the season with seven total touchdowns and faces the Rams’ fifth-worst run defense in Week 12, and he could see significant work as a receiver.
Dion Lewis has established himself as the top running back for the New England Patriots, and the Miami Dolphins are allowing 116.2 rushing yards per game in 2017, which is 20th in the NFL.
Mike Wallace has touchdowns in back-to-back games, as he faces a Houston Texans defense this week who allow the third-most fantasy points to opposing receivers.
Rob Gronkowski was largely held in check this past Sunday but will have a favorable matchup with a Miami Dolphins defense that's allowed 16 passing scores in 2017, which is in the bottom half of the NFL.
Leonard Fournette told reporters following Week 11's win that he'll be dealing with an ankle injury for the rest of the season, so prepare accordingly Week 12 when the Jaguars head to the desert for matchup against the Arizona Cardinals, who allowed 134 yards rushing last week.
Mohamed Sanu snagged a highlight reel touchdown grab against the Seahawks and could find more room in Week 12 against the Bucs’ second-worst secondary, allowing 276 passing yards per game.
Le'Veon Bell has failed to crack 80 rushing yards in three-straight games, but still leads the league in carries and faces a Green Bay defense this week who allow the 10th-most fantasy points to running backs.
Rishard Matthews enters Week 12 on a bit of a streak (113 yards in Week 11, two TDs in last three games) and could build on that against the Indianapolis Colts, who rank 30th in yards allowed to wide receivers (186.1 YPG).
DeAndre Hopkins has thrived against all opponents and should produce similarly Week 12 against the Baltimore Ravens, who rank fourth in yards allowed to wide receivers (119.4 YPG).
Delanie Walker has been productive through a four-game stretch dealing with injuries, but is healthy again for Week 12 against the Indianapolis Colts, who rank 25th at 11.6 yards per reception allowed to tight ends.
T.Y. Hilton has had a feast-or-famine season and has a tasty matchup Week 12 against the Tennessee Titans, who have surrendered 15 touchdowns to wide receivers (31st).
Jamison Crowder will have an excellent Thursday matchup against the Giants, who have allowed six touchdowns to opposing wide receivers over their last four games.
A season-ending Achilles injury to D'Onta Foreman should grant more touches for Lamar Miller in Week 12 against the Baltimore Ravens' 26th-ranked run defense (120.8 YPG).
The usually steady Jack Doyle has wavered a few times this season and most recently had a costly bobble in Week 10, but has been a favorite target and should be again in Week 12 against the Tennessee Titans, who rank 14th in yards allowed to tight ends (46.7 YPG).
Jerick McKinnon's shiftiness is beginning to take a back seat to Latavius Murray's downhill style entering a Thursday tilt against the Lions, but his volume remains steady enough to offer appeal against a defense that allows 114.2 yards per game and 12 rushing scores in 11 weeks.
Kyle Rudolph hasn't topped last week's 58 yards in 10 previous weeks, but he's seen at least seven targets and caught at least five passes in six straight heading into a Thursday contest against a Detroit defense that has allowed 49 yards or more to three opposing tight ends to date.
Samaje Perine will look to build on his 117-yard, one touchdown effort when he faces an inconsistent Giants defense on Thanksgiving night.
2017 has been a tough year for DeMarco Murray, who hasn't cracked 4.0 yards per carry for five straight games entering Week 12 against the Indianapolis Colts' 15th-ranked rushing defense.
Tyler Kroft has just five catches across his last three games, but faces a Cleveland Browns defense this week who allow the third-most fantasy points to opposing tight ends.
Jordan Howard may require higher than usual volume if he's to succeed Sunday against the Eagles top-ranked run defense that allows 71.0 yards per game, with only two opposing running backs topping 38 yards against them.
Dez Bryant will have a Week 12 matchup against the Chargers, who have not allowed an opposing wide receiver to post more than 70 yards against them over their last five games.
Orleans Darkwa as a Week 12 meeting with the Washington Redskins, who have given up five touchdowns to opposing running backs over their last four games.
Frank Gore continues to hold off a challenge from rookie Marlon Mack, but runs behind a substandard offensive line as the Colts prepare for a Week 12 meeting with the Tennessee Titans, who rank fifth in rushing defense (89.2 YPG).
Davante Adams has clear rapport with Brett Hundley, and while expectations can be tempered Sunday against a Steelers pass defense that allows only 190 yards per game, Pittsburgh has allowed a 100-yard receiver in three straight.
Michael Thomas didn’t catch seven passes for the seventh time in eight games (he "only" caught six) and faces a tough challenge this week against the Rams’ top-ten passing defense.
Marvin Jones has at least 85 yards in four of his last five games, scoring four times, but faces a Vikings defense on Thursday that has allowed only six opposing receivers to score and four to top 75 yards against them.
Josh Doctson will face the Giants on Thursday after having been targeted a season-high seven times in each of his last two contests.
Paul Richardson's nose for the end zone makes him the clear-cut third option in Seattle's passing game ahead of Tyler Lockett heading into Sunday's match with a 49ers defense that's allowing 26.0 points per game.
Marqise Lee has dealt with drops and poor production early in the season, but is on a nice five-game run entering Week 12 against the Arizona Cardinals, who have allowed 11 touchdowns (26th) to wide receivers in 2017.
Carlos Hyde should see plenty of volume as both a runner and receiver, but the lack of weapons around him will make it hard to get into the end zone Sunday against the Seahawks.
Coby Fleener led the Saints in receiving in their comeback victory with 91 yards and could be in line for another strong game in Week 12 against the Rams, who’ve allowed at least 55 yards to opposing tight ends in two of the past three weeks.
Alfred Morris will be on his home field in this Thursday to face a Chargers defense that has allowed just one running back to rush for more than 63 yards against them over their last five games.