Jimmy Graham has seven touchdowns in his past six games, and should have no trouble getting into the end zone again Sunday against a 49ers team that's allowed a tight end to score in each of its past four games.
Vernon Davis will be taking on the Giants on Thursday to face a defense that has allowed the most fantasy points to tight end position this season.
Delanie Walker has been productive through a four-game stretch dealing with injuries, but is healthy again for Week 12 against the Indianapolis Colts, who rank 25th at 11.6 yards per reception allowed to tight ends.
Rob Gronkowski was largely held in check this past Sunday but will have a favorable matchup with a Miami Dolphins defense that's allowed 16 passing scores in 2017, which is in the bottom half of the NFL.
Jared Cook caught a season-low two passes in Week 11, but he seems poised for a rebound Sunday at home against a Broncos defense that's allowing almost 76 receiving yards a game to opposition tight ends, second highest in the league.
Evan Engram has a Week 12 tilt against a Washington defense that has allowed at least 59 yards to three different tight ends over the past five weeks.
Zach Ertz has seen six or fewer targets in each of his last four games after being targeted an average of 10 times in his previous four, making him a strong, but not elite, fantasy option against the Bears in Week 12.
Coby Fleener led the Saints in receiving in their comeback victory with 91 yards and could be in line for another strong game in Week 12 against the Rams, who’ve allowed at least 55 yards to opposing tight ends in two of the past three weeks.
Kyle Rudolph hasn't topped last week's 58 yards in nine previous games, but he's seen at least seven targets and caught at least five passes in six straight heading into Thursday's contest against a Detroit defense that has allowed 49 yards or more to three opposing tight ends to date.
O.J. Howard caught his fourth touchdown of the season last week and seemed to build a nice rapport with Ryan Fitzpatrick, which could pay dividends in Week 12 against the Falcons’ defense that allowed a touchdown to Jimmy Graham last week and seven receptions to Jason Witten the previous week.
Travis Kelce is coming off his fourth 100-yard performance of the season, but he may have to settle for working between the 20s in Sunday's home matchup against a Bills defense that's given up only two TDs to tight ends.
The usually steady Jack Doyle has wavered a few times this season and most recently had a costly bobble in Week 10, but has been a favorite target and should be again in Week 12 against the Tennessee Titans, who rank 14th in yards allowed to tight ends (46.7 YPG).
Tyler Kroft has just five catches across his last three games, but he faces a Cleveland Browns defense Sunday that allows the third most fantasy points to opposing tight ends.
Julius Thomas had a two-game scoring streak snapped but will look to get back into the end zone against a New England Patriots defense that's allowed 17 passing scores in 2017, which is 25th in the NFL.
Cameron Brate caught just one pass last week while O.J. Howard out-targeted him and caught a touchdown, a bad harbinger for his fantasy production in Week 12 against the Falcons in Week 12 with Ryan Fitzpatrick under center.
Charles Clay returned from injury to make three catches Sunday, and with the injury to Kelvin Benjamin should get even more looks against a Kansas City Chiefs defense allowing 259 passing yards per game, which is 28th in the NFL.
Austin Seferian-Jenkins has been held out of the end zone for three-straight games but will face a Carolina Panthers defense that's allowed 14 throwing scores in 2017, which is tied for 15th in the NFL.
Hunter Henry hasn't scored in five straight games or seen more than five targets in four straight, making him a risky play Thursday on the road against the Cowboys.
Jason Witten has a Thanksgiving Day meeting against the Chargers, who allow the second-fewest fantasy points to tight ends.
Adam Shaheen has averaged three catches and 40 yards in two games since taking over as the starting tight end from an injured Zach Miller, but he faces an Eagles defense Sunday that has allowed just 42 yards combined to opposing tight ends over the last three weeks.
After missing extended time due to a concussion, C.J. Fiedorowicz is getting his timing back entering Week 12 against the Baltimore Ravens.
Despite a great matchup, Austin Hooper caught two passes for minus-1 yard last week and faces the Bucs’ top-ten defense against opposing tight ends this week.
Marcedes Lewis is the Jacksonville Jaguars' leading red-zone target (10) entering Week 12 against the Arizona Cardinals, who rank 21st in passing touchdowns allowed (18).
Ben Watson caught his only target for 33 yards last week, and now he faces a Houston Texans defense Sunday that have allowed the ninth most fantasy points to opposing tight ends.
Ed Dickson has been very good in Greg Olsen’s absence, but the first-choice tight end’s return could come as soon as Sunday against the Jets, greatly diminishing Dickson’s value.
David Njoku has yet to record more than three catches in any game this season, as he's now splitting tight ends snaps with Seth DeValve heading into Sunday's matchup with the Bengals.
Tyler Higbee gained just five yards on five targets last week and continues to serve as more of a bit player heading into Sunday's date with the Saints.
Virgil Green saw a season-high four targets in Week 11, making him a risky play heading into Paxton Lynch's first start of the season Sunday on the road against a Raiders defense that's allowed the ninth most receiving yards in the league to tight ends.
Garrett Celek played well as the starting tight end in Week 10, but he has a much tougher matchup Sunday against Seattle and could return to a backup role if George Kittle (leg) suits up.
Eric Ebron is coming off of a season-high seven targets but has hauled in 50 or more yards only once this season entering Thursday's matchup against a Vikings defense that has allowed only two opposing tight ends to top 50 yards.
Jesse James had five catches for 21 yards and a touchdown last week, but now he faces a Green Bay Packers defense Sunday that's allowed the fewest fantasy points in the league to opposing tight ends.
George Kittle (leg) was unable to suit up in Week 10, and it's unclear if last week's bye gave him enough time to recover ahead of Sunday's game against the Seahawks.
Darren Fells has fallen back into a blocking role behind Eric Ebron entering a Thursday matchup against the Vikings.
Jermaine Gresham will likely cede some snaps to Ricky Seals-Jones after the latter's breakout performance last week, but neither will find much room with Jacksonville's league-best pass defense in town.
Ricky Seals-Jones will likely come back down to earth against the league-best Jaguars defense after scoring two touchdowns last week, but the 22-year-old tight end is worth keeping an eye on for the future.
Lance Kendricks saw three more targets than Richard Rodgers in Week 11, but he faces a Steelers defense Sunday night that has allowed only two opposing tight ends to top 45 yards this year.