C.J. Anderson continues to see a smaller than expected workload due to the Broncos' offensive struggles, but he could rebound Sunday at home against a Bengals defense allowing 123.6 rushing yards a game, 27th in the league.
Keenan Allen hasn't topped 100 yards since Week 4 or scored since Week 1, and he's unlikely to end that those droughts Sunday at home against a Bills defense that's given up only four TDs to wide receivers, the second-lowest total in the league.
Chris Thompson will take on the Saints in Week 11, but he could struggle to be productive as a receiving option out of the backfield against a defense that is not allowed more than 45 receiving yards to the running back over their last five games.
Latavius Murray has at least 15 carries in four straight games entering Sunday's matchup against a 24th ranked Rams rush defense that allows 118 yards per game but has given up just one touchdown since Week 4.
Emmanuel Sanders proved he was healthy by putting together his best performance of the season in last week's loss to the Patriots, but he could struggle to post big numbers in Sunday's home matchup against a Bengals defense allowing 214.7 receiving yards a game, fifth in the league.
Orleans Darkwa will have a Sunday matchup against the Chiefs, who are in the middle of the pack in terms of fantasy points allowed to opposing running backs.
Tyreek Hill's big-play ability has kept him productive despite not seeing more than eight targets or nine touches in a game this season, and in Sunday's road tilt he should be able to exploit a reeling Giants defense that's giving up 275.9 receiving yards a game, 29th in the league.
Alex Collins has gotten double-digit carries in five straight games, solidifying his spot as the Ravens' lead back heading into Sunday's road matchup against a Packers defense allowing 111 rushing yards a game, 17th in the league.
Alvin Kamara took a career-high 12 attempts for his first 100-yard game, and scored a touchdown for the third-straight week last weekend against the Bills and gets to face off in Week 11 against the Redskins’ bottom-dozen run defense this week.
Jordan Howard has failed to score in each of quarterback Mitchell Trubisky's first five starts, but faces a Lions defense Sunday that has allowed 10 rushing touchdowns, the second highest total in the league.
DeSean Jackson saw season-highs in targets (10) and receptions (6) with Mike Evans out last week, but has still seen six-plus targets in all but one game this season even with him in the fold, making him a solid play in Week 11 against the Dolphins middle-of-the-pack secondary (15th in passing yards allowed per game).
Kenyan Drake has nearly 100 yards from scrimmage in back-to-back contests and will face a reeling Tampa Bay Bucs defense Sunday allowing 376.3 yards from scrimmage per game, which is 27th in the NFL.
Vernon Davis will face the Saints on Sunday, and he’ll continue to be a strong fantasy option after recording at least 58 yards in six of his last seven contests.
DeVante Parker had nine targets on Monday Night Football and will face a Tampa Bay Buccaneers defense Sunday allowing 266 passing yards per game, which is 29th in the NFL.
Joe Mixon hasn't done much this season, but he should have at least the early down work to himself Sunday against the Denver Broncos thanks to Jeremy Hill's season-ending injury.
O.J. Howard wasn’t targeted a single time against the Jets’ sub-par defense against opposing tight ends and faces a Dolphins defense in Week 11 that allowed four touchdowns and two 80-plus yard games in their first eight games.
Marshawn Lynch found the end zone twice in Week 9 prior to the Raiders' bye, and he could be in line for another productive game Sunday at home against a Patriots defense allowing a league-worst 5.0 yards per carry.
Ted Ginn Jr. caught his only target (for three yards) and in the Saints’ spread-the-wealth offense, any given receiver has an incredibly low floor to go along with a high ceiling, which makes him a risky play in Week 11 against the Redskins, despite their poor performance last weekend against the Vikings.
Corey Davis' workload increased in his second game back from a hamstring injury, and has become a leading target for quarterback Marcus Mariota heading into a Thursday game in Week 11 against the Pittsburgh Steelers, who rank 19th in yards per receptions to wide receivers.
After a two-game layoff, Leonard Fournette was stopped for a season-low 33 rushing yards last week and should see similar attention in Week 11 from the Cleveland Browns' defense, which ranks fourth in the NFL defending the run.
Delanie Walker has played remarkably well while dealing with an ankle injury, but has to make a quick turnaround Week 11 for a Thursday night game against the Pittsburgh Steelers' second ranked pass defense (181.8 ypg).
Evan Engram will have a Week 11 tilt against the Chiefs, who have allowed just one touchdown to a tight end this season, so his typical upside could be limited.
Adrian Peterson, who's twice topped 130 rushing yards and twice fallen short of 30 in his four games wearing a Cardinals uniform, will be fresh Sunday in Houston after playing on Thursday Night Football last week.
With a short practice week coming up in Week 11, the younger Derrick Henry could grab a greater share of the workload in Thursday's game against the Pittsburgh Steelers' 11th-ranked run defense.
Jamison Crowder will have a Sunday tilt against the Saints, and he could find himself as Washington’s top receiver, as he’s averaged 10 targets over his last two games.
Jamaal Williams could have ample opportunities Sunday to exploit a Ravens 28th ranked rush defense that allows 125.9 yards per game with Aaron Jones (knee) out and Ty Montgomery (ribs) questionable.
Tevin Coleman could be the clear-cut starter if Devonta Freeman’s concussion keeps him out of Monday’s trip to Seattle, but Coleman will face a tough test either way as the Seahawks are in the top-dozen in terms of rushing yards allowed per game.
Ameer Abdullah is seeing increased short-yardage work and has scored in consecutive weeks entering Sunday's matchup against a Bears defense that has allowed eight rushing touchdowns to date, ranking 23rd.
Nelson Agholor will take on the Cowboys in Week 11, and he’ll be a touchdown-dependent fantasy option as he’s averaged just four targets over his last eight games.
Stefon Diggs enjoyed a rebound game last Sunday, but faces a Rams defense Sunday that has allowed only five opposing receivers to top 70 yards against them to date.
Jared Cook topped 100 yards in two of three games prior to the Raiders' Week 10 bye, but he faces a tough matchup Sunday at home against a Patriots defense allowing only 47.1 receiving yards per game to tight ends.
Melvin Gordon continues to struggle when it comes to consistently moving the chains, but he appears poised to find the end zone once again Sunday at home against a Bills defense that's allowed 11 rushing TDs to running backs this season, the highest total in the league.
Jason Witten will have a Sunday matchup with the Eagles, who allow the 10th most fantasy points per game to opposing tight ends.
Jay Ajayi will face the Cowboys in Week 11, but it’ll be difficult to project his role after he saw the third-fewest running back carries of the Eagles' RBs in his first appearance with the team in Week 9.
Wayne Gallman will have a Sunday tilt against the Chiefs, who are in the middle of the league in terms of fantasy points allowed to running backs.
Cole Beasley will be up against the Eagles in Week 11, and he’ll be a touchdown-dependent fantasy option as he averages fewer than five targets per game.
Kendall Wright has eight targets in each of his last two games, but managed only seven catches for 69 yards in that stretch entering Sunday's matchup against a Lions defense that has allowed only three opposing receivers to top 70 yards against them to date.
Cooper Kupp has taken a back seat with other Rams wide receivers posting tremendous numbers in recent weeks, but he's emerging as a high-floor option out of the slot heading into Sunday's road date with the Vikings.
Chris Godwin took advantage of Mike Evans’ absence, tying DeSean Jackson with a team-high 10 targets, but will likely see his target share decline precipitously in Week 11 with Evans back in the fold on Sunday against the Dolphins.
Kenny Golladay returned last week from a hamstring injury that had him sidelined since Week 3, and while he'll offer a solid red-zone target, he faces a Bears pass defense Sunday that has allowed only nine touchdown catches to date, the fourth fewest in the league.
Mohamed Sanu saw five targets on Sunday (third-most on the team), but in the Falcons’ balanced offense, his upside remains fairly limited in the absence of a touchdown, particularly in Week 11 against the Seahawks who are allowing just 237 receiving yards per game.
Alfred Morris will be up against the Eagles on Sunday in a difficult matchup against a defense that hasn’t allowed an opposing running back to reach 70 rushing yards over their last four games.
Samaje Perine will take on the Saints this Sunday, and he'll an increased work load with Rob Kelley set to miss this game after suffering knee and ankle injuries in last week’s contest.
D'Onta Foreman didn't get much work last week and lost some snaps to Alfred Blue, but remains the No. 2 back heading into Week 11 against the Arizona Cardinals' eighth-ranked defense against the run (97.7 ypg).
Coby Fleener saw less than half as many snaps as both Michael Hoomanawaui and Josh Hill and can be avoided in Week 11 against the Redskins, even though they’ve allowed the fourth-most points to opposing tight ends.
Doug Martin hasn’t run for more than 74 yards in a game this season and will face the Dolphins’ seventh-best run defense in terms of yards per game in Week 11.
Keelan Cole (eight catches, 172 yards) has increased his production the last three weeks and should benefit if Allen Hurns (ankle, doubtful) is unable to play Week 11 against the Cleveland Browns' 17th-ranked pass defense (230.6 ypg).
Duke Johnson has received double-digit touches in three straight games, but he gets a tough matchup Sunday at home against a Jaguars defense that's allowed under 40 receiving yards a game to opposition running backs.
Javorius Allen has seen 22 targets over his last three games, but he could lose his role as the third-down back if Danny Woodhead is ready to come off IR, and he gets a potentially tough matchup anyway Sunday on the road against a Packers defense allowing just over 40 receiving yards a game to opposition running backs.
Paul Richardson's five touchdowns and four catches of at least 37 yards this season suggest he has the big-play ability to pay off for owners Monday against the Falcons despite a low-volume role.