Tom Brady shrugged off a knee injury to throw for 286 yards and two touchdowns last weekend, and will face a Los Angeles passing defense on Sunday that was just gutted by New Orleans for 346 passing yards and five throwing scores.
Aaron Rodgers has topped 300 yards in three straight games and has 18 touchdowns over his last six games entering a matchup with a fifth-ranked Houston pass defense that allows only 209 yards per game, but has been gashed for six touchdown passes in their last two games.
Matthew Stafford has thrown just five touchdown passes in his last five games, but faces a Saints secondary that has allowed at least two touchdown passes in seven of 11 games to date.
Philip Rivers threw three touchdown passes in Week 12 for the second straight game, and now faces a Buccaneers defense that's given up 20 passing TDs this season, tied for ninth-worst in the league.
Andrew Luck, who missed Week 12 due to a concussion, practiced early this week and is expected to play in Week 13, a Monday night game against the New York Jets.
Colin Kaepernick completed 29 of 46 passes for 296 yards, three touchdowns and an interception while added 113 rushing yards on 10 carries on Sunday against the Miami Dolphins and will look to preserve his positive momentum this Sunday against a Chicago Bears defense that ranks 16th in the NFL in production allowed to opposing quarterbacks but 22nd in rushing yards allowed to those quarterbacks.
Drew Brees leads the NFL in touchdowns, completion percentage and yards and faces the Lions’ secondary on Sunday that’s allowed the third-most points to opposing quarterbacks.
Matt Ryan tore up the second-best secondary in terms of net passing yards last week against the Cardinals while only going to Julio Jones for 35 yards and faces a Chiefs defense on Sunday that allowed 368 passing yards to Trevor Siemian last week.
Russell Wilson completed 17 of 33 passes for a paltry 151 yards and two interceptions on Sunday, but his 80 rushing yards doubled his season total and suggests that he is finally healthy going into a Week 13 match-up against a Carolina Panthers defense that is tied for 22nd in fantasy production allowed to opposing quarterbacks this season.
Derek Carr had another productive game in Week 12 despite dislocating his right pinkie finger, but gets a tough matchup Sunday against a Bills defense that's allowed only 13 passing TDs this season, tied for fifth in the league.
Tyrod Taylor scored twice last weekend and will face an Oakland defense in Week 13 that's allowing 25 points per game in 2016, which is 23rd in the NFL.
Sam Bradford could surprise against a 31st-ranked Cowboys pass defense Thursday that has allowed over 400 yards through the air in two of their last three games, and has only four sacks all year.
Dak Prescott completed 17 of 24 passes for 195 yards and a touchdown plus added eight carries for 39 yards and another touchdown last Thursday, and has an even tougher matchup this Thursday against a nasty Vikings defense that ranks third in the NFL in fewest fantasy points allowed to opposing quarterbacks.
Ryan Fitzpatrick tossed two touchdown passes in his last game and has a favorable matchup on Monday night against a Colts defense that is in the bottom third in the NFL in both passing yards and touchdowns allowed through the air in 2016.
The now-accurate Jameis Winston completed 75 percent of his passes against the Seahawks last week, and faces a rejuvenated Chargers defense in Week 13 that picked off Brock Osweiler three times last week.
Eli Manning completed 15 of 27 passes for 194 yards and three touchdowns in Week 12, giving him 12 touchdowns against only four interceptions in the last four weeks, momentum he will look to carry forward against a somewhat stingy Steelers pass defense that ranks seventh in the NFL in least production allowed to opposing quarterbacks.
Ben Roethlisberger will have a Week 13 tilt against the Giants who have held the last five quarterbacks they’ve faced to one or fewer touchdown passes.
Kirk Cousins completed 41 of 53 passes for 449 yards and three touchdowns in Week 12 and is now averaging 386 yards and 2.5 touchdowns over his last four outings headed into a game against a stingy Arizona Cardinals pass defense that is fourth in the NFL in limiting production to opposing quarterbacks.
Ryan Tannehill has seven touchdown passes in his last three games and faces a Baltimore Ravens defense in Week 13 that's yielded 20 passing scores in 2016, which is tied for 19th in the NFL.
Carson Palmer completed 25 of 45 passes for 289 yards with two touchdowns and an interception on Sunday against the Atlanta Falcons, giving him eight touchdowns and six interceptions over his past four games, a ratio he hopes to improve upon this week against an average Washington Redskins pass defense that ranks 15th against opposing quarterbacks this season.
Jared Goff completed 20 of 32 passes for 214 yards and three touchdowns with one interception on Sunday against the New Orleans Saints, a solid performance in his second career start though admittedly against a poor pass defense, and he might be challenged more strenuously this week against a Bill Belichick-led New England Patriots defense even if they currently rank 22nd in production allowed to opposing quarterbacks.
Andy Dalton will be up against the Eagles in Week 13 after throwing one or fewer touchdown passes in nine of his 11 starts this season.
Matt Barkley was let down by his limited supporting cast in his first start of the season last Sunday, and assuming Jay Cutler (shoulder) remains sidelined, he'll start against a vulnerable 49ers defense that has allowed three or more touchdown passes in four of their last five games.
Carson Wentz completed 24 of 36 passes for 254 yards and an interception while adding four rushing attempts for 33 yards and a touchdown in Week 12, heading into a matchup against a Bengals pass defense that is 20th in the NFL in production allowed to opposing quarterbacks.
Joe Flacco will take on the Dolphins this Sunday after they’ve allowed three touchdown passes to Philip Rivers and Colin Kaepernick over their last three games.
Brock Osweiler, coming off his worst week of the season, remains the Houston Texans' starting quarterback, though questions about replacing him with Tom Savage have begun as the Texans prepare for Week 13 against the Green Bay Packers.
Cam Newton had a dreadful first half last week (three completions, 18 yards) and faces a Seahawks defense in Week 13 that's in the top-10 against opposing quarterbacks.
Alex Smith has thrown multiple TD passes in just three of 10 games this season, but could be productive Sunday against a Falcons defense allowing a league-worst 282.2 passing yards a game.
Blake Bortles wasn't asked to throw often last week, but had one of his better games of the season and will look to build off that in Week 13 against the Denver Broncos' top-ranked passing defense.
Andrew Luck (concussion) practiced Monday and is expected to be cleared Wednesday, putting him in line to play in Week 13 against the New York Jets, relegating Scott Tolzien back to a reserve role.