Todd Gurley has found the end zone three times in two games and is primed for another huge effort Thursday against San Francisco's porous run defense.
Jay Ajayi rushed for over 100 yards in the Dolphins' season opener and faces a New York Jets defense that has allowed the most rushing yards in the NFL thus far in 2017.
Zach Ertz will have a Week 3 matchup against the Giants, who gave up 59 yards and a touchdown to Jason Witten in Week 1.
Justin Tucker made one of his two field goal attempts and all three extra points in Week 2, and remains one of the highest scoring kicking options moving into Week 3 against a Jacksonville Jaguars squad that just gave up three field goals and four extra points against the Tennessee Titans.
Antonio Brown caught five of his 11 targets for 62 yards last week against the Minnesota Vikings, lacking big plays but still maintaining the same huge target footprint, which should lead to a major chance to pop this Sunday against a Chicago Bears defense that was just torched by Mike Evans.
Cody Parkey connected on four field goals in Miami's season opener and takes on a New York Jets squad in Week 3 that's allowing 33 points per game, last in the NFL.
Le'Veon Bell carried 27 times for 81 yards and added four receptions for four more yards, still off his usual pace but a big step in the right direction after a slow opener, and he will look to get fully on track Sunday against a Bears defense that just gave up 114 yards and a touchdown on the ground to a depleted Tampa Bay backfield in Week 2.
Keenan Allen has been productive through two games thanks to a whopping 20 targets, and he should see a high volume again Sunday at home against a Chiefs defense allowing 300 passing yards a game so far.
Stephen Gostkowski has kicked five field goals in two games this season, and should get plenty of work against a Houston Texans defense that's allowed just two offensive touchdowns in 2017.
Kareem Hunt has five TDs and 355 yards from scrimmage through his first two NFL games, making him a must-start Sunday in a road matchup against a Chargers defense that's surrendered over 125 rushing yards a game so far.
DeVante Parker was the leading receiver for the Miami Dolphins in their season opener, and is a great bet to explode against a suspect New York Jets defense which has allowed five passing touchdowns through two contests.
Chris Boswell made all four field goals and both extra points last week against the Minnesota Vikings, and takes that momentum into a matchup Sunday with a Chicago Bears squad that just allowed three field goals and three extra point attempts to the Tampa Bay Buccaneers.
Ty Montgomery has 39 touches and three touchdowns through two weeks, and now faces a Cincinnati defense Sunday that has allowed 162.5 rushing yards per game.
Austin Hooper crashed back down to earth last week (two receptions, seven yards), but faces a Lions defense in Week 3 that allowed Evan Engram to lead the Giants in all receiving categories last week.
Melvin Gordon has scored in both games so far this season, and he should have success again Sunday against a Chiefs defense that's allowed three rushing TDs and 115.5 rushing yards a game so far in 2017.
Jordan Reed will face the Raiders on Sunday, as he hopes to suit up after suffering a shoulder injury in last week's contest.
Travis Kelce scored his first touchdown and topped 100 yards for the first time in 2017 last week, and he should be productive again Sunday despite the fact he's facing a Chargers defense he has yet to find the end zone against in six career games.
Devin Funchess looks best-poised to step in the void left behind by Greg Olsen (broken foot) as they take on the Saints’ secondary on Sunday that allowed 447 yards to Tom Brady last week.
Jay Cutler looked surprisingly comfortable as a Miami Dolphin in his debut last weekend, and will face a New York Jets defense that has allowed five passing touchdowns through two games in 2017.
Chris Hogan will get plenty of opportunities thanks to a injury-plagued receiving corps, even against a Texans defense that is allowing only 169 passing yards per game thus far.
Matt Prater has only attempted two field goals in as many weeks, but a likely high-scoring affair against the Falcons in Week 3 should afford him additional scoring opportunities.
DeAndre Hopkins likely will see another week of double-digit targets Sunday against the Patriots as injuries at wide receiver and tight end have thinned the Texans' receiving corps significantly.
Aaron Rodgers could a little riskier of a play in Week 3 against a Bengals defense that hasn't allowed more than 125 yards passing through two weeks, especially if Jordy Nelson (quad) or Randall Cobb (shoulder) are forced to sit.
Lamar Miller and the Texans face the Patriots' 27th-ranked rushing defense Sunday in what should be another run-heavy attack as the team protects rookie quarterback Deshaun Watson.
Derek Carr picked apart the Jets in Week 2, and seems poised for another efficient performance Sunday on the road against a Washington defense allowing a 94.3 QB rating through two games.
Martavis Bryant caught three of four targets for 91 yards and a touchdown last week against the Minnesota Vikings, a huge step up from his quiet opener and a sign that he is at full speed again going into this Sunday's matchup with a Chicago Bears defense that just got torched by the Tampa Bay Buccaneers passing game.
Kelvin Benjamin rekindled the spark between him and Cam Newton as he played the role of Greg Olsen as primary safety blanket with aplomb and faces a Saints secondary in Week 3 that allowed Tom Brady to throw for 447 yards last week.
Davante Adams could serve as the team's top wide receiver as Jordy Nelson deals with a quad injury, which would make him a high-volume option against a limited Bengals secondary that could be without Adam Jones due to an arm injury.
Kirk Cousins will face a Raiders defense in Week 3 who have allowed just two touchdown passes to opposing quarterbacks over the first two weeks of the season.
Jarvis Landry had a staggering 13 receptions in the season opener for the Miami Dolphins, and will face a New York Jets defense allowing 8.1 yards per passing attempt thus far in 2017, which is 25th in the NFL.
Greg Zuerlein should get more opportunities than normal Thursday in San Francisco, as the 49ers' offensive woes give opponents excellent starting field position.
Tom Brady is coming off a scintillating performance but faces a Houston Texans defense that's allowed just one passing touchdown through two games in 2017.
Golden Tate should see plenty of looks against a beatable Falcons secondary in a game that figures to be high scoring, helping offset his current 9.4 yards per catch through two weeks.
Cairo Santos is perfect so far in 2017, and he should continue riding shotgun for a hot Chiefs offense Sunday against a Chargers defense that's given up five field goals through two games.
Cam Newton was sacked six times against the Bills, but faces a Saints secondary on Sunday that allowed Tom Brady to throw for 447 yards last week.
A.J. Green caught five passes for 67 yards in Week 2, another mildly productive game that ended without triple-digit yardage or a score, but he will look to bounce back Sunday against a Green Bay Packers secondary that gave up 108 yards to Julio Jones in Week 2.
Matthew Stafford has six touchdowns through two games and an inviting matchup Sunday in a game that could become a shootout against a Falcons secondary that has allowed 278 yards per game.
Ben Roethlisberger completed 23 of 35 passes for 243 yards and two touchdowns last week against the Minnesota Vikings, and he has a good matchup this Sunday against a Chicago Bears defense that Jameis Winston was picking apart before taking his foot off the gas in a blowout.
Hunter Henry caught all seven of his targets against the Dolphins, and he should continue to be one of Philip Rivers' top options Sunday at home against a Chiefs defense allowing 70 receiving yards a game to tight ends so far.
Christian McCaffery struggled last week against the Bills’ physical front, but faces a Saints defense in Week 3 that allowed 12 receptions for 137 yards and a touchdown to the Patriots’ cadre of backs last weekend.
Marcus Mariota threw 27 passes in Week 2, down from 41 the previous week, and will look to rely on the running game once again in Week 3 at home against the Seattle Seahawks.
Mohamed Sanu caught five passes for 85 yards and has already seen 15 targets this season as he’s firmly ensconced as the Falcons’ No. 2 option in the passing game, and he'll look to extend his success in Week 3 against the Lions.
Amari Cooper wasn't needed in Week 2's dismantling of the Jets, but he should be much more involved Sunday on the road against a Washington defense allowing almost 280 passing yards a game so far.
Jamison Crowder will have a Sunday tilt against the Raiders, who have held opposing passing attacks to just 211 yards per game.
Jesse James caught four of five targets for 27 yards last week against the Minnesota Vikings, a similar load as in the opener but without the red-zone looks, and he will look to get back into the end zone this Sunday against a poor Chicago Bears defensive unit.
J.J. Nelson will look to find pay dirt for the third consecutive week against Dallas on Monday Night Football.
Julio Jones had his first 100-yard game of the season, but faces a Lions secondary on Sunday that held a hobbled Odell Beckham Jr. to four receptions for 36 yards.
Emmanuel Sanders found the end zone twice against the Cowboys, and his target volume gives him a solid production floor heading into a road matchup Sunday against a Bills defense that's allowed a stingy 68.7 QB rating so far.
Demaryius Thomas has seen eight targets in two straight games to begin 2017, and should remain a high-priority target for Trevor Siemian in Sunday's road tilt against a Bills defense that's allowed a stingy 68.7 QB rating so far.
Ryan Succop is enjoying a nice start to the season, tied for the lead among placekickers with 23 points entering Week 3 against the Seattle Seahawks.