Ben Roethlisberger will have a Week 17 tilt against the Browns, though it’s possible that the team will choose to rest him in a meaningless game.
Tom Brady and the New England Patriots can clinch home field throughout the playoffs with a win on Sunday over the Miami Dolphins, whose defense has allowed 27 passing touchdowns in 2016, which is tied for 25th in the NFL.
Aaron Rodgers has three or more touchdowns in two of his last three games and hasn't thrown an interception in six straight entering a Sunday night showdown with Detroit, whom he threw for four scores against in Week 3.
Matthew Stafford has failed to throw a touchdown pass in two straight games, but gets a Packers defense at home Sunday that ranks 30th in touchdown passes allowed, and one which he carved up for 385 yards and three scores in a Week 3 meeting.
Kirk Cousins faces the 22nd-ranked Giants secondary Sunday with a Redskins playoff berth potentially hanging in the balance.
Carson Wentz will close out his rookie season Sunday with a plus matchup against the 28th-ranked Cowboys secondary.
Russell Wilson closes the regular season Sunday against a 49ers team that has allowed the most points in the league.
Tyrod Taylor had three touchdown passes last weekend, and will face a reeling New York Jets defense on Sunday that's allowed 30 passing scores in 2016, which is tied for 30th in the NFL.
Drew Brees is just 142 yards away from his fifth 5,000-yard season, and faces the Falcons’ second-worst fantasy secondary on Sunday to accomplish it.
Eli Manning's Giants clinched a playoff spot last week, but he's still expected to be out there Sunday against a Redskins defense he burned for 350 yards back in Week 3.
Philip Rivers threw multiple TD passes for the eighth straight game last week, but gets a tough matchup Sunday against a Chiefs pass defense that ranks third in QB rating against.
Sam Bradford quietly has 290 yards or more in three straight games, and while his scoring upside is limited against a Bears defense that has allowed only two touchdown passes in the last four weeks, Bradford's floor seems safer than many other quarterbacks in Week 17 who could share snaps in games that matter little to the playoff picture.
Blake Bortles is coming off his best game of the season and is playing for his job as the franchise's quarterback of 2017 when they face the Indianapolis Colts' 24th-ranked passing defense in Week 17.
After signs of looking like a game manager, Jameis Winston’s reverted into being a gunslinger, throwing for the eighth-most touchdowns (27) and the second-most interceptions (17) on the season, and he could find himself in a shootout in Week 17 against the Panthers.
Matt Moore has six touchdown passes in two starts, but faces a New England defense on Sunday that's allowed just 19 passing scores in 2016, which is tied for seventh in the NFL.
Andrew Luck and the Indianapolis Colts had their playoffs hoped dashed last week had nothing but pride left in Week 17 against the Jacksonville Jaguars, who rank third in passing defense (210.3 ypg).
Alex Smith threw less than two TD passes last week for the eighth straight game, but could rebound Sunday when he faces a Chargers defense he had his best performance of the season against back in Week 1.
Cam Newton’s thrown for fewer than 200 yards in four of his past six games, and has run for just 92 yards in those games, turning him from MVP to early-round disappointment in a season’s time, and he's not a strong fantasy option in Week 17 against the Bucs.
Dak Prescott may not get a chance to build on his excellent 23:4 touchdown to interception ratio with Dallas likely to rest its key contributors Sunday against the Eagles.
Joe Flacco will take on the Bengals this Sunday after throwing for 234 yards and one touchdown when he met this defense in Week 13.
Matt Cassel draws the start for the final game of the regular season with Marcus Mariota (fibula) unable to play Week 17 against the Houston Texans' second-ranked passing defense (206.2 ypg).
Carson Palmer managed 288 yards on 36 passing attempts in his last meeting with the Rams, but is unlikely to get as many attempts against the league's ninth-ranked pass defense Sunday.
Andy Dalton will face the Ravens in Week 17, but he’s expected to be without AJ Green and Tyler Eifert in what will be a meaningless season finale for the Bengals.
Tony Romo hasn't played all season, but would get the reps under center should the 13-2 Cowboys choose to rest rookie starter Dak Prescott for Sunday's season finale in Philadelphia.
Trevor Siemian threw for 283 yards and two TDs in Week 9's meeting with the Raiders, but with the Broncos eliminated from the playoffs and in talent evaluation mode, he could give way to Paxton Lynch at some point in Week 17.
Tom Savage will make his second career NFL start in Week 17 against the Tennessee Titans, who rank 31st in passing defense (270.9 ypg).
Matt Barkley has topped 300 yards in consecutive games, but has eight interceptions in that span and should see less opportunity Sunday against Minnesota, as the Vikings are unlikely to jump on the Bears early, and thus not necessitating a pass heavy offense.
Cody Kessler could be pressed into action this week of Robert Griffin isn't cleared from the concussion he suffered last week.
Marcus Mariota suffered a broken fibula and will miss Week 17's game against the Houston Texans.
Bryce Petty tore the labrum in his non-throwing shoulder and will miss the final game of the season.
Jared Goff has shown little ability to beat NFL defenses, so expect him to have trouble moving the ball Sunday against the fifth-ranked Cardinals secondary.
Paxton Lynch hasn't played since Week 13, but could see action Sunday against the Raiders with the Broncos eliminated from the playoffs and in talent evaluation mode.
Matt McGloin will get the start Sunday as the Raiders look to clinch the AFC West title, but has a daunting matchup against a Broncos defense allowing a league-low 69.5 QB rating against.
Brock Osweiler will serve as a well-paid backup for the second straight game in Week 17 against the Tennessee Titans.
Matt Ryan completed better than 80 percent of his passes last week, but faces a Saints secondary on Sunday whom he threw for the second-fewest yards of any game this season back in Week 3.