Theo Riddick is coming off of a season low in touches and yards and now faces a Bears defense that is allowing 3.9 yards per carry and defended him well in Week 4, allowing him to gain 58 total yards
Isaiah Crowell will be up against the Bengals in Week 14, after they’ve held every running back they’ve faced over the last five weeks to 87 yards or fewer.
Kenneth Dixon will have a Week 14 matchup against the Patriots after posting at least 77 total yards in three of his last four games, though he’s yet to find the end zone in his rookie campaign.
Derrick Henry has fresh legs while DeMarco Murray deals with a toe injury and a heavy workload entering 14 against the Denver Broncos, who rank 28th in rushing defense.
The Jacksonville Jaguars' top three running backs are dealing with injuries, but Yeldon was able to play through his last week, making him the best of a bad lot entering Week 14 against the Minnesota Vikings.
Mike Gillislee swiped two touchdowns from teammate LeSean McCoy last weekend, and faces a Pittsburgh defense in Week 14 that's yielded 10 rushing scores in 2016, which is tied for 19th in the NFL.
Ty Montgomery resurfaced to lead the Packers in rushing last week, and his dual position eligibility give him a shot at relevance against a tough Seahawks defense that is allowing only 99.3 yards per game rushing.
Chris Ivory missed last week's game due to a hamstring injury and is questionable entering Week 14 against the Minnesota Vikings, who rank 17th in rushing defense.
Paul Perkins had seven carries for 38 yards to lead the New York Giants in rushing last Sunday, though he still played a lesser role in the offense than starter Rashad Jennings due to the latter's receiving and blocking abilities, making Perkins a risky play against a tough Dallas Cowboys defense that is fourth in the NFL in production allowed to opposing running backs.
Rex Burkhead will take on the Browns this Sunday after posting at least 48 yards in each of his last two games since taking over for Giovani Bernard.
Bilal Powell touched the ball just once on Monday Night Football, but has a chance to rebound on Sunday against the league's worst rushing defense of the San Francisco 49ers, a unit that's allowed a staggering 169.3 rushing yards per game in 2016.
Duke Johnson will have a Week 14 tilt against the Bengals, though he hasn’t had more than eight touches in any of his last five games.
Playing from behind, the Saints ran the ball a total of 12 times last week and their willingness to abandon the run game bodes poorly for Tim Hightower on Sunday against the Bucs, who have allowed just one 100-yard rusher this season.
Jerick McKinnon scored and averaged 4.6 yards per carry last week, two things he hadn't done since Week 4 against the Giants, giving him a but of momentum entering Sunday's matchup with the Jaguars 24th ranked rush defense that allows 115.6 yards per game.
Matt Asiata saw a three-game scoring streak snapped last week and has six or fewer carries in three straight games giving him minimal upside against a Jaguars 24th ranked rush defense that allows 115.6 yards per game.
Wendell Smallwood was held to 19 yards on eight carries and three unsuccessful targets last Sunday against the Cincinnati Bengals, and with Ryan Mathews expected to return this week Smallwood is facing a return to a pure back-up role against the Washington Redskins.
Jonathan Grimes, along with Alfred Blue, will get some touches each week, but he's no threat to Lamar Miller's top spot in the backfield entering Week 14 against the Minnesota Vikings.
Corey Grant is a little used on offense, but has the distinction of being the healthiest running back on the Jacksonville Jaguars' roster entering Week 14 against the Minnesota Vikings' 17th-ranked rushing defense.
Christine Michael saw an expanded role in his second week with the Packers last Sunday, but will continue to split carries with at least Ty Montgomery entering a matchup with his former team in the Seahawks, who allow only 99.3 yards per game on the ground.
Alfred Blue returned to action last week after missing two games with a calf injury, but needs a significant injury to Lamar Miller to have any value in Week 14 against the Indianapolis Colts, who rank 20th in run defense.
Robert Turbin is Frank Gore's touchdown stealer, having scored four times this season as the Indianapolis Colts prepare for the Houston Texans, who have been susceptible to the running game.
Dwayne Washington remains a complimentary piece to the Lions limited rushing attack, giving him next to no appeal against a Bears defense that allows just 3.9 yards per carry.
Justin Forsett hasn't seen action since Week 7, but could see a handful of snaps right away as Devontae Booker's main backup given familiarity with Gary Kubiak's offense from their days together in Baltimore.
James Starks saw just four carries last week and appears to be on the outside looking in of a three-man committee with Ty Montgomery and Christine Michael entering a matchup with the Seahawks 14th ranked run defense.