Aaron Rodgers indicates he'll start for the Packers in Week 18 despite the team already locking up the No. 1 seed, and while it's an inviting matchup against a Lions team allowing 8.0 yards per attempt and one he lit up for four touchdowns previously, it remains possible he'll have to do his damage in far less than four quarters.
Chase Edmonds has posted at least 82 yards in each of Arizona's last two games, but if James Conner (heel) returns, he could see a reduced workload in a Week 18 matchup against a Seattle defense that's allowed the fifth-most fantasy points to opposing RBs over the last five weeks.
Jason Myers had 15 points in Seattle's last game, but that was his first double-digit performance of the season, and he remains a low-floor fantasy option in a Week 18 matchup against a Cardinals team that's allowed 8.5 points per game to opposing kickers over the last five weeks.
Justin Herbert has thrown multiple TDs in six of the last seven games, and he'll need to be productive again in Week 18 with a wild-card spot on the line as the Chargers take on a Raiders defense that ranks 10th in passing yards per game allowed.
Mason Crosby is coming off of a season-high 13 points for the Packers, making multiple field goals for the first time in four weeks, and while his 3-point tries aren't consistent thanks to a highly efficient offense, there could be more stalled drives in Week 18 against the Lions if Green Bay rests starters eventually, creating some upside against a defense that's allowed 12 opposing kickers to go for at least eight points against them.
Austin Ekeler has found the end zone in seven straight games, piling up 655 scrimmage yards and 10 total TDs over that stretch, and he doesn't figure to slow down in Week 18 with a wild-card spot on the line as the Chargers take on a Raiders defense he torched for 145 yards and two TDs back in October.
Daniel Carlson has kicked at least three field goals in four of the last six games, giving him significant upside in Week 18 as the Raiders face a Chargers team allowing 26.5 points a game, tied for 26th in the league.
Matthew Stafford has a 5:6 TD:INT ratio over the Rams' last three games, but he should have a strong scoring floor in a Week 18 matchup against a 49ers defense that's allowed 1.6 TD passes per game and the 16th-most fantasy points to opposing QBs over the last five weeks.
Anthony Schwartz has just nine catches all year for the Browns, but in Week 18, he gets a Bengals defense that ranks 24th in pass DVOA so far in 2021.
Davante Adams has scored in four straight (six total TDs) while topping 100 yards in five of his last six for the Packers entering a Week 18 matchup against a Lions defense that's allowed seven 100-yard receivers to date and 8.0 yards per pass attempt.
Amon-Ra St. Brown continues to enjoy success behind heavy volume, seeing 11 targets in five straight weeks, and with the Lions' receiving corps reduced by injury, there's little reason to think that stable floor changes in a Week 18 matchup against a Packers' defense that allows just 6.5 yards per attempt and 213.7 yards per game.
Marquez Callaway posted six receptions for the second time in his last three games a s the leads of the Saints' wide receiver corps, and he could be in for another big workload in a Week 18 matchup against Atlanta -- particularly if Tre'Quan Smith remains sidelined.
Aaron Jones hasn't topped 13 carries since Week 8, and heavy volume for the Packers in a Week 18 contest against the Lions seems unlikely with minimal to play for, but his continued involvement in the passing game has created a stable floor, having topped 70 total yards in three straight, paired with 115 and four TDs against Detroit earlier in the year.
AJ Dillon is coming off his first double-digit carry outing in three weeks, and seems destined for a heavy workload for the Packers in Week 18, either with Aaron Jones getting limited work with the No. 1 seed clinched, or as a hammer to ice the game once a comfortable lead is built, giving him upside against a Lions team that's allowing 135.8 yards per game.
Van Jefferson is averaging 31 receiving yards over the Rams' last three games, and he'll likely need to find the end zone to have upside in a Week 18 matchup against a 49ers defense that's allowed 183 receiving yards per game and the third-most fantasy points to opposing WRs over the last five weeks.
Laquon Treadwell has been Jacksonville's most productive wide receiver down the stretch with over 50 yards in each of his past six games, but he's still searching for his first touchdown of the season heading into the Week 18 season finale against a Colts secondary that's been burned for 19 touchdowns by wide receivers.
Jarvis Landry has topped 75 yards just once all season for the Browns, but in Week 18, he gets a Bengals defense that ranks 24th in pass DVOA so far in 2021.
Josh Jacobs has piled up 570 scrimmage yards and three touchdowns over the last six games, and he figures to be productive again in Week 18 with a wild-card spot on the line as the Raiders take on a Chargers defense that ranks in the bottom four in rushing yards per game allowed and rushing TDs allowed.
Christian Kirk has recorded at least 79 yards in three of the Cardinals' last four games, and he should continue to be a focal point of the passing attack despite a Week 18 matchup against a Seattle defense that's allowed just two receiving TDs and the eighth-fewest fantasy points to opposing WRs over the last five weeks.
Robby Anderson has recorded 30 or fewer passing yards in two of his four games since the Panthers' bye week, and he now heads into a Week 18 matchup against a Tampa Bay defense that has allowed the ninth-most receiving yards to opposing wide receivers this season.
Matt Gay had his second game of the season with fewer than eight points last week for the Rams, but he'll remain one of the steadiest kicking options in the league in a Week 18 matchup against a 49ers team that's allowed 6.4 points per game to opposing kickers over the last five weeks.
Tyreek Hill has been held below 80 receiving yards and without a touchdown in four of five games since Kansas City's bye, making him a high-risk, high-reward play in Week 18 against a Broncos defense that ranks seventh in passing yards per game allowed this season.
Chase McLaughlin has missed six of his 21 field-goal tries for the Browns this season, and in Week 18, he gets a Bengals defense that has allowed 22.2 points per game in 2021, ranking them in the middle of the pack.
Javonte Williams is coming off his worst performance since the Broncos' Week 11 bye, but the rookie will look to rebound in Week 18 against a Kansas City defense that ranks 28th in yards per carry allowed.
Derek Carr has thrown one touchdown or fewer in seven straight games, giving him a limited ceiling in Week 18 with a wild-card spot on the line as the Raiders face a Chargers defense that held him under 200 passing yards in their first meeting, the only team to do so this season.
Lamar Jackson has thrown for at least 235 passing yards in all but two of his healthy games this year for the Ravens, and in Week 18, he gets a Steelers defense that ranks 15th in DVOA so far in 2021.
Deonte Harris earned only two targets in his return from a three-game suspension and he'll now head into a Week 18 matchup against an Atlanta defense that has allowed the seventh-most fantasy points to opposing wide receivers this season.
Patrick Mahomes has a sharp 10:1 TD:INT over the last four games, but he faces a tough challenge in Week 18 as Kansas City takes on a Broncos defense that held him below 200 passing yards and without a TD in their first meeting, the only defense this season to accomplish that feat.
Elijah Mitchell returned from injury in the 49ers' last game, and he posted 130 total yards and a touchdown, and he'll likely continue to see heavy volume in a Week 18 matchup against a Rams defense that's given up 60 rushing yards and the 14th-fewest fantasy points per game to opposing RBs over the last five weeks.
Boston Scott scored twice last game for the Eagles while leading the squad in rushes, and with Philadelphia clinching a playoff berth it is unlikely starter Miles Sanders will be rushed back in Week 18, making Scott an intriguing play versus a Cowboys defense allowing 110.6 rushing yards per contest, which is 16th in the NFL.
Dare Ogunbowale scored a receiving touchdown last week to complement his rushing score from the previous game, and he'll continue to work as the primary option in Jacksonville's backfield in Week 18 against a Colts defense that has limited running backs to 12 scrimmage touchdowns.
Cairo Santos has struggled for consistent opportunities in a low-scoring Bears offense, making multiple field goals just three times in his last seven outings heading into a Week 18 contest against a Vikings defense that's allowed 12 opposing kickers to go for at least eight points against them.
Sammy Watkins does not have a catch in any of his last three games for the Ravens, and in Week 18, he gets a Steelers defense that ranks 13th in pass DVOA in 2021.
Rashaad Penny has posted at least 135 yards and one touchdown in three of Seattle's last four games, and he should continue to see volume in a Week 18 matchup against a Cardinals defense that's allowed 105 rushing yards per game and the 11th-fewest fantasy points to opposing RBs over the last five weeks.
Davis Mills has topped 300 passing yards three times in an up-and-down rookie season for the Texans, and he'll be motivated to close out the season on a high note and make his case for the starting job next season in Week 18 against a Titans defense that has allowed 21 passing touchdowns but also notched 16 interceptions.
DJ Moore has earned a minimum of eight targets in each of his last five games as the Panthers' head into a Week 18 matchup against a Tampa Bay defense that has allowed the fourth-most receptions to opposing wide receivers this season.
Nico Collins scored his first career touchdown two weeks ago with Brandin Cooks sidelined, but he has delivered modest production as Houston's No. 2 wide receiver with Cooks healthy, though perhaps a Week 18 matchup with a Titans defense that has allowed 2,966 yards to wide receivers - second-most in the league - will help Collins close out his rookie season on a high note.
Russell Gage has posted four or fewer receptions in three of his last four games as the Falcons head into a Week 18 matchup against a New Orleans defense that has allowed the 10th-most receptions to opposing wide receivers this season.
Marquez Valdes-Scantling had only one catch in his return to the Packers lineup, and remains a boom or bust option, topping 97 yards in two of his last five outings, and going for 20 or less at the same ratio entering a Week 18 matchup against a Lions secondary that allows 8.0 yards per pass attempt.
Michael Carter has at least 60 total yards in seven of his last eight games for the Jets, and in Week 18, he'll get a Buffalo defense that ranks 15th in rush DVOA so far in 2021.
Hunter Renfrow has seen his volume decline in recent weeks but has compensated by scoring a TD in three of the last four games, making him a dependable option in the Raiders' Week 18 clash with a Chargers defense that ranks in the middle of the pack in passing yards per game allowed and passing TDs allowed.
Evan McPherson has missed five of his 33 field-goal attempts this season for the Bengals, and in Week 18, he gets a Browns defense allowing 22.2 points per game, ranking them in the middle of the pack.
Rhamondre Stevenson has at least 75 total yards in five of his past seven games for the Patriots, and in Week 18, he'll get a Dolphins defense that ranks 13th in rush DVOA so far in 2021.
Saquon Barkley notched his first 100-yard rushing performance since the end of the 2019 campaign for the Giants and will be relied upon heavily in Week 18 versus a fairly stingy Washington run defense allowing 105.1 rushing yards per contest, which is eighth in the league.
Dalvin Cook struggled last week with the Vikings using a backup quarterback, and could need Kirk Cousins to return in Week 18 if he's to find more running room against a Bears defense that allows 4.4 yards per carry, but bottled Cook up for 3.2 ypc three weeks prior.
Damien Harris has scored 14 touchdowns this year for the Patriots, and in Week 18, he'll get a Dolphins defense that ranks 13th in rush DVOA so far in 2021.
Dustin Hopkins has averaged two made field goals and three PATs over the last five games, and he figures to get plenty of opportunities again in Week 18 as the Chargers face a Raiders team allowing 25.4 points a game, 24th in the league.
Ryan Succop has made his last six field-goal attempts heading into the Buccaneers' Week 18 matchup against the Panthers.
Antonio Gibson could return from the reserve/COVID-19 list for Washington in Week 18 and would have a tasty matchup versus a reeling Giants defense allowing 122.9 rushing yards per tilt, which is 23rd in the league.
A.J. Green has posted at least 64 yards in three of Arizona's last four games, and he should remain productive despite a Week 18 matchup against a Seattle defense that's allowed just two receiving TDs and the eighth-fewest fantasy points to opposing WRs over the last five weeks.