Melvin Gordon failed to find the end zone Sunday for the first time since Week 1 but still topped 100 scrimmage yards for the sixth-straight game, and he should be in line for a huge performance once again in Week 12 as the Chargers face a Cardinals defense that's given up the second-most rushing yards in the league.
Odell Beckham has four touchdowns in his last four games for the Giants and will face a banged up Eagles secondary in Week 12 allowing 277 passing yards per game in 2018, which is 26th in the NFL.
Julian Edelman broke the 100-yard barrier against the Titans in one of the lone bright spots of the Patriots embarrassing loss prior to the bye week but should come back with a vengeance against their rivals, the Jets, in Week 12, who have found themselves wholly unable to cover underneath receivers, a role Edelman relishes.
Ezekiel Elliott is averaging 194 scrimmage yards over the past two games for the Cowboys and will face a Washington defense in Week 12 allowing 356.9 scrimmage yards per contest in 2018, which is 15th in the NFL.
Michael Thomas has been as hot as any receiver in the league with 373 yards and four touchdowns over the past three weeks, so the sky's the limit for him on Thanksgiving in Week 12, when a Falcons team allowing 284.1 passing yards per game pays a visit to New Orleans.
Before the 49ers' bye last week, Matt Breida posted his third game with at least 117 scrimmage yards, and in Week 12 he'll face a Tampa Bay defense that's given up at least 138 yards and two TDs to three different RBs over their last four games.
Mike Evans is 43 receiving yards away from topping 1,000 for the fifth consecutive season to open his career, and his average of 95.7 per game suggests he should have no problem racking up the necessary yardage when Tampa Bay hosts the 49ers in Week 12.
DeAndre Hopkins stretched his touchdown streak to five games last week and has eight for the season heading into Week 12 against the Titans, who rank 25th in YPG allowed to WRs.
Julio Jones has over 100 yards and a touchdown in each of his past three games ahead of a Week 12 Thanksgiving clash between his Falcons and a Saints defense that's allowed a league-high 2,029 yards to wide receivers this season.
A.J. Green has missed the last two weeks with a toe injury but has a chance to be back in Week 12 and could be set for another big game when the Bengals face the Browns, who give up the third-most receiving yards per game.
With Indianapolis' offensive line protecting Andrew Luck -- no sacks in his last 214 attempts -- he has a 17:4 TD:INT ratio and a four-game winning streak heading into Week 12 against Miami's 19th-ranked pass defense.
Russell Wilson has thrown 16 TD passes over his last six games, and he should be in position to repeat his success in Week 12, when the Cardinals face a Panthers defense that's given up 10 TD passes over their last three games.
Justin Tucker hit all three of his field goals and his extra point attempt last week, and he should have plenty of opportunities in Week 12 when the Ravens take on the Raiders, who give up the third-most points per game.
Matt Ryan has 285 or more passing yards in each of his last eight games, including a 374-yard, five-touchdown performance when the Falcons and Saints faced off earlier this season, so he's primed for success in their Week 12, Thanksgiving rematch.
George Kittle has posted at least 83 yards in three of the 49ers' last four games, and he'll have a great Week 12 matchup against the Bucs, who have allowed the second-most points per game to TEs.
Saquon Barkley scored three times last game for the Giants and racked up over 150 scrimmage yards; he has an extremely favorable matchup in Week 12 versus an Eagles defense that he torched in October for 219 yards and a touchdown.
Tom Brady will look to break out of his recent slump, throwing just five touchdown passes in his last five games, against a Jets defense in Week 12 that allowed Matt Barkley to look like Drew Brees prior to the bye week.
Wil Lutz brings an elite combination of accuracy and workload into the Week 12 Thanksgiving showdown with Atlanta -- the Saints average 37.8 points per game and he's only missed once on 22 field-goal tries this season.
Alvin Kamara has been seeing a near-even split with Mark Ingram recently, but there's more than enough room in the Saints' explosive offense for both running backs to thrive, as evidenced by Kamara's 1,127 scrimmage yards and 15 touchdowns coming into this Week 12 matchup with the Falcons.
Drew Brees' owners can say thanks for the veteran quarterback's sparkling 25:1 touchdown to interception ratio when they watch his Saints host a Falcons team that's allowing 284.1 passing yards per game on Thanksgiving in Week 12.
Josh Gordon saw 12 targets against the Titans, but mustered just four receptions; however, he should find plenty of opportunities against a Jets defense in Week 12 that's allowed the sixth-most fantasy points to opposing receivers including a pair of receivers who broke 90 yards on the Bills with their third-string quarterback.
Antonio Brown caught five of his 13 targets for 117 yards and a touchdown last week, and now he has a touchdown in every week this season but one, and in Week 12, he'll have a neutral matchup when the Steelers face the Broncos who have given up the 19th most fantasy points per game to receivers.
Kirk Cousins and the Vikings face a Packers defense in Week 12 that ranks fifth against the pass, allowing just 223 yards per game, but they've allowed six multi-touchdown pass games and Cousins had a season-high 425 yards and four scores against them in an earlier meeting.
Christian McCaffrey has over 50 rushing yards and over 50 receiving yards in each of his past three games, so he should see heavy involvement in Carolina's offense regardless of game script when the Seahawks come to town in Week 12.
Zach Ertz was held to season lows last game for the Eagles but has a favorable matchup in Week 12 versus a Giants defense allowing 256 passing yards per contest, which is 22nd in the NFL.
Adam Thielen has been limited to 88 total yards over the last two weeks after topping 100 yards in each of the Vikings first eight games, but has still seen 19 targets in that span, suggesting a bounce back could be in store in Week 12 against a Packers secondary he 12 balls for 131 yards against earlier in the year.
Michael Badgley missed an extra point in Sunday's loss to the Broncos, his first missed kick of the year, but he could get plenty of opportunities for redemption in Week 12 as the Chargers host a Cardinals defense allowing 24.8 points per game, 17th in the league.
Leonard Fournette had a big workload for a second-straight game last week, so the hamstring appears healthy, and he'll lead Jacksonville's run-oriented attack Week 12 against Buffalo's 10th-ranked run defense.
Lamar Miller went over 100 yards from scrimmage for the third time in four games and is the main beneficiary of Houston's run-oriented attack heading into Week 12 against the Titans' 11th-ranked run defense.
Mark Ingram has eclipsed 100 rushing yards in each of his past two games and scored two touchdowns in the last one to boot, so he should be a key cog in New Orleans' relentless attack against the Falcons in Week 12, even with Alvin Kamara on hand to siphon around half of the team's backfield touches.
Ka'imi Fairbairn missed a pair of FGAs, but managed 11 points last week and leads the NFL with 27 FGA entering Week 12 when Houston squares off against a stingy Tennessee defense in Week 12.
Doug Baldwin has surpassed 52 yards once over the Seahawks' last four games, but he could have more success in Week 12 when Seattle takes on a Carolina defense that's given up at least 82 yards to five different WRs over their last five games.
Cam Newton went through an injury scare with his ankle last week but was able to come back in and throw for a season-high 357 yards, so the dual-threat quarterback should be deployed as usual when his Panthers host the Seahawks in Week 12.
T.Y. Hilton (155 yards, two TDs) destroyed Tennessee's one-on-one coverage last week, so Miami will have to decide if Xavier Henry or Minkah Fitzpatrick has the better skills to handle Indianapolis' No. 1 WR solo in Week 12.
Dalvin Cook found little room to run last week behind the Vikings struggling offensive line, but played a career-high 59 snaps and should bounce back in Week 12 against a Packers defense that ranks 26th against the run, allowing 126.1 yards per game.
Mitchell Trubisky has been held to one touchdown in two of his last three games for the Bears, but the lone deviation came two weeks ago against his Week 12 opponent in the Lions, a defense that has allowed three touchdown passes to three of their last four opponents.
Keke Coutee returned from injury last week to lead Houston with nine targets and 77 yards and will play a significant role Week 12 against Tennessee, which ranks 25th in YPG allowed to wide receivers.
Nick Mullens has thrown for at least 250 yards in each of his two starts with the 49ers and he has a fantastic Week 12 matchup against a Tampa Bay defense that's allowed the second-most points per game to opposing QBs.
Jacksonville's 21st-ranked offense didn't get deep downfield much last week, enabling three Josh Lambo field goals, and he could be productive again Week 12 against Buffalo, which allows 8.1 PPG to kickers (27th).
Stefon Diggs has at least 11 targets for the Vikings in four of his last five games, topping 100 yards and scoring in consecutive weeks entering a Week 12 clash against a Packers defense that allows just 223 yards per game through the air, but one that he posted a 9-128-2 line against earlier in the year.
Carson Wentz is coming off his worst game of the season for the Eagles but will face a Giants defense in Week 12 that he carved up in October for 278 yards and three scores.
Kenny Golladay saw 14 targets last week with the Lions missing multiple bodies across skill positions elsewhere, a trend that's likely to repeat itself in Week 12 against the Bears, a defense that just allowed 20 catches to Minnesota's duo of Stefon Diggs and Adam Thielen, and one which Golladay scored against just two weeks ago.
Nick Vannett has scored two TDs over the last three games, and he'll have a great Week 12 matchup when the Seahawks face the Panthers, who allow the most fantasy points per game to opposing TEs.
Tyler Boyd was targeted a lot last week but only managed to catch four of his 11 targets for 71 yards and with the potential of AJ Green's return, Boyd could see fewer targets but also easier coverage in Week 12 when the Bengals face a Browns' defense that gives up the third-most receiving yards per game.
James Conner had his second-worst fantasy performance last week, compiling less than 50 total yards, but in Week 12, he'll have a good chance to bounce back when the Steelers take on the Broncos, who give up the sixth-most rushing yards per game.
Baker Mayfield's last game was his most efficient game of his career, completing 17 of his 20 passes for 216 yards and three touchdowns, and in Week 12, he has a great chance for another good performance when the Browns take on the Bengals, who give up the most fantasy points per game to quarterbacks.
JuJu Smith-Schuster had his fifth game over 100 yards receiving last week when he caught eight of his 10 targets for 104 yards, and in Week 12, the Steelers face the Broncos, who give up the 12th-most receiving yards per game.
Jameis Winston is expected to start under center for Tampa Bay in Week 12 against the 49ers, as he once again has the keys to one of the league's most explosive passing offenses after replacing an ineffective Ryan Fitzpatrick last week.
Tre'Quan Smith delivered a 10-catch, 157-yard effort along with a touchdown last week, but the rookie wide receiver's week-to-week fluctuations in a Saints offense with a few high-profile mouths to feed keep him out of the automatic starter range despite a juicy Week 12 matchup with a Falcons team allowing 284.1 passing yards per game.
Marlon Mack has given the Colts' offense balance and is averaging 87.4 YPG while scoring five TDs over the last five weeks, numbers that are expected to swell Week 12 against Miami's 30th-ranked run defense.