George Kittle followed up his strong Week 1 performance with just 22 yards last week, but he'll have a fantastic matchup in Week 3 when the 49ers face a Chiefs defense that gave up 164 yards and a TD to the Steelers' tight ends last week.
Justin Tucker has been perfect so far this season going seven-for-seven in extra points and three-for-three in field goal attempts, including a 55-yarder last week, so with the Broncos in Week 3 you can expect another good kicking performance.
DeAndre Hopkins' production was enhanced by the return of Will Fuller last week, and that added threat will help in Week 3 against the Giants, who rank second in yards allowed to wideouts.
Julio Jones and the Falcons will play host to the division rival Saints in Week 3, which means he'll be going against a vulnerable secondary that got burned for 293 yards and three touchdowns by Tampa Bay's top two receivers in Week 1 then allowed 150 yards and a score to Cleveland's top two guys in Week 2.
Antonio Brown leads all receivers with the most targets this season with 33 through two games, and Brown now has a great matchup in Week 3 as the Steelers take on the Buccaneers, who have given up the second-most receiving yards this season.
Patrick Mahomes has thrown an incredible 10 touchdowns without an interception through his first two games as the Chiefs' new quarterback, and he's set up for another huge performance in Week 3 against a 49ers defense that's allowed nearly 300 passing yards per game.
JuJu Smith-Schuster had another big performance in Week 2, catching 13 of his 19 targets for 121 yards and a touchdown, which was his second-straight week over 100 yards, and in Week 3, the Steelers take on the Buccaneers, who have given up the second-most receiving yards this season.
Alvin Kamara has netted 240 scrimmage yards and three touchdowns through two weeks, so he's primed for another huge outing in the Saints' Week 3 clash with a Falcons team that just allowed pass-catching back Christian McCaffrey to rack up 102 yards on 14 receptions.
Zach Ertz led the Eagles in receiving in Week 2, and with Alshon Jeffery and Mike Wallace both out Week 3 and Carson Wentz back under center, the tight end has the chance to shine against a mediocre Colts passing defense allowing 249 passing yards per tilt.
Travis Kelce exploded for 109 yards and two touchdowns Sunday, and he should remain a huge part of a dangerous Chiefs passing game in Week 3 against a 49ers defense that's already allowed two TDs to opposing tight ends.
Jimmy Garoppolo is averaging 1.5 TDs per game, but he'll face a defense that's allowing an average of 438 yards and three TDs in the 49ers' Week 3 matchup with the Chiefs.
Nelson Agholor has double-digit targets in each of the Eagles' first two games, and with Alshon Jeffery and Mike Wallace both out for Week 3, he has the chance to explode with Carson Wentz back under center against a mediocre Colts passing defense allowing 249 passing yards per tilt.
Saquon Barkley had a franchise-best 14 catches for a New York Giants running back in Week 2, and he'll face a Houston Texas defense in Week 3 that has been mediocre in terms of both rushing and passing defense thus far in 2018.
Ezekiel Elliott has scored in each of the first two games for the Dallas Cowboys, as they have reverted back to a more run-based attack, which certainly favors Elliott as he faces a Seattle defense in Week 3 that looks like a shell of its former self.
Odell Beckham was bottled up in Week 2, but the Giants' No. 1 receiver will face a Houston Texans defense in Week 3 that's allowed five passing touchdowns in 2018, which is tied for 25th in the league.
Marquise Goodwin missed last week's game with a quad injury, but if he's able to return to the 49ers' lineup in Week 3, he'll have a fantastic matchup against a Chiefs defense that's given up an average of 438 passing yards per game.
Michael Thomas has been one of the league's best receivers heading into the Saints' Week 3 tilt with the Falcons, having already racked up 28 catches for 269 yards and three touchdowns.
Mike Evans heads into the Buccaneers' Week 3 home tilt against the Steelers having already accrued 230 yards and two touchdowns on 17 catches through two games.
Robbie Gould has kicked multiple field goals in each game to start the season, and he should continue to be busy in a potential shootout when the 49ers take on the Chiefs in Week 3.
Tyreek Hill scored his fourth touchdown of the season in Sunday's win, and his immediate chemistry with new Chiefs quarterback Patrick Mahomes makes him an elite option at wide receiver for Week 3's matchup against a 49ers defense that's allowed nearly 300 passing yards per game.
Ben Roethlisberger has thrown for the second-most passing yards (787 yards) in the NFL through two games, and in Week 3, the Steelers face the Buccaneers, who have given up the second-most fantasy points to quarterbacks this season.
Indianapolis' short passing attack (5.8 YPA) paid off in a win last week, and Andrew Luck will continue to spread the targets in Week 3 against the Eagles' 28th-ranked pass defense (309.0 YPG).
Dan Bailey will make his Vikings debut in Week 3 against Buffalo, and he should see a plethora of opportunities against a defense that ranks last in points allowed, surrendering 39.0 per game through two weeks.
T.Y. Hilton's thriving in Indianapolis' short-passing attack, catching TDs in each of the first two weeks heading into Week 3 against the Eagles, who rank 30th in yards allowed to wideouts.
Lamar Miller has not found the end zone, but is averaging 4.9 YPA, as Houston leads the NFL in rushing heading into Week 3 against the Giants' 29th-ranked rushing defense (137.5 ypg).
Kirk Cousins is averaging 335 yards and three touchdowns through two games in his new surroundings, and while he faces a Buffalo defense in Week 3 that has allowed six touchdown passes, the Vikings could look to find more balance in their offense in a game that could turn one-sided early.
Chris Hogan caught a pair of touchdowns against the Jaguars, but his relative paucity of receptions thus far could make him a sneaky great play against the Lions' leaky defense in Week 3.
Cam Newton has one game with under 200 passing yards and one with over 300 thus far this season, but he's likely to come closer to the latter while still contributing on the ground in Week 3 as the Panthers take on a Bengals defense that just got burned for 376 yards through the air by Joe Flacco.
Matthew Stafford has thrown 99 passes in two weeks as a poor run game and defense have forced the Lions to play catch up, a trend that seems likely to continue in Week 3 against a Patriots defense that allowed 268 yards and surrendered four touchdown passes to Jacksonville's Blake Bortles.
Pierre Garcon is averaging just five targets per game, but he'll have an excellent matchup when the 49ers play a Chiefs defense in Week 3 that's allowing 438 passing yards per contest.
Michael Crabtree has the most targets so far this season for the Ravens and he'll hope to continue to be the top target for Joe Flacco in Week 3 when they take on the Broncos, who have given up 293 receiving yards per game.
Kareem Hunt piled up 80 yards from scrimmage Sunday, including his first touchdown of the season, but he may need to take advantage of his opportunities as a receiver in Week 3, as the Chiefs face a 49ers defense that has yet to allow a rushing TD in 2018.
Golden Tate has seen a massive 28 targets through two weeks with Detroit having attempted 105 passes, and Week 3's matchup against a Patriots team that seems likely to grab an early lead should have that volume remaining constant Sunday night against a secondary that is allowing 268 yards per game.
Rob Gronkowski was held in check against the Jaguars (15 yards), but should be back to his role as an elite option against the Lions in Week 3, despite the fact that they've held opposing tight ends in check thus far.
Randy Bullock has been perfect so far this season going eight-for-eight in extra points and hitting all four of his field goal attempts, and with the Bengals scoring the fourth-most points per game this season, expect Bullock to have another good fantasy game against the Panthers in Week 3.
Keelan Cole has averaged 99.3 ypg over the last six games, emerging as the Jaguars' No. 1 wideout heading into Week 3 against the Titans, who rank 31st in yards allowed to wideouts.
Chandler Catanzaro's Buccaneers have scored 75 points through two weeks, and he should see plenty more opportunities in Week 3 when they host a Steelers team that's allowed 63 points in two weeks.
James White has 11 receptions (against just nine carries) through two games, which separates him from the Patriots' other backs, and he gets a great matchup against the Lions, who allowed seven receptions to the 49ers backs last week.
Tevin Coleman topped 100 rushing yards as the Week 2 starter with Devonta Freeman sidelined due to a knee injury, and he should serve as Atlanta's primary running back against the Saints in Week 3 with Freeman still out.
Stefon Diggs has scored three times in two weeks and eight times in the Vikings' last five games dating back to last season entering Week 3's matchup against a Bills secondary that has already allowed six touchdown passes through two games.
Sony Michel didn't do much in his Patriots debut (10 carries for 34 yards), but should see more room to run against the Lions porous defense in Week 3, who allowed 190 rushing yards to the 49ers last week.
Jarvis Landry didn't have the monster game owners were looking for last week, but continued to be a large part of the Browns passing attack, catching five of his seven targets for 69 yards, and in Week 3, he has a good matchup against the Jets' defense who have given up the seventh-most fantasy points to receivers.
Tom Brady was reduced to a game manager for the Patriots against the Jaguars, but he should have a much easier time against the Lions in Week 3, who have allowed 78 points through the first two weeks.
Adam Thielen has topped 100 yards in consecutive weeks while garnering 25 targets, and the only thing that could slow him down in Week 3 against a Buffalo defense that allows 258 yards per game could be game flow, with the Vikings likely to take a comfortable lead early.
Kenyan Drake has seven receptions on the season, and coupled with out-carrying Frank Gore two-to-one, he should find room to run against the Raiders in Week 3, who allowed Phillip Lindsay to run for 107 yards on just 14 carries last week.
Sammy Watkins is coming off his first 100-yard game as a Chief, and he seems poised for another big performance in Week 3 against a 49ers defense that's allowed nearly 300 passing yards per game.
Matt Bryant has converted all three of his field-goal attempts through the Falcons' first two games heading into a Week 3 home tilt against the Saints.
Will Fuller rekindled chemistry with QB Deshaun Watson quickly in his season debut last week, but Houston faces the Giants' second-ranked pass defense in Week 3.
DeSean Jackson has been known as a boom-or-bust performer throughout his career, but he's boomed to the tune of 275 yards and three touchdowns through two weeks ahead of the Buccaneers' Week 3 clash with a Steelers team that's already allowed seven touchdowns through the air.
Jordan Reed has 13 targets for over 100 yards and a touchdown through Washington's first two games, and he'll clash with a Green Bay defense in Week 3 allowing 284 passing yards per tilt thus far in 2018, which is 24th in the NFL.