Dalvin Cook has seen at least 24 touches in four straight games and has 13 rushing scores through nine outings, and should again be busy and successful for the Vikings in Week 12 against a Panthers defense allowing 4.6 yards per carry and 14 rushing scores to date.
Duke Johnson should see the majority of Houston's backfield touches for a fourth consecutive game with David Johnson (concussion) sidelined, and a Week 12 date with a Lions defense that has allowed league highs in both rushing touchdowns (14) and receiving touchdowns (five) to running backs should help get the struggling Texans tailback back on track.
KhaDarel Hodge caught three passes for the first time all season for the Browns his last time out, and in Week 12, he gets a Jaguars defense allowing 185.5 yards per game to his position, the sixth-highest total in the league.
Jarvis Landry has not gained 30 yards over either of his past two outings for the Browns, but in Week 12, he gets a Jaguars defense allowing 185.5 yards per game to his position, the sixth-highest total in the league.
Rashard Higgins has six catches for 113 yards over his past two outings for the Browns, and in Week 12, he gets a Jaguars defense allowing 185.5 yards per game to his position, the sixth-highest total in the league.
Justin Jefferson continues to make big plays for the Vikings, averaging at least 16.9 yards per catch in each of his past three games, and could see a huge uptick in targets in Week 12 against a decent Panthers pass defense that's allowing 6.9 yards per attempt if Adam Thielen (Covid) is forced to sit.
Antonio Gibson has scored in four-straight games for Washington and will face a lackluster Cowboys run defense in Week 12 yielding 153.8 yards per contest on the ground, which is 31st in the NFL.
Latavius Murray and the Saints have a solid Week 12 matchup against a Broncos defense that has allowed the sixth-most fantasy points to running backs per game (21.6) since Week 6.
Brandin Cooks has 496 receiving yards in his last six games, and he should continue to play a prominent role in Houston's passing attack in Week 12 against a Lions secondary that has allowed the fifth-most yards to wide receivers this season (1,855).
Tyreek Hill has posted back-to-back 100-yard performances and has scored in every game but one this season, and the Kansas City speedster figures to be dangerous again in Week 12 against a Buccaneers defense that had trouble containing Cooper Kupp and Robert Woods on Monday night.
Terry McLaurin is fourth in the NFL in receiving yardage for the Washington Football Team and will face a suspect Dallas pass defense in Week 12 allowing 232.6 passing yards per contest, which is 14th in the league.
David Montgomery (concussion) appears to be trending towards a Week 12 return for the Bears, and while he's been plodding for the majority of the year, volume has always been steady and should continue against Green Bay, both because Chicago has questions under center and because the Packers are allowing 4.4 yards per carry, and four opposing rushers have gone for 90+ yards against them in the last six weeks.
Davante Adams has scored in five straight, catching at least seven balls in each game during that stretch, and that steady volume should allow him to lead the Packers again in Week 12 against a Bears defense that's allowed only five touchdown catches to opposing receivers, but three in the last two weeks, with two receivers topping 100 yards in that stretch.
Cooper Kupp has posted at least 40 yards in all but one of the Rams' games this season, and he'll have potential for upside in a Week 12 matchup against a 49ers defense that's allowed the 12th-most fantasy points to WRs.
Alvin Kamara and the Saints have a solid Week 12 matchup against a Broncos defense that has allowed the sixth-most fantasy points to running backs per game (21.6) since Week 6.
DeVante Parker hauled in a fantastic touchdown grab as he's shown himself to be a dependable performer week-in, week-out for the Dolphins heading into a matchup with the Jets, who boast one of the worst and youngest secondaries in the NFL.
Keenan Allen posted a season-high 16 catches for 145 yards last week, and his typically sky-high target volume gives him a very high floor heading into the Chargers' Week 12 road clash with a Bills defense that ranks 17th in passing yards per game allowed.
Stefon Diggs narrowly missed out on his fifth 100-yard game of the season for the Bills just prior to the bye week and is in line to break the 1,000-yard marker for the season heading into Week 12 against the Chargers, who showed some cracks in their coverage over the top last week against the Jets.
Michael Pittman is starting to come into his own with 167 receiving yards a touchdown over the past two weeks, and the Colts' rookie second-round pick will look to build on his recent momentum in Week 12 against a Titans defense that's allowing 267.4 passing yards per game.
Will Fuller already has a career-high 708 receiving yards, as he and Brandin Cooks are the clear-cut top two receiving options for the Texans heading into a Week 12 matchup with a Lions defense that has allowed 1,855 yards to wide receivers -- fifth-most in the league.
Kerryon Johnson played 70 percent of the snaps for the Lions last week in D'Andre Swift's absence, and while that turned into only eight touches, he looks like the preferred option for the Lions in Week 12 on Thursday should Swift sit again, and facing a Texans defense that allows 5.1 yards per carry, he may not need many touches to produce.
Robert Woods has scored a TD in four of the Rams' last six games, and he'll have a favorable Week 12 matchup against a 49ers defense that's allowed the 12th-most fantasy points to WRs.
Jakeem Grant saw six targets, tied for second-most on the Dolphins, but mustered just 12 yards heading into a much better matchup in Week 12 against the Jets and their bottom-five secondary.
Jalen Reagor has amassed eight catches for 99 yards over his last two contests for Philadelphia and has the chance for a breakout performance in Week 12 versus a lackluster Seattle secondary allowing the most passing yards per game in the NFL this season.
Adrian Peterson saw only seven carries in D'Andre Swift's absence last week, his fourth straight game with eight carries or less, suggesting he won't see enough touches for the Lions in Week 12 on Thursday to take advantage of a soft Texans run defense that allows 5.1 yards per carry.
Denzel Mims saw a team-high eight targets but his boom-or-bust routes led to just three receptions as he's quickly grown into a crucial option in the Jets passing game heading into Week 12 against the Dolphins and their bottom-10 fantasy secondary.
Tim Patrick is coming off his third 100-yard performance of the season, but the Broncos wideout could have trouble repeating those numbers in Week 12 against a Saints secondary that ranks 11th in passing yards per game allowed.
Breshad Perriman hauled in a 49-yard touchdown pass as his blistering speed and Joe Flacco's arm-strength could be a perfect pairing for the Jets heading into Week 12 against the Dolphins and their bottom-10 secondary.
Zack Moss seems to be the 1a in the Bills backfield heading into a positive matchup against the Chargers in Week 12, who have allowed seven rushing touchdowns in their last five games.
Nelson Agholor scored his sixth touchdown of the season last week, and the Raiders' top wideout figures to pad his totals further in Week 12 on the road against a Falcons defense that ranks second-last in the league in passing yards per game allowed and passing TDs allowed.
Zach Pascal has racked up at least 54 receiving yards in four of his last seven games but hasn't surpassed 58, as his ceiling continues to be capped in a Colts offense that likes to spread the ball around heading into a Week 12 matchup with the Titans.
James Conner has been held under 50 yards on the ground in three of his past four games -- including once by the Ravens -- but heading into Week 12, Baltimore ranks in the middle of the pack allowing 90.8 rushing yards per game to his position.
Damiere Byrd did an excellent job of asserting himself in the Patriots offense, breaking the 100-yard threshold and catching a touchdown while having other opportunities where he was wide open heading into another positive matchup against the Cardinals in Week 12 if he doesn't draw Patrick Peterson.
Mike Williams has posted a solid 16-290-2 line on 27 targets over the last four games, and the Chargers' No. 2 wideout could be productive again in Week 12 against a Bills defense that ranks 17th in passing yards per game allowed.
Robby Anderson and the Panthers have an interesting Week 12 matchup against a Vikings defense that allowed the fourth-most yards per pass attempt (9.8) over the first six games of the year but the third-fewest (6.90) since.
CeeDee Lamb has found the end zone in consecutive games for the Cowboys but will face a Washington defense in Week 12 that's allowed 15 passing scores in 2020, which is tied for eighth in the league.
Jerry Jeudy has seen at least eight targets in four straight games, but the Broncos rookie may have trouble turning that volume into production in Week 12 against a Saints secondary that ranks 11th in passing yards per game allowed.
Tee Higgins has seen 28 targets over his past three outings for the Bengals, and in Week 12, he gets a Giants defense allowing 172.3 receiving yards per game to his position, the 13th-highest total in the league.
Jonathan Taylor reclaimed his spot atop the Colts' running back depth chart with 114 scrimmage yards on 26 touches last week, and the rookie will look to build off that momentum in Week 12 against a Titans defense that held him to a career-low 12 rushing yards in their first meeting.
Corey Davis is coming off his third 100-yard performance of the season and led the Titans with 67 receiving yards in their first meeting with the Colts, so he'll look for an even stronger performance in the Week 12 rematch between AFC South foes.
Curtis Samuel and the Panthers have an interesting Week 12 matchup against a Vikings defense that allowed the fourth-most yards per pass attempt (9.8) over the first six games of the year but the third-fewest (6.90) since.
Brian Hill and the Falcons have a Week 12 matchup against a Raiders defense that has allowed just 3.9 yards per rush (13th) with five rushing touchdowns (22nd) over its past five games.
Kareem Hunt has failed to top 70 yards or score just once all season for the Browns, and in Week 12, he gets a Jaguars defense allowing 97.3 yards on the ground per game to his position, the 13th-highest total in the league.
Possibly without Julio Jones (hamstring) next to him, Calvin Ridley and the Falcons have a Week 12 matchup with a Raiders defense that is 13th in total touchdown passes allowed (16) and 18th in yards allowed per pass attempt (7.3) through 10 games in 2020.
Josh Reynolds had averaged nine targets in the Rams' last three games prior to last week, but he could get back on track in a Week 12 matchup against a 49ers defense that's allowed the 12th-most fantasy points to WRs.
Amari Cooper did have seven catches for 80 yards when Dallas played Week 12 opponent Washington last month, though Washington is allowing the fewest passing yards per game in the NFL this season, and Cooper has not scored a touchdown in over a month.
Adam Thielen has scored four times over the last two weeks, and 11 times on the year, and would have a great chance to add to those numbers for the Vikings in Week 12 against a Panthers secondary that's allowed 16 TD passes to date, but will need to be removed from the Reserve/Covid-19 list before suiting up.
Wayne Gallman has five touchdowns in his last four games for the Giants but will face a Bengels defense in Week 12 that's surrendered just eight rushing scores in 2020, which is tied for eighth in the NFL.
DJ Moore and the Panthers have an interesting Week 12 matchup against a Vikings defense that allowed the fourth-most yards per pass attempt (9.8) over the first six games of the year but the third-fewest (6.90) since.
James Robinson has racked up at least 90 scrimmage yards in eight of his first 10 games, and the standout Jaguars rookie should continue to churn out yardage in Week 12 against a Browns defense that's allowing 105.0 rushing yards per game.