Darren Waller caught his fourth touchdown of the season last week, and Derek Carr's favorite target could be headed for a huge performance in Week 12 as the Raiders face a Falcons defense that ranks in the bottom four in catches, yards and TDs allowed to tight ends.
Travis Kelce is coming off his fourth 100-yard performance of the season, and he figures to get plenty of volume in Week 12 as Kansas City faces a Buccaneers defense that's tied for 25th in the league in receptions allowed to tight ends.
Austin Hooper has just four catches for 44 total yards over his past two outings for the Browns, but in Week 12, he gets a Jaguars defense allowing 55.7 yards per game to tight ends, the seventh-highest total in the league.
Tyler Eifert has just one touchdown this season and is yet to break 50 yards in a Jaguars uniform, but perhaps he can turn things around in Week 12 against a Browns defense that has allowed the fifth-most yards (583) and fourth-most touchdowns (seven) to tight ends.
Dawson Knox saw four targets but couldn't really make much out of it heading into the Bills bye week prior to their Week 12 matchup with the Chargers, who have allowed eight touchdowns to opposing tight ends this season including TDs in four-consecutive games.
Mike Gesicki did an excellent job working as a strong second option in the Dolphins passing game heading into Week 12 against the Jets, who have allowed five touchdowns to opposing tight ends in the last five games.
Dallas Goedert led the Eagles in receiving last game while also finding the end zone, though the possible return of Zach Ertz to the lineup could stunt his progress, even in Week 12 versus a Seattle defense allowing a staggering 343.7 passing yards per outing.
Jared Cook and the Saints have a Week 12 matchup against a Broncos defense that has allowed the 12th-most receptions to tight ends (51) in 2020.
Jordan Reed posted 62 yards in the 49ers' last game, and he could be a focal point of the passing attack in Week 12 against a Rams defense that's been a middling unit in terms of fantasy production allowed to TEs this season.
Hunter Henry has caught multiple passes in every game this season and scored in two straight weeks, and his steady volume could result in big numbers during the Chargers' Week 12 road clash with a Bills defense that's surrendered the most receiving yards in the league to tight ends.
Ian Thomas and the Panthers have an interesting Week 12 matchup against a Vikings defense that allowed the fourth-most yards per pass attempt (9.8) over the first six games of the year but the third-fewest (6.90) since.
Chris Herndon hauled in a touchdown, his first of a woebegone season for the Jets, heading into Week 12 against the Dolphins who have allowed three touchdowns to opposing tight ends in their last three games.
Will Dissly could be in line for an increase in targets for the Seahawks after Greg Olsen (foot) landed on IR, and he could be set up for solid production in a Week 12 matchup against an Eagles defense that's allowed the fifth-most fantasy points to tight ends.
Eric Ebron has drawn a red-zone target in each of the last six games for the Steelers, and in Week 12, he gets a Ravens defense that has allowed five touchdowns to tight ends this season, three off the league lead.
Possibly helping fill in for Julio Jones (hamstring), Hayden Hurst and the Falcons have a Week 12 matchup with a Raiders defense that is 13th in total touchdown passes allowed (16) and 18th in yards allowed per pass attempt (7.3) through 10 games in 2020.
Jonnu Smith has seven receiving touchdowns and scored on the ground in the first meeting against the Colts, and the Titans tight end will look to get back into the end zone in the Week 12 rematch against a defense that has allowed only one receiving touchdown to his position this season.
Jack Doyle scored a touchdown in his return from a concussion last week, but he'll remain touchdown-dependent against the Titans in Week 12 with Trey Burton and Mo Alie-Cox both on hand to siphon off tight end snaps for the Colts.
Noah Fant topped 50 receiving yards last week for the first time since Week 2, and his improving health makes him an interesting sleeper in Week 12 as the Broncos host a Saints defense that's given up six TDs through 10 games to tight ends this season.
Logan Thomas has been held out of the end zone for Washington in three straight contests, but has a great chance at a return engagement to the promised land versus a Dallas defense in Week 12 that's given up the most passing scores this season.
Robert Tonyan fount the end zone last week for the first time since Week 4, but has seen only 10 targets over the Packers last three games, giving him a volatile outlook in a Week 12 matchup against a Bears defense that hasn't allowed more than 65 yards to any opposing tight end to date.
Ryan Izzo caught the Patriots' final heave at the end of the game to add a 50-yard reception for gloss on an otherwise quiet day heading into Week 12 against the Cardinals, who haven't allowed a touchdown to an opposing tight end in their last six games.
Evan Engram has gone over the 50-yard receiving mark just twice in 2020 for the Giants, but will face a suspect Bengals defense in Week 12 allowing 254.7 passing yards per tilt, which is 23rd in the NFL.
Dalton Schultz has 21 targets over the last three games for Dallas and found the end zone in his last outing, but will face a Washington defense in Week 12 allowing the fewest passing yards per game this season.
Jordan Akins broke out with a season-high 83 yards last week, but replicating that effort won't be easy for Houston's top tight end in Week 12 against a Lions defense that has allowed the second-fewest yards in the league to tight ends (344) while struggling to defend other positions.
Jimmy Graham has topped 34 yards only twice all season, and figures to be a touchdown dependent option for the Bears in Week 12 against the Packers, a defense that allowed two tight ends to score last week, but only one all season prior, with four topping 50 yards.
Trey Burton scored his fourth touchdown of the season last week but will compete with Jack Doyle and Mo Alie-Cox for snaps in a crowded Colts tight end room against the Titans in Week 12.
Rob Gronkowski and the Buccaneers have a tough Week 12 matchup against a Chiefs defense that has allowed the fourth-fewest yards per pass attempt (6.18) and the seventh-fewest passing touchdowns (7) since Week 6.
Mo Alie-Cox has been pushed back down to third on Indianapolis' tight end depth chart with both Trey Burton and Jack Doyle expected to be healthy for the team's Week 12 matchup with the Titans.
Drew Sample hasn't scored for the Bengals all year, and in Week 12, he gets a Giants defense that has allowed just two touchdowns to tight ends this season.
T.J. Hockenson has scored just one in his last four outings after four of his first six for the Lions, but with Detroit having a depleted receiving corps, he should again flirt with 5+ targets Thursday in Week 12 against a Houston defense that's allowed two opposing scores to this position since Week 5, assuming he plays through a shoulder issue.
Tyler Higbee continues to split TE targets with Rams' teammate Gerald Everett, lowering his potential upside in Week 12 against a 49ers defense that's allowed the fewest fantasy points to TEs this season.
Gerald Everett is splitting targets with Rams' teammate Tyler Higbee, lowering his potential upside in Week 12 against a 49ers defense that's allowed the fewest fantasy points to TEs this season.
Darren Fells has been eclipsed by Jordan Akins as Houston's top tight end with Akins healthy, and both guys could find sledding tough in Week 12 against a Lions defense that has limited the position to 344 yards -- second-fewest in the league.
Mark Andrews has 12 catches for 157 yards and a score over his past two games for the Ravens, but in Week 12, he gets a Steelers defense that has allowed just one touchdown to a tight end all season.
Dan Arnold has averaged 2.5 targets over Arizona's last four games, and he won't be a recommended fantasy option in Week 12 against a New England defense that's allowed the fifth-fewest fantasy points to TEs this season.