Kareem Hunt was kept from the end zone for the first time since Week 1 his last time out for the Browns, but in Week 7, he gets a Bengals defense allowing 119.3 rushing yards per game, the fifth-highest total in the league.
Chris Carson has posted at least 66 combined yards in each of the Seahawks' five games, and he'll have an excellent Week 7 matchup against an Arizona defense that's among the 10 most favorable defenses to opposing running backs.
Boston Scott amassed 264 yards and four touchdowns in two games versus the New York Giants last season, and with Miles Sanders likely sidelined for Week 7 versus the Giants, Scott has the chance for volume touches as the starter out of the backfield for the Eagles.
David Johnson has at least 18 touches in each of Houston's last three games, and his role as a three-down workhorse gives Johnson a high Week 7 floor against a Packers defense that just allowed 113 rushing yards and two touchdowns to Tampa Bay's Ronald Jones.
Devonta Freeman has rushed at least 17 times for at least 60 yards in each of the last two games for the Giants, and will face a surprisingly lackluster Eagles rushing defense in Week 7 that's tied for the most rushing touchdowns allowed in the NFL this season.
James Robinson has at least 16 touches in each of Jacksonville's first six games and four touchdowns heading into a Week 7 meeting with a Chargers defense that has been lit up for 68 points in its last two games.
Raheem Mostert will miss the 49ers' Week 7 game against the Patriots with an ankle injury.
D'Ernest Johnson got just four carries his last time out for the Browns, but in Week 7, he gets a Bengals defense allowing 119.3 rushing yards per game, the fifth-highest total in the league.
Henry's coming off three consecutive games with multiple rushing touchdowns and just produced 264 scrimmage yards in last week's win, so even a Week 7 date with a Steelers defense that's allowing just 66.2 rushing yards per game is unlikely to slow down Tennessee's superstar running back.
Frank Gore was once again bottled up for the Jets against the Dolphins but will continue to see plenty of work with just the veteran and the rookie La'Mical Perine in the backfield heading into Week 7 against the Bills, who allowed five rushing touchdowns in their first five games.
Malcolm Brown had a season-low five touches last week, and he could struggle to get back on track in Week 7 when the Rams face a Bears defense that allows fewer than 100 rushing yards per contest.
James White saw a team-high nine targets, leading the Patriots in receptions and yards against the Broncos as Cam Newton was continuously under-duress heading into Week 7 against the 49ers, who have done an excellent job against the run, allowing the third-fewest fantasy points per game to opposing running backs through the first five weeks.
La'Mical Perine saw seven carries in the first game of the post-Le'Veon Bell-era, but managed less than four yards per carry heading into Week 7 against the Bills, who bottled up the Jets run game in their first matchup of the season, holding them to 3.3 yards per carry.
Zack Moss made his return to the field against the Chiefs, but managed just 10 yards on the ground and the Bills face another tough run defense in the Jets in Week 7, who held him to 11 yards on nine carries in the opener.
Kenyan Drake hasn't posted a 100-yard game this season, but he's scored in each of his last two contests, and he may struggle to extend his scoring streak in Week 7 when the Cardinals face a Seattle defense that's allowed the ninth-fewest fantasy points to running backs.
Antonio Gibson has collected fewer than 60 scrimmage yards in each of the last two games while failing to find the end zone, and Washington's running-back-by committee scheme is likely to continue in Week 7, though Washington faces against a Cowboys defense allowing just 155.8 yards per game on the ground, which is 30th in the NFL.
Carlos Hyde (shoulder) missed each of Seattle's last two games, but he's yet to surpass 37 total yards in any game this season, making him a weak fantasy option despite an excellent Week 7 matchup against an Arizona defense that's among the 10 most favorable defenses to opposing running backs.
J.D. McKissic has at least 37 receiving yards in four-straight games for Washington but has not scored a touchdown this season and will continue to share touches out of the backfield with Antonio Gibson in Week 7 versus the Dallas Cowboys.
Joe Mixon suffered a foot injury his last time out for the Bengals, and even if he can suit up in Week 7, he'll get a Browns defense allowing just 73.8 yards on the ground per game to running backs, the sixth-lowest total in the league.
Damien Harris struggled to get much of anything going on the ground against the Broncos, running for just three yards per carry heading into the Patriots Week 7 clash with the 49ers, who have yet to allow a 100-yard rusher through their first five games.
Devin Singletary, along with the rest of the Bills offense, struggled to get anything going against the Chiefs and faces a stout Jets run defense in Week 7 that held him to just 30 yards rushing in the opener.
Darrell Henderson has averaged 16 touches over the Rams' last two games, but he'll have a tough week 7 matchup against a Bears defense that allows fewer than 100 rushing yards per contest.
Chase Edmonds continues to produce despite averaging fewer than eight touches per game, and he may need increased volume to continue his production in Week 7 when the Cardinals face a Seattle defense that's allowed the ninth-fewest fantasy points to running backs.
Jerick McKinnon has seen a drastic decrease in touches over the 49ers' last two games, but if Raheem Mostert (ankle) misses the game, he could see enough volume to help fantasy in managers in Week 7 despite a difficult Week 7 matchup against a Patriots defense that's allowed the sixth-fewest fantasy points per game to opposing running backs.
Cam Akers didn't receive a single touch last week, as he appears to be third on the Rams' depth chart at running back, making him a risky fantasy option in Week 7 against a Bears defense that allows fewer than 100 rushing yards per contest.
Giovani Bernard has totaled more than 35 yards in a game just once all season for the Bengals, and even if Joe Mixon misses Week 7 with a foot injury, Bernard gets a Browns defense allowing just 73.8 yards on the ground per game to running backs, the sixth-lowest total in the league.
Jeremy McNichols racked up 62 scrimmage yards on seven touches last week, but his limited involvement behind workhorse Derrick Henry in Tennessee's backfield will make it tough for McNichols to carve out value against the vaunted Steelers defense in Week 7.
Rex Burkhead took a backseat to James White in the Patriots passing game, seeing no targets to White's nine heading into Week 7 against the 49ers, who have done well to cover running backs in the passing game, allowing just one touchdown in their first five games.
Miles Sanders injured his knee last game for the Eagles and is unlikely to take the field against the New York Giants in Week 7.
Wayne Gallman has become nonexistent with the signing of Devonta Freeman, leaving him a poor option for the Giants even against an Eagles defense in Week 7 allowing 125.5 rushing yards per game, which is 22nd in the NFL.
Chris Thompson's niche as a receiving back isn't earning him much volume since starter James Robinson has also shown to be an adept pass-catcher out of the Jacksonville backfield, so Thompson has topped 40 scrimmage yards just once heading into a Week 7 road game against the Chargers.
Duke Johnson has broken 20 scrimmage yards only once this season and should remain an afterthought in Houston's offense against the Packers in Week 7 and beyond, as long as bell cow David Johnson stays healthy.