Josh Allen has thrown for at least two touchdowns in all but four outings this season for the Bills, and in Week 18, he gets a Jets defense that ranks last in DVOA so far in 2021.
Ben Roethlisberger has not thrown for 160 yards over any of his last three games for the Steelers, but in Week 18, he gets a Ravens defense that ranks 30th in pass DVOA so far in 2021.
Justin Herbert has thrown multiple TDs in six of the last seven games, and he'll need to be productive again in Week 18 with a wild-card spot on the line as the Chargers take on a Raiders defense that ranks 10th in passing yards per game allowed.
Aaron Rodgers indicates he'll start for the Packers in Week 18 despite the team already locking up the No. 1 seed, and while it's an inviting matchup against a Lions team allowing 8.0 yards per attempt and one he lit up for four touchdowns previously, it remains possible he'll have to do his damage in far less than four quarters.
Taysom Hill has failed to reach the end zone multiple times in each of his last two games heading into a Week 18 matchup against an Atlanta defense that has allowed 32 total touchdowns to opposing quarterbacks this season.
Case Keenum threw for 199 yards and a touchdown in his lone start this year for the Browns, and in Week 18, he gets a Bengals defense that ranks 24th in pass DVOA so far in 2021.
Matthew Stafford has a 5:6 TD:INT ratio over the Rams' last three games, but he should have a strong scoring floor in a Week 18 matchup against a 49ers defense that's allowed 1.6 TD passes per game and the 16th-most fantasy points to opposing QBs over the last five weeks.
Justin Fields is hoping to return from a two-week absence due to an ankle injury for the Bears in Week 18, where he'd face a Vikings defense that he posted 320 total yards against last time out, and one that allows 252.1 yards per game and 7.5 yards per attempt.
Russell Wilson has been held to fewer than 240 passing yards in four of Seattle's last five games, but he's thrown multiple touchdown passes in four of his last five games, so he should have a reasonable scoring floor in a Week 18 matchup against a Cardinals defense that's allowed 2.5 passing TDs per game and the seventh-most fantasy points to opposing QBs over the last five weeks.
Carson Wentz has an efficient 26:6 TD:INT in his first season with the Colts, but he has thrown for more than 180 yards only twice in his last seven starts, and the team will likely move the ball primarily on the ground in Week 18 against the 2-14 Jaguars.
Taylor Heinicke has thrown multiple touchdown passes just twice in the last 11 games for Washington but will face a reeling Giants defense in Week 18 that's surrendered nine passing scores during its current five-game losing streak.
Kirk Cousins will need to clear league health protocols if he's to suit up for the Vikings in a meaningless regular season finale against a Bears' defense that's vulnerable to the pass, allowing 7.4 yards per attempt and a 28:8 TD:INT ratio, but one that held him to just 87 yards in an earlier meeting.
Jared Goff remains uncertain to start for the Lions in Week 18 due to a knee injury, but should he gain clearance, he'll face a Green Bay defense that's allowed multiple touchdown passes in five of their last six games, and could rest starters at some point with the No. 1 seed already clinched.
Ryan Tannehill has topped out at 209 passing yards in his past five games and carries a pedestrian 17:14 TD:INT into the Week 18 regular-season finale against the Texans, but despite the quarterback's mediocre play, the Titans can secure the top seed in the AFC with a win.
Jalen Hurts failed to find the end zone last game for the Eagles and it remains to be seen how much he will play in Week 18 versus the Cowboys as both teams have locked up playoff spots and can only maneuver slightly in terms of seeding; if Hurts plays the majority of the contest, he will face a Dallas defense allowing 242.7 passing yards per tilt, which is 24th in the NFL.
Andy Dalton managed only 4.9 yards per attempt in last week's start, but if Justin Fields (ankle) is unable to play for the Bears in Week 18, Dalton would be in a favorable spot against a Vikings defense that allows 7.5 yards per attempt and 28 TD passes to date.
Derek Carr has thrown one touchdown or fewer in seven straight games, giving him a limited ceiling in Week 18 with a wild-card spot on the line as the Raiders face a Chargers defense that held him under 200 passing yards in their first meeting, the only team to do so this season.
Patrick Mahomes has a sharp 10:1 TD:INT over the last four games, but he faces a tough challenge in Week 18 as Kansas City takes on a Broncos defense that held him below 200 passing yards and without a TD in their first meeting, the only defense this season to accomplish that feat.
Kyler Murray has thrown just four touchdown passes over Arizona's last four games, and he'll look to get back on track despite a Week 18 matchup against a Seattle defense that's allowed 1.4 TD passes and the 13th-fewest fantasy points to opposing QBs over the last five weeks.
Davis Mills has topped 300 passing yards three times in an up-and-down rookie season for the Texans, and he'll be motivated to close out the season on a high note and make his case for the starting job next season in Week 18 against a Titans defense that has allowed 21 passing touchdowns but also notched 16 interceptions.
Lamar Jackson has thrown for at least 235 passing yards in all but two of his healthy games this year for the Ravens, and in Week 18, he gets a Steelers defense that ranks 15th in DVOA so far in 2021.
Gardner Minshew could see the field in Week 18 for the Eagles versus the Cowboys, as both teams have already clinched playoff berths and can only slightly change their seeding; if Minshew sees action, he will face an opportunistic yet beatable Cowboys pass defense allowing 242.7 passing yards per tilt, which is 24th in the NFL.
Drew Lock picked up a shoulder injury last week but is expected to play through it in Week 18 with Teddy Bridgewater still in the concussion protocols, giving him some modest upside as the Broncos take on a Kansas City defense that ranks 28th in passing yards per game allowed.
Tim Boyle could be in line to start for the Lions again in Week 18 with Jared Goff (knee) uncertain, where he'd take aim at a decent Packers secondary that's allowing just 6.5 yards per pass attempt, but 28 touchdown passes, the third-highest total in the league.
Sean Mannion was a game manager at best in a spot start for the Vikings, averaging 5.3 yards per attempt, but could again be called into duty in Week 18 if Kirk Cousins doesn't clear health protocols, or is rested by choice, in a Week 18 matchup against a Bears' defense that's held four of five quarterbacks under 188 yards, but surrendered 12 TD passes in that stretch.
Joe Burrow has thrown for 971 yards and eight touchdowns over his last two outings for the Bengals, and in Week 18, he gets a Browns defense that ranks 11th in pass DVOA so far in 2021.
Jimmy Garoppolo (thumb) will try to return from injury after missing the 49ers' last game, but after throwing just one touchdown pass in each of his last two games, he could have limited upside in a Week 18 matchup against a Rams defense that's given up 0.6 TD passes and the 11th-fewest fantasy points per game to opposing QBs over the last five weeks.
Dak Prescott has accumulated seven touchdown passes in his last two games for Dallas but will face an Eagles defense in Week 18 that's surrendered just 23 passing scores in 2021, which is tied for 11th in the NFL, and it remains to be seen how much Prescott will play with the Cowboys given that they cannot maneuver much in terms of playoff seeding.
Tom Brady topped 400 passing yards for the first time since Week 5 heading into the Buccaneers' Week 18 matchup against a Carolina defense that has allowed the second-fewest passing yards to opposing quarterbacks this season.
Sam Darnold hasn't found the end zone in 58 pass attempts across two games since returning from a five-contest absence , and he'll now head into a Week 18 matchup against a Tampa Bay defense that has been middling against opposing quarterbacks this season.
Trey Lance threw two touchdown passes while rushing for 31 yards in the 49ers' last game, and if Jimmy Garoppolo (thumb) is forced to miss another game, Lance could have a solid scoring floor in a Week 18 matchup against a Rams defense that's given up 0.6 TD passes and the 11th-fewest fantasy points per game to opposing QBs over the last five weeks.
Matt Ryan has failed to record multiple touchdowns in eight consecutive games heading into Atlanta's Week 18 matchup against a New Orleans defense that has allowed only 24 total touchdowns to opposing quarterbacks this season.
Mac Jones has been up and down over his last four games for the Patriots, and in Week 18, he'll get a Dolphins defense that ranks ninth in pass DVOA so far in 2021.
Trevor Lawrence threw his second touchdown pass in the past nine games last week, but he also threw three interceptions to bring his season total to 17, and in Week 18, the struggling Jaguars rookie quarterback will face a motivated Colts team that needs a win to secure a playoff berth.
Mike Glennon guided the Giants offense to one of the worst performances statistically in the history of the NFL last game; needless to say, he is not a recommended option in Week 18 even against a suspect Washington secondary allowing 265.6 passing yards per game, which is 30th in the NFL.
Tua Tagovailoa is averaging under 200 yards passing with just one touchdown over his last three games for the Dolphins, and in Week 18, he'll get a Patriots defense that ranks third in pass DVOA this season.
Zach Wilson has thrown a touchdown in just five games this season for the Jets, and in Week 18, he'll get a Buffalo defense that ranks second in pass DVOA so far in 2021.