Baker Mayfield hasn't thrown for a touchdown in any of his past three games for the Browns, but in Week 12, he gets a Jaguars defense that has allowed 21 scores through the air, just two shy of the most in the league.
Josh Allen showed a few issues with protecting the ball for the Bills prior to the bye week, but he'll get an opportunity to get back on track against a Chargers defense in Week 12 that's allowed 17 passing touchdowns in their last seven games.
Derek Carr threw three touchdowns last week for the third time this season, and the Raiders quarterback figures to air it out frequently in Week 12 on the road against a Falcons defense that ranks second-last in the league in passing yards per game allowed and passing TDs allowed.
Philip Rivers has a trio of three-touchdown performances in his last five games heading into a Week 12 matchup with a Titans defense that the veteran Colts quarterback carved up for over 300 yards two weeks ago.
Justin Herbert has thrown multiple touchdowns in a remarkable seven straight games, posting a 20:4 TD:INT over that stretch, and the Chargers rookie figures to extend that streak in Week 12 against a Bills defense that ranks 22nd in QB rating against.
Carson Wentz has as many interceptions as touchdowns thrown in 2020 for the Eagles, but should still start Week 12's clash with the Seattle Seahawks, whose defense is allowing a league-worst 343.7 passing yards per contest.
Patrick Mahomes has thrown for more than 340 yards in three straight games with an 11:1 TD:INT, and the Kansas City superstar may not slow down in Week 12 against a Buccaneers defense that just got lit up by Jared Goff on Monday night.
Ryan Finley is set to take over under center in Week 12 for the Bengals where he'll get a Giants defense allowing 275.2 receiving yards per game, the seventh-highest total in the league.
Deshaun Watson has thrown for 300-plus yards in five of his last seven games, and given his lack of support from the defense and running game, Houston's star quarterback will likely shoulder a heavy Week 12 load against a Lions defense that's allowing 28.7 points per game.
Matthew Stafford will need to overcome a thumb injury that clearly limited him in the Lions' shutout loss last week if he's to succeed against a feast or famine Texans defense on Thanksgiving in Week 12, a unit that's allowed just two touchdown passes over the last three weeks, but 283 or more yards in five of their last six.
Jared Goff has thrown multiple TD passes in four of the Rams' last six games, and he'll look to keep that trend going in Week 12 against a 49ers defense that's allowed nine TD passes over their last three games.
Cam Newton piled up yards for the Patriots, but couldn't pull off the win heading into Week 12 against the Cardinals, who have allowed multiple touchdowns in four-straight games.
P.J. Walker and the Panthers have a tricky Week 12 matchup against an improving Vikings defense that allowed the seventh-most fantasy points to QBs over the first six games of the season (25.7) but only the 19th-most (20.0) since.
Taysom Hill and the Saints have a tough Week 12 matchup against a Broncos defense that has allowed the seventh-fewest yards per pass attempt (6.5) while grabbing the sixth-most interceptions (4) leaguewide over the past four weeks.
Should he be available to play, Teddy Bridgewater and the Panthers have a tricky Week 12 matchup against an improving Vikings defense that allowed the seventh-most fantasy points to QBs over the first six games of the season (25.7) but only the 19th-most (20.0) since.
Kyler Murray (shoulder) has accounted for multiple TDs in each of Arizona's games, and he'll look to extend that streak in Week 12 against a Patriots defense that's given up at least two TD passes in each of their last three games.
Possibly playing without star receiver Julio Jones, Matt Ryan and the Falcons will be tested in a Week 12 matchup with a Raiders defense that is 13th in total touchdown passes allowed (16) and 18th in yards allowed per pass attempt (7.3) through 10 games in 2020.
Daniel Jones has just eight passing touchdowns in 2020 for the Giants, but five of them have come in his last four games, and he will face a lackluster Bengals passing defense in Week 12 that's allowed 22 throwing scores this season, which is tied for 29th in the league.
Aaron Rodgers continues at a torrid scoring pace and has now thrown for over 300 yards in three straight to boot, but faces a challenging matchup in Week 12 when the Packers face the Bears, a defense that's allowed multiple passing TDs in four straight, but only 12 total and allow just 6.8 yards per attempt.
Alex Smith has just two touchdown passes since entering the lineup for Washington, but will face a Cowboys defense in Week 12 that's surrendered the most passing touchdowns in the NFL this season.
Tua Tagovailoa struggled to the point of being benched for Ryan Fitzpatrick, but is still likely to be the starter for the Dolphins heading into a much more permissive matchup against the Jets' youthful secondary in Week 12.
Russell Wilson has thrown for multiple TDs in all but one of the Seahawks' games, and he'll have a challenging Week 12 matchup against an Eagles defense that's allowed just 1.3 passing TDs per contest.
Sam Darnold missed another game for the Jets with a shoulder injury heading into Week 12 against the Dolphins, who are in the bottom-10 against the pass this season.
Drew Lock has thrown an interception in six straight games, posting a poor 6:11 TD:INT over that stretch, and he'll be a risky option in Week 12 as the Broncos host a Saints defense that ranks eighth in QB rating against.
Mitchell Trubisky could return under center for the Bears in Week 12 against a Packers defense allowing 7.8 yards per attempt if he's able to overcome a shoulder injury, as Nick Foles is also uncertain to play due to a hip issue.
Jake Luton has a 2:6 TD:INT through three starts for the Jaguars after being picked off four times in his last outing, but if Gardner Minshew (thumb) isn't ready to return in Week 12, Luton should be right back under center against a Browns defense that's allowing 247.9 passing yards per game.
Tom Brady and the Buccaneers have a tough Week 12 matchup against a Chiefs defense that has allowed the fourth-fewest yards per pass attempt (6.18) and the seventh-fewest passing touchdowns (7) since Week 6.
Kirk Cousins has eight touchdowns and only one interception over the last three weeks, but the Vikings could be without top WR Adam Thielen (Covid) in Week 12 against a vulnerable Panthers run defense, likely limiting Cousins' chances to impact the game as a result.
Nick Foles has just four touchdowns in the Bears last four games, and is uncertain to start in Week 12 against a Packers defense that's allowed seven touchdown passes in their last four games due to a hip injury.
Ben Roethlisberger has thrown for at least 260 yards and two scores in four of his past five outings for the Steelers, but in Week 12, he gets a Ravens defense that held him to 182 yards passing four weeks ago and ranks eighth in the league allowing just 235.2 receiving yards per game.
Andy Dalton tossed three touchdowns in a triumphant return to the starting lineup for Dallas, but will face a stiff task in Week 12 versus a Washington defense allowing the fewest passing yards per game in the NFL in 2020.
Ryan Fitzpatrick subbed in for the final quarter for Tua Tagovailoa and could compete for the start against his former team, the Jets, in Week 12 who have allowed the fourth-most fantasy points to opposing quarterbacks this season.
Joe Flacco only completed 50 percent of his passes, but hit a number of deep balls for the Jets in relief of Sam Darnold heading into Week 12 against the Dolphins, who are allowing the ninth-most fantasy points per game to opposing quarterbacks.
Ryan Tannehill boasts an impressive 22:4 TD:INT this season and a 44:10 mark in his time with the Titans, but Week 12 presents a daunting rematch against a Colts defense that held him to 147 yards and a touchdown two weeks ago.
Gardner Minshew has missed the past three games due to a thumb injury, but Jacksonville's starting quarterback will hope to prove himself healthy enough to take the field in Week 12 against a Browns defense that has held its last three opponents to 40 points combined.
Lamar Jackson has been held to fewer than 200 yards passing and two touchdowns in three of his past five games for the Ravens, and in Week 12, he gets a Steelers defense allowing 229.5 receiving yards per game, the sixth-lowest total in the league.
Nick Mullens has thrown for at least 238 yards and one TD in each of the 49ers' last three games, but he'll have a tough Week 12 matchup against a Rams defense that's allowed the fewest TD passes in the league this season.