Damien Harris struggled to find yardage, but did plunge in a touchdown run for the Patriots heading into Week 12 against the Cardinals, who have been right in the middle of the pack against the run this season.
Tyler Bass hit all of his field goals including a 58-yarder in the last game prior to the Bills bye week, and the Bills' high-octane offense should lend Bass plenty of scoring opportunities in Week 12 against the Chargers.
Nelson Agholor scored his sixth touchdown of the season last week, and the Raiders' top wideout figures to pad his totals further in Week 12 on the road against a Falcons defense that ranks second-last in the league in passing yards per game allowed and passing TDs allowed.
Breshad Perriman hauled in a 49-yard touchdown pass as his blistering speed and Joe Flacco's arm-strength could be a perfect pairing for the Jets heading into Week 12 against the Dolphins and their bottom-10 secondary.
Tyler Lockett has failed to surpass 67 yards in six of the Seahawks' last seven games, and he could struggle to break that trend in Week 12 against an Eagles defense that's allowed just four WRs to top 80 yards this season.
Kyler Murray (shoulder) has accounted for multiple TDs in each of Arizona's games, and he'll look to extend that streak in Week 12 against a Patriots defense that's given up at least two TD passes in each of their last three games.
Possibly getting another start in place of Christian McCaffrey, Mike Davis and the Panthers have a Week 12 matchup against a Vikings run defense that has only allowed one rushing touchdown since Week 5.
Daniel Jones has just eight passing touchdowns in 2020 for the Giants, but five of them have come in his last four games, and he will face a lackluster Bengals passing defense in Week 12 that's allowed 22 throwing scores this season, which is tied for 29th in the league.
Gabriel Davis is pretty firmly down the Bills' passing game pecking order heading into Week 12 against the Chargers and their middle-of-the-pack secondary.
Todd Gurley and the Falcons have a so-so Week 12 matchup against a Raiders defense that has allowed just 3.9 yards per rush (13th) with five rushing touchdowns (22nd) over its past five games.
DJ Chark has found more consistency with 15 catches in three games since Jake Luton took over under center after a boom-or-bust start to the season alongside Gardner Minshew, but Jacksonville's top receiver will look to put his big play ability on display regardless of who's throwing him the ball in Week 12 against a Browns defense that has allowed 12 touchdowns to wide receivers.
Zack Moss seems to be the 1a in the Bills backfield heading into a positive matchup against the Chargers in Week 12, who have allowed seven rushing touchdowns in their last five games.
Anthony Miller has seen 26 targets over the Bears last three games, and while Chicago has questions under center entering a Week 12 matchup against Green Bay, the Packers have struggled to defend slot receivers as team's pick on other corners and shy away from top CB Jaire Alexander.
Damiere Byrd did an excellent job of asserting himself in the Patriots offense, breaking the 100-yard threshold and catching a touchdown while having other opportunities where he was wide open heading into another positive matchup against the Cardinals in Week 12 if he doesn't draw Patrick Peterson.
Denzel Mims saw a team-high eight targets but his boom-or-bust routes led to just three receptions as he's quickly grown into a crucial option in the Jets passing game heading into Week 12 against the Dolphins and their bottom-10 fantasy secondary.
Jonathan Taylor reclaimed his spot atop the Colts' running back depth chart with 114 scrimmage yards on 26 touches last week, and the rookie will look to build off that momentum in Week 12 against a Titans defense that held him to a career-low 12 rushing yards in their first meeting.
Darius Slayton is averaging 15.4 yards per catch for the Giants in 2020, which is 14th in the NFL, and will face a lackluster Bengals defense in Week 12 allowing 254.7 passing yards per tilt, which is 23rd in the NFL.
Ian Thomas and the Panthers have an interesting Week 12 matchup against a Vikings defense that allowed the fourth-most yards per pass attempt (9.8) over the first six games of the year but the third-fewest (6.90) since.
Amari Cooper did have seven catches for 80 yards when Dallas played Week 12 opponent Washington last month, though Washington is allowing the fewest passing yards per game in the NFL this season, and Cooper has not scored a touchdown in over a month.
Tee Higgins has seen 28 targets over his past three outings for the Bengals, and in Week 12, he gets a Giants defense allowing 172.3 receiving yards per game to his position, the 13th-highest total in the league.
Benny Snell has not topped 20 rushing yards since the season opener, but heading into Week 12, Baltimore ranks in the middle of the pack allowing 90.8 rushing yards per game to his position.
Michael Badgley has connected on multiple field goals in four of the last five games, and he could see plenty of opportunities again in Week 12 as the Chargers face a Bills team allowing 26.5 points per game, 20th in the league.
Miles Boykin has not seen a target over his past two games for the Ravens, but in Week 12, he gets a Steelers defense that ranks in the middle of the pack allowing 159.8 yards per game to his position.
Chad Beebe has seen only three total targets in the Vikings last four games, but could be forced into a larger role in Week 12 against a Panthers defense that's allowing 270 passing yards per game if Adam Thielen (Covid) is unable to play.
Brandon McManus has kicked multiple field goals in three straight games, but his opportunities could be limited in Week 12 as the Broncos host a Saints team allowing 22.2 points per game, eighth in the league.
Possibly helping fill in for Julio Jones (hamstring), Russell Gage and the Falcons have a Week 12 matchup with a Raiders defense that is 13th in total touchdown passes allowed (16) and 18th in yards allowed per pass attempt (7.3) through 10 games in 2020.
Adam Thielen has scored four times over the last two weeks, and 11 times on the year, and would have a great chance to add to those numbers for the Vikings in Week 12 against a Panthers secondary that's allowed 16 TD passes to date, but will need to be removed from the Reserve/Covid-19 list before suiting up.
Eric Ebron has drawn a red-zone target in each of the last six games for the Steelers, and in Week 12, he gets a Ravens defense that has allowed five touchdowns to tight ends this season, three off the league lead.
Should he be available to play, Teddy Bridgewater and the Panthers have a tricky Week 12 matchup against an improving Vikings defense that allowed the seventh-most fantasy points to QBs over the first six games of the season (25.7) but only the 19th-most (20.0) since.
Jason Myers has connected on multiple field goals in four of the Seahawks' last five games, and he could keep that streak going in Week 12 against the Eagles, who allow two field-goal attempts per game.
Taysom Hill and the Saints have a tough Week 12 matchup against a Broncos defense that has allowed the seventh-fewest yards per pass attempt (6.5) while grabbing the sixth-most interceptions (4) leaguewide over the past four weeks.
Will Dissly could be in line for an increase in targets for the Seahawks after Greg Olsen (foot) landed on IR, and he could be set up for solid production in a Week 12 matchup against an Eagles defense that's allowed the fifth-most fantasy points to tight ends.
Chris Herndon hauled in a touchdown, his first of a woebegone season for the Jets, heading into Week 12 against the Dolphins who have allowed three touchdowns to opposing tight ends in their last three games.
Nyheim Hines has been relegated back to a lesser role after a brief stint as the Colts' lead back, but his pass-catching ability out of the backfield should keep Hines involved in Week 12 against a Titans defense that he burned for 115 scrimmage yards and two touchdowns two weeks ago.
John Brown's inability to stay healthy is the only thing keeping him from being a consistent second option in the Bills' pass-happy offense heading into Week 12 against the Chargers and their mid-range secondary.
Keke Coutee found the end zone last week after Randall Cobb hurt his toe, and Coutee's expected to fill in for Cobb as Houston's slot receiver in Week 12 against a Lions defense that has allowed the fifth-most yards to wide receivers this season.
Willie Snead has seven targets in three of his past four games for the Ravens, and in Week 12, he gets a Steelers defense that ranks in the middle of the pack allowing 159.8 yards per game to his position.
Dallas Goedert led the Eagles in receiving last game while also finding the end zone, though the possible return of Zach Ertz to the lineup could stunt his progress, even in Week 12 versus a Seattle defense allowing a staggering 343.7 passing yards per outing.
Jared Goff has thrown multiple TD passes in four of the Rams' last six games, and he'll look to keep that trend going in Week 12 against a 49ers defense that's allowed nine TD passes over their last three games.
Harrison Butker has kicked at least three extra points in four straight games but didn't see a field-goal attempt in two of them, and Kansas City's offensive efficiency makes him a volatile option in Week 12 against a Buccaneers team allowing 23.0 points per game, 10th in the league.
Zach Pascal has racked up at least 54 receiving yards in four of his last seven games but hasn't surpassed 58, as his ceiling continues to be capped in a Colts offense that likes to spread the ball around heading into a Week 12 matchup with the Titans.
Mike Williams has posted a solid 16-290-2 line on 27 targets over the last four games, and the Chargers' No. 2 wideout could be productive again in Week 12 against a Bills defense that ranks 17th in passing yards per game allowed.
Should he be cleared to play, Christian McCaffrey and the Panthers have a Week 12 matchup against a Vikings run defense that has only allowed one rushing touchdown since Week 5.
DK Metcalf has been held to 47 yards or fewer in three of the Seahawks' last five games, and he'll have a challenging Week 12 matchup against an Eagles defense that's allowed just four WRs to top 80 yards this season.
Jordan Reed posted 62 yards in the 49ers' last game, and he could be a focal point of the passing attack in Week 12 against a Rams defense that's been a middling unit in terms of fantasy production allowed to TEs this season.
Curtis Samuel and the Panthers have an interesting Week 12 matchup against a Vikings defense that allowed the fourth-most yards per pass attempt (9.8) over the first six games of the year but the third-fewest (6.90) since.
Tim Patrick is coming off his third 100-yard performance of the season, but the Broncos wideout could have trouble repeating those numbers in Week 12 against a Saints secondary that ranks 11th in passing yards per game allowed.
Devin Singletary struggled prior to the bye week and seemed to have slipped behind Zack Moss in the RB pecking order, but could find more room to run for the Bills heading into a matchup with the Chargers, who have allowed seven rushing touchdowns over their last five games.
Kareem Hunt has failed to top 70 yards or score just once all season for the Browns, and in Week 12, he gets a Jaguars defense allowing 97.3 yards on the ground per game to his position, the 13th-highest total in the league.
Miles Sanders has not found the end zone since October 11th for Philadelphia, but will face a Seahawks defense in Week 12 that's surrendered 15 rushing scores thus far in 2020, which is tied for 28th in the league.