Ryan Mathews missed the last two games due to an injured knee, but he is expected to play this Sunday against a weak Washington Redskins run defense that ranks 29th in the NFL in production allowed to opposing running backs.
Tevin Coleman saw his role expand to 12 carries against the Chiefs, turning it into 49 yards, but ceded the red zone work to Devonta Freeman, which significantly depresses his value on Sunday against the Rams’ middling run defense.
Derrick Henry has fresh legs while DeMarco Murray deals with a toe injury and a heavy workload entering 14 against the Denver Broncos, who rank 28th in rushing defense.
Mike Gillislee swiped two touchdowns from teammate LeSean McCoy last weekend, and faces a Pittsburgh defense in Week 14 that's yielded 10 rushing scores in 2016, which is tied for 19th in the NFL.
Ty Montgomery resurfaced to lead the Packers in rushing last week, and his dual position eligibility give him a shot at relevance against a tough Seahawks defense that is allowing only 99.3 yards per game rushing.
Paul Perkins had seven carries for 38 yards to lead the New York Giants in rushing last Sunday, though he still played a lesser role in the offense than starter Rashad Jennings due to the latter's receiving and blocking abilities, making Perkins a risky play against a tough Dallas Cowboys defense that is fourth in the NFL in production allowed to opposing running backs.
Rex Burkhead will take on the Browns this Sunday after posting at least 48 yards in each of his last two games since taking over for Giovani Bernard.
Bilal Powell touched the ball just once on Monday Night Football, but has a chance to rebound on Sunday against the league's worst rushing defense of the San Francisco 49ers, a unit that's allowed a staggering 169.3 rushing yards per game in 2016.
Kenneth Dixon will have a Week 14 matchup against the Patriots after posting at least 77 total yards in three of his last four games, though he’s yet to find the end zone in his rookie campaign.
Jerick McKinnon scored and averaged 4.6 yards per carry last week, two things he hadn't done since Week 4 against the Giants, giving him a but of momentum entering Sunday's matchup with the Jaguars 24th ranked rush defense that allows 115.6 yards per game.
Playing from behind, the Saints ran the ball a total of 12 times last week and their willingness to abandon the run game bodes poorly for Tim Hightower on Sunday against the Bucs, who have allowed just one 100-yard rusher this season.
Alfred Blue returned to action last week after missing two games with a calf injury, but needs a significant injury to Lamar Miller to have any value in Week 14 against the Indianapolis Colts, who rank 20th in run defense.
Darren Sproles carried seven times and added six receptions for 49 total yards and a touchdown last week against the Cincinnati Bengals, and should maintain his usual role with Ryan Mathews returning this week against a poor Washington Redskins run defense that ranks 29th in the NFL in production allowed to opposing running backs.
Matt Asiata saw a three-game scoring streak snapped last week and has six or fewer carries in three straight games giving him minimal upside against a Jaguars 24th ranked rush defense that allows 115.6 yards per game.
Wendell Smallwood was held to 19 yards on eight carries and three unsuccessful targets last Sunday against the Cincinnati Bengals, and with Ryan Mathews expected to return this week Smallwood is facing a return to a pure back-up role against the Washington Redskins.
Dwayne Washington remains a complimentary piece to the Lions limited rushing attack, giving him next to no appeal against a Bears defense that allows just 3.9 yards per carry.
Robert Turbin is Frank Gore's touchdown stealer, having scored four times this season as the Indianapolis Colts prepare for the Houston Texans, who have been susceptible to the running game.
Denard Robinson has picked up increased playing time the last two weeks as Chris Ivory (hamstring) and T.J Yeldon (ankle) deal with injuries, but Robinson was forced to leave last week's game with a high-ankle sprain and will be questionable for Week 14 against the Minnesota Vikings.
Jonathan Grimes, along with Alfred Blue, will get some touches each week, but he's no threat to Lamar Miller's top spot in the backfield entering Week 14 against the Minnesota Vikings.
Corey Grant is a little used on offense, but has the distinction of being the healthiest running back on the Jacksonville Jaguars' roster entering Week 14 against the Minnesota Vikings' 17th-ranked rushing defense.
Jalen Richard saw a season-high nine carries last week, but with Latavius Murray healthy he won't see enough touches to be reliable Thursday, even in a favorable matchup against a soft Chiefs run defense.
Christine Michael saw an expanded role in his second week with the Packers last Sunday, but will continue to split carries with at least Ty Montgomery entering a matchup with his former team in the Seahawks, who allow only 99.3 yards per game on the ground.
Justin Forsett hasn't seen action since Week 7, but could see a handful of snaps right away as Devontae Booker's main backup given familiarity with Gary Kubiak's offense from their days together in Baltimore.