Le’Veon Bell will take on the Browns this Sunday, but there’s a strong possibility that the team will rest him, as the Steelers have clinched the third spot in the AFC, making this a meaningless game.
Jordy Nelson has multiple touchdown catches in two of his last three games entering Sunday night's showdown for the NFC North crown against the Lions, a defense he put 101 yards and two scores up against in a Week 3 meeting.
Jesse James will have a Week 17 tilt against the Browns, who have allowed four touchdowns to opposing tight ends over the last three weeks.
Ladarius Green will take on the Browns in Week 17 after missing last week’s game with a concussion, and it seems unlikely that the Steelers will use him in a game that has no playoff implications.
Antonio Brown will have a Sunday tilt against the Browns, but it’s very possible that the team will significantly limit his playing time, due to the fact that the Steelers have clinched the third seed in the AFC playoffs.
Brandin Cooks has 24 receptions for 418 yards over his past four games since turning in a duck against the Rams, but faces a Falcons secondary in Week 17 that held him to two receptions and eight yards in Week 3.
Marqise Lee looks to finish off a breakout season in Week 17 against the Indianapolis Colts' 25th-ranked rushing defense 273.7 ypg).
Zach Ertz has over 300 yards in his past four games combined, and should be able to stay on that pace Sunday against the 28th-ranked Cowboys pass defense.
Odell Beckham has 504 yards and four touchdowns over the past five weeks, and will look to stay hot Sunday against cornerback Josh Norman and the 27th-ranked Redskins pass defense.
Sammy Watkins is coming off his first 100-yard game of the season, and will face a suspect Jets secondary on Sunday that's allowing 249 passing yards per game, which is 20th in the league.
Adam Thielen has at least 86 yards in three of his last four games and has emerged as the Vikings top receiving threat entering a Week 17 finale against a Bears secondary that has allowed three receivers to top 93 yards in the last two games.
Mike Evans will look to cap off his career year against a Panthers secondary on Sunday that’s allowed a league-worst 291 receiving yards per game.
T.Y. Hilton looks to finish out a nice bounce-back season in Week 17 when the Indianapolis Colts face the three-win Jacksonville Jaguars, who rank sixth in yards allowed per game to wideouts (144.7 ypg).
Jimmy Graham is primed for another big game Sunday against a 2-13 49ers team that he burned for 100 yards and a touchdown back in Week 3.
Brandon LaFell will have a Sunday tilt against the Ravens after posting at least 91 receiving yards and three of his last four games.
Julian Edelman needs 45 receiving yards on Sunday for the second 1,000-yard season of his career, and will face a Miami Dolphins defense allowing 240 passing yards per contest, which is 13th in the NFL.
LeSean McCoy has four 100-yard games in his last five contests while scoring six touchdowns over that span, and will face a reeling New York Jets rushing defense in Week 17 that's allowing over 100 yards per game on the ground this season.
LeGarrette Blount scored two touchdowns last weekend, but faces a Miami defense in Week 17 that's allowed only 11 scores on the ground in 2016, which is tied for 12th in the NFL.
Mark Ingram is just 60 yards away from his first 1,000-yard season, and faces a Falcons defense on Sunday that’s allowed the eighth-most yards per attempt this season.
Delanie Walker will have to adjust to a new quarterback in Week 17 as Matt Cassel replaces the injured Marcus Mariota (fibula) against the Houston Texans, who rank third in yards allowed per game to tight ends (35.4 ypg).
Doug Baldwin just burned Arizona for 13 catches and 171 yards last week, so a strong encore is likely Sunday against a 49ers defense that has allowed a league-worst 30.3 points per game.
Charles Clay has scored in three-straight games, and faces a suspect New York Jets passing defense on Sunday that's allowed 30 passing scores in 2016, which is tied for 30th in the NFL.
Bilal Powell should see the bulk of the carries Sunday against the Buffalo Bills, whose defense is allowing a subpar 133.5 rushing yards per game.
DeSean Jackson has topped 100 yards in four of his past five games heading into Sunday's crucial matchup against a Giants team he loves to face.
Greg Olsen has 16 receptions over his past three games, and will look to replicate his nine catch, 181 yard performance from Week 5 against the Bucs on Sunday.
Sterling Shepard has scored six times in his past eight games, and has a good chance of finding the end zone once again Sunday against the 27th-ranked Redskins pass defense.
David Johnson has found pay dirt 20 times this season, and will be motivated to add to that total Sunday against a Rams team that surprisingly kept him from scoring back in Week 4.
Thomas Rawls is expected to be back from last week's shoulder bruise in time to exploit San Francisco's league-worst rushing defense in Week 17.
Cameron Meredith has scored or topped 100 yards in three straight games, seeing 33 targets in that span entering Sunday's season finale against a Vikings defense that has allowed six touchdown passes in the last two weeks.
Eli Rogers will face the Browns in Week 17, after averaging 79.5 yards along with one touchdown over his last two contests.
Michael Thomas is just 19 yards away from 1,000 yards in his rookie season, and leads all rookies in receptions, yards, touchdowns and any other receiving category you can think of; he's nearly a lock to reach his milestone Sunday against the Falcons.
Cameron Brate injured his back last week on his second target, but if he can suit up, will be a strong play on Sunday against the permissive Panthers defense that’s allowed 12 touchdowns to opposing tight ends.
Jordan Howard has at least 99 total yards in eight straight games, a streak that started in his first matchup with Sunday's opponent, the Minnesota Vikings, whom he gashed for 153 yards and a score on 26 carries.
Coby Fleener had his biggest game of the season in the first meeting with the Falcons (seven receptions, 109 yards and a touchdown), but has just five receptions for 49 yards over his past three.
Injuries to T.J. Yeldon (ankle) and Chris Ivory (hamstring) make Grant a possible lead back for Week 17 against the Indianapolis Colts, who rank 23rd in rushing defense (116.3 ypg).
Alshon Jeffery has at least eight target in six straight games and is averaging 90.5 yards in his two games since returning from suspension, seemingly giving him a safe floor even if he's matched up exclusively with Vikings corner Xavier Rhodes on Sunday.
Robert Turbin is tied for second on the Indianapolis Colts with seven touchdowns (six rushing, one receiving) and has scored four times in the last four games entering Week 17 against the Jacksonville Jaguars, who rank 23rd in rushing touchdowns allowed.
Alex Collins will serve as the primary running back against the league-worst 49ers run defense Sunday if Thomas Rawls (shoulder) can't suit up, but Rawls is expected to play.
Tyreek Hill failed to catch any of his five targets last week but scored his third rushing TD in five games, and the Chiefs should be committed to getting the ball in his hands once again Sunday as they look to keep their chances of an AFC West title alive.
Golden Tate has at least six catches in four straight games entering a season finale matchup with Green Bay's 29th ranked pass defense that allows 265 yards per game.
Devontae Booker set career highs in targets, catches and receiving yards last week, and could see a larger workload Sunday against the Raiders with the Broncos eliminated from the playoffs and in talent evaluation mode.
Kyle Rudolph has at least eight targets in five straight games, but has topped 65 yards and scored just once in that span, giving him a safe floor with limited upside against a Bears defense that has allowed one tight end to top 50 yards since Week 10, and just two all season.
Kenneth Dixon will have a Week 17 matchup against the Bengals, who he posted 80 total yards against in Week 13.
The Tennessee Titans, with playoff hopes dashed last week, could limit DeMarco Murray in Week 17 against the Houston Texans.
Rishard Matthews looks to finish off his breakout season in Week 17 against the Houston Texans, who rank second in receiving defense (218.3 ypg).
The beneficiary of another healthy scratch of Doug Martin, Jacquizz Rodgers will look to run wild on Sunday against a Panthers defense Rodgers shredded for 101 rushing yards in Week 5.
If the Tennessee Titans choose to rest or limit DeMarco Murray in a game that has no playoff implications, Derrick Henry could get the bulk carries in Week 17 against the Houston Texans.
Tyler Boyd will face the Ravens on Sunday after catching five passes for 62 yards in his last meeting against them.
J.J. Nelson takes a four-game scoring streak into Sunday's season finale against the ninth-ranked Rams pass defense.
Jordan Matthews is battling through an ankle injury, but should still be able to find success against a 28th-ranked Cowboys secondary that has allowed 264.7 passing yards per game.