Chase Edmonds has posted at least 82 yards in each of Arizona's last two games, but if James Conner (heel) returns, he could see a reduced workload in a Week 18 matchup against a Seattle defense that's allowed the fifth-most fantasy points to opposing RBs over the last five weeks.
Josh Jacobs has piled up 570 scrimmage yards and three touchdowns over the last six games, and he figures to be productive again in Week 18 with a wild-card spot on the line as the Raiders take on a Chargers defense that ranks in the bottom four in rushing yards per game allowed and rushing TDs allowed.
AJ Dillon is coming off his first double-digit carry outing in three weeks, and seems destined for a heavy workload for the Packers in Week 18, either with Aaron Jones getting limited work with the No. 1 seed clinched, or as a hammer to ice the game once a comfortable lead is built, giving him upside against a Lions team that's allowing 135.8 yards per game.
Van Jefferson is averaging 31 receiving yards over the Rams' last three games, and he'll likely need to find the end zone to have upside in a Week 18 matchup against a 49ers defense that's allowed 183 receiving yards per game and the third-most fantasy points to opposing WRs over the last five weeks.
Laquon Treadwell has been Jacksonville's most productive wide receiver down the stretch with over 50 yards in each of his past six games, but he's still searching for his first touchdown of the season heading into the Week 18 season finale against a Colts secondary that's been burned for 19 touchdowns by wide receivers.
Matthew Stafford has a 5:6 TD:INT ratio over the Rams' last three games, but he should have a strong scoring floor in a Week 18 matchup against a 49ers defense that's allowed 1.6 TD passes per game and the 16th-most fantasy points to opposing QBs over the last five weeks.
Rashard Higgins has topped 30 yards just twice this season for the Browns, but in Week 18, he gets a Bengals defense that ranks 24th in pass DVOA so far in 2021.
Marquez Callaway posted six receptions for the second time in his last three games a s the leads of the Saints' wide receiver corps, and he could be in for another big workload in a Week 18 matchup against Atlanta -- particularly if Tre'Quan Smith remains sidelined.
Brandon Aiyuk has posted at least 36 yards in each of the 49ers' last five games, and he'll continue to have a moderate scoring floor in a Week 18 matchup against a Rams defense that's given up over 180 yards and the 13th-most fantasy points per game to opposing WRs over the last five weeks.
Justin Jefferson has seen at least nine targets in eight straight contests, but has now failed to score in two weeks while being held to 58 yards or less in two of three, and likely needs Kirk Cousins under center for the Vikings in Week 18 if he's to close the year with a bang against a Bears' defense that's allowed only four 100-yard receivers to date.
Dalvin Cook struggled last week with the Vikings using a backup quarterback, and could need Kirk Cousins to return in Week 18 if he's to find more running room against a Bears defense that allows 4.4 yards per carry, but bottled Cook up for 3.2 ypc three weeks prior.
Sammy Watkins does not have a catch in any of his last three games for the Ravens, and in Week 18, he gets a Steelers defense that ranks 13th in pass DVOA in 2021.
Jamaal Williams led the Lions backfield last week despite the return of D'Andre Swift, making for a bit of a guessing game as to how touches will be distributed in Week 18 against the Packers, a team that's allowing a vulnerable 4.8 yards per carry.
Carson Wentz has an efficient 26:6 TD:INT in his first season with the Colts, but he has thrown for more than 180 yards only twice in his last seven starts, and the team will likely move the ball primarily on the ground in Week 18 against the 2-14 Jaguars.
Jared Goff remains uncertain to start for the Lions in Week 18 due to a knee injury, but should he gain clearance, he'll face a Green Bay defense that's allowed multiple touchdown passes in five of their last six games, and could rest starters at some point with the No. 1 seed already clinched.
K.J. Osborn has scored in four of the Vikings last five games with Adam Thielen sidelined, topping 50 yards twice, and while the lone game he didn't score in was against his Week 18 opponent in the Bears, their secondary has been vulnerable to scores, allowing 12 TD passes in five games, setting Osborn up to continue his strong close to the season.
Taylor Heinicke has thrown multiple touchdown passes just twice in the last 11 games for Washington but will face a reeling Giants defense in Week 18 that's surrendered nine passing scores during its current five-game losing streak.
Nico Collins scored his first career touchdown two weeks ago with Brandin Cooks sidelined, but he has delivered modest production as Houston's No. 2 wide receiver with Cooks healthy, though perhaps a Week 18 matchup with a Titans defense that has allowed 2,966 yards to wide receivers - second-most in the league - will help Collins close out his rookie season on a high note.
Tevin Coleman has at least 50 yards in each of his last four games for the Jets, and in Week 18, he'll get a Buffalo defense that ranks 15th in rush DVOA so far in 2021.
Derek Carr has thrown one touchdown or fewer in seven straight games, giving him a limited ceiling in Week 18 with a wild-card spot on the line as the Raiders face a Chargers defense that held him under 200 passing yards in their first meeting, the only team to do so this season.
Tyreek Hill has been held below 80 receiving yards and without a touchdown in four of five games since Kansas City's bye, making him a high-risk, high-reward play in Week 18 against a Broncos defense that ranks seventh in passing yards per game allowed this season.
D'Andre Swift saw only six touches in his first action in five weeks last Sunday, and with the Lions and Packers playing for only pride in Week 18, his opportunities could be few and far between again, making for volatility against a defense that allows 4.8 yards per carry.
Ameer Abdullah has surpass 50 total yards in two of his last four games heading into the Panthers' Week 18 matchup against a Tampa Bay defense that has allowed the fifth-most receptions to opposing running backs this season.
Deonte Harris earned only two targets in his return from a three-game suspension and he'll now head into a Week 18 matchup against an Atlanta defense that has allowed the seventh-most fantasy points to opposing wide receivers this season.
Robby Anderson has recorded 30 or fewer passing yards in two of his four games since the Panthers' bye week, and he now heads into a Week 18 matchup against a Tampa Bay defense that has allowed the ninth-most receiving yards to opposing wide receivers this season.
Rashod Bateman has topped 35 yards just twice over his last seven games for the Ravens, and in Week 18, he gets a Steelers defense that ranks 13th in pass DVOA in 2021.
Javonte Williams is coming off his worst performance since the Broncos' Week 11 bye, but the rookie will look to rebound in Week 18 against a Kansas City defense that ranks 28th in yards per carry allowed.
Jalen Hurts failed to find the end zone last game for the Eagles and it remains to be seen how much he will play in Week 18 versus the Cowboys as both teams have locked up playoff spots and can only maneuver slightly in terms of seeding; if Hurts plays the majority of the contest, he will face a Dallas defense allowing 242.7 passing yards per tilt, which is 24th in the NFL.
Antonio Gibson could return from the reserve/COVID-19 list for Washington in Week 18 and would have a tasty matchup versus a reeling Giants defense allowing 122.9 rushing yards per tilt, which is 23rd in the league.
Patrick Mahomes has a sharp 10:1 TD:INT over the last four games, but he faces a tough challenge in Week 18 as Kansas City takes on a Broncos defense that held him below 200 passing yards and without a TD in their first meeting, the only defense this season to accomplish that feat.
Davis Mills has topped 300 passing yards three times in an up-and-down rookie season for the Texans, and he'll be motivated to close out the season on a high note and make his case for the starting job next season in Week 18 against a Titans defense that has allowed 21 passing touchdowns but also notched 16 interceptions.
George Kittle has been a feast-or-famine producer for the 49ers over the last five weeks, and he'll continue to have upside potential despite a Week 18 matchup against a Rams defense that's given up the fourth-fewest fantasy points to opposing TEs over the last four weeks.
Zay Jones has seen at least seven targets in four straight games, amassing a 25-262-0 line on 32 targets over that stretch, and he should see solid volume again in Week 18 as the Raiders take on a Chargers defense that ranks in the middle of the pack in passing yards per game allowed and passing TDs allowed.
Josiah Deguara has caught two or three passes in nine straight games for the Packers, but has only one score and has topped 35 yards just twice, making him a relatively known commodity in a Week 18 matchup against a Lions defense that's allowed 12 opposing tight ends to top 40 yards against them to date.
Ty Johnson could see a big uptick in touches if Michael Carter (concussion) is out for the Jets, and in Week 18, he'll get a Buffalo defense that ranks 15th in rush DVOA so far in 2021.
Michael Carter has at least 60 total yards in seven of his last eight games for the Jets, and in Week 18, he'll get a Buffalo defense that ranks 15th in rush DVOA so far in 2021.
Mark Ingram will be questionable due to a knee injury for the Saints' Week 18 matchup against an Atlanta defense that has allowed the seventh-most rushing touchdowns to opposing running backs this season.
Ryan Tannehill has topped out at 209 passing yards in his past five games and carries a pedestrian 17:14 TD:INT into the Week 18 regular-season finale against the Texans, but despite the quarterback's mediocre play, the Titans can secure the top seed in the AFC with a win.
Noah Fant is coming off his most productive game since Week 6, but the Broncos' tight end may not be able to repeat the performance in Week 18 against a Kansas City defense that ranks in the middle of the pack in production allowed to TEs.
Kyler Murray has thrown just four touchdown passes over Arizona's last four games, and he'll look to get back on track despite a Week 18 matchup against a Seattle defense that's allowed 1.4 TD passes and the 13th-fewest fantasy points to opposing QBs over the last five weeks.
Dare Ogunbowale scored a receiving touchdown last week to complement his rushing score from the previous game, and he'll continue to work as the primary option in Jacksonville's backfield in Week 18 against a Colts defense that has limited running backs to 12 scrimmage touchdowns.
Elijah Mitchell returned from injury in the 49ers' last game, and he posted 130 total yards and a touchdown, and he'll likely continue to see heavy volume in a Week 18 matchup against a Rams defense that's given up 60 rushing yards and the 14th-fewest fantasy points per game to opposing RBs over the last five weeks.
Saquon Barkley notched his first 100-yard rushing performance since the end of the 2019 campaign for the Giants and will be relied upon heavily in Week 18 versus a fairly stingy Washington run defense allowing 105.1 rushing yards per contest, which is eighth in the league.
DJ Moore has earned a minimum of eight targets in each of his last five games as the Panthers' head into a Week 18 matchup against a Tampa Bay defense that has allowed the fourth-most receptions to opposing wide receivers this season.
Andy Dalton managed only 4.9 yards per attempt in last week's start, but if Justin Fields (ankle) is unable to play for the Bears in Week 18, Dalton would be in a favorable spot against a Vikings defense that allows 7.5 yards per attempt and 28 TD passes to date.
Lamar Jackson has thrown for at least 235 passing yards in all but two of his healthy games this year for the Ravens, and in Week 18, he gets a Steelers defense that ranks 15th in DVOA so far in 2021.
T.Y. Hilton comes into the Colts' Week 18 trip to Jacksonville riding a two-game touchdown streak, but the veteran wide receiver had just one touchdown in his previous seven appearances this season, so he'll be a boom-or-bust option as the Colts look to secure a playoff berth.
A.J. Green has posted at least 64 yards in three of Arizona's last four games, and he should remain productive despite a Week 18 matchup against a Seattle defense that's allowed just two receiving TDs and the eighth-fewest fantasy points to opposing WRs over the last five weeks.
Christian Kirk has recorded at least 79 yards in three of the Cardinals' last four games, and he should continue to be a focal point of the passing attack despite a Week 18 matchup against a Seattle defense that's allowed just two receiving TDs and the eighth-fewest fantasy points to opposing WRs over the last five weeks.
Mark Andrews is averaging over 115 yards with a touchdown over his last four games for the Ravens, and in Week 18, he gets a Steelers defense that ranks 13th in pass DVOA in 2021.