Tyler Eifert will take on the Eagles in Week 13 to face a defense that gave up touchdowns to Jason Witten and Jimmy Graham over their last five contests.
Doug Baldwin caught seven of eight targets for a paltry 34 yards on Sunday against the Tampa Bay Buccaneers, his first game without either 85+ yards or a touchdown since Week 9, and hopes to bounce back this week against a Carolina Panthers defense that struggles to 26th in the NFL in production allowed to opposing wide receivers.
David Johnson had 161 yards from scrimmage plus a touchdown on Sunday against the Atlanta Falcons, making him a perfect 11-for-11 in games over 100 yards to go with his 13 touchdowns going into a match-up against a weak Washington Redskins defense that ranks 25th in fantasy production to running backs.
Jimmy Graham caught six of seven targets for 67 yards on Sunday against the Tampa Bay Buccaneers to give him 264 yards and three touchdowns over his last four games heading into a match-up with a Carolina Panthers defense that has struggled to rank 31st in the NFL in production allowed to opposing tight ends this season.
Tom Brady shrugged off a knee injury to throw for 286 yards and two touchdowns last weekend, and will face a Los Angeles passing defense on Sunday that was just gutted by New Orleans for 346 passing yards and five throwing scores.
Jordan Howard has averaged at least 4.5 yards per carry in each of his last four games while seeing at least 15 carries in each outing, and now faces the league's worst rush defense in San Francisco, which allows 171.8 yards per game and 5.1 yards per carry.
Stephen Gostkowski has missed four field goals and three extra points already this season, though is still not in jeopardy of losing his job, and should see plenty of opportunities in Week 13 against a Los Angeles defense that just gave up 49 points last weekend to the New Orleans Saints.
Julio Jones has four games of 35 or fewer yards (including last week), but six of 100 or more and faces a Chiefs secondary on Sunday that allowed Emmanuel Sanders to go for 162 last week.
Ezekiel Elliott has 97 or more total yards in nine straight games along with 12 total touchdowns, but now faces a tough Minnesota Vikings run defense that ranks eighth in least production allowed to opposing running backs.
Melvin Gordon failed to top 100 yards from scrimmage last week for the first time since Week 6, but could get back on track Sunday against a Buccaneers defense allowing 115.8 rushing yards a game, 22nd in the league.
Colin Kaepernick completed 29 of 46 passes for 296 yards, three touchdowns and an interception while added 113 rushing yards on 10 carries on Sunday against the Miami Dolphins and will look to preserve his positive momentum this Sunday against a Chicago Bears defense that ranks 16th in the NFL in production allowed to opposing quarterbacks but 22nd in rushing yards allowed to those quarterbacks.
Quincy Enunwa tallied the first 100-yard outing of his career this past weekend and should be able to find more success in Week 13 against a Colts defense allowing 279 passing yards per game, which is 30th in the NFL.
Nick Novak ranks 12th with 7.8 points per game entering Week 13 against the Green Bay Packers, who rank 25th in scoring defense.
Odell Beckham caught six of 11 targets for 96 yards and two touchdowns in Week 12, playing through an injured thumb that could still nag him Sunday in a matchup with a PittsburghSteelers defense that is fourth in the NFL in fewest fantasy points allowed to opposing wide receivers.
LeSean McCoy did not appear limited by his thumb injury this past weekend and will face an Oakland defense on Sunday that's allowed 12 rushing scores this season, which is 24th in the league.
Mike Evans has already broken the 1,000-yard barrier this season after his second-consecutive 100-yard performance and faces a Chargers secondary in Week 13 that’s allowed the sixth-most receiving yards per game.
Andrew Luck, who missed Week 12 due to a concussion, practiced early this week and is expected to play in Week 13, a Monday night game against the New York Jets.
Taylor Gabriel has been on fire over the past four games, going for 50-plus yards in each with four touchdowns over that span and could usurp the number two receiver role from Mohamed Sanu in Week 13 against the Chiefs’ bottom-ten fantasy secondary.
Matt Prater has scored 28 points over the last three weeks, connecting from over 40 yards six times, and should see plenty of chances against a Saints defense that allows 27.9 points per game.
Davante Adams has topped 110 yards in three of his last six games, scoring five times, heading into a matchup with a Texans defense that has allowed four opposing receivers to score and two to top 100 yards in the last three games.
Donte Moncrief will look to extend his touchdown streak to five games in Week 13 on Monday night against the New York Jets, who rank 17th in receiving touchdowns allowed.
Golden Tate has seen at least seven targets in six of the last seven games entering a matchup a New Orleans' pass defense that allows over 271 yards per game, 27th in the league.
Steven Hauschka made his only field goal attempt on Sunday against the Tampa Bay Buccaneers, only the third time this season that he hasn't made at least two field goals, and hopes for more activity this week against a Carolina Panthers defense that is tied for 20th in the NFL with 20 made field goals allowed this season.
Matthew Stafford has thrown just five touchdown passes in his last five games, but faces a Saints secondary that has allowed at least two touchdown passes in seven of 11 games to date.
T.Y. Hilton was limited to 25 snaps last week due a back injury, but head coach Chuck Pagano feels he'll be ready for Week 13 on Monday night against the New York Jets.
Jordy Nelson has scored and topped 90 yards in four of the past five games, and faces a Texans defense that has allowed two 100-yard receivers and four different receivers to score over the last three weeks.
Sammy Watkins still managed 80 receiving yards on a limited snap count last weekend in his return from a foot injury, and should see even more looks on Sunday against a suspect Oakland passing defense allowing 273 passing yards per game, which is 28th in the NFL.
Russell Wilson completed 17 of 33 passes for a paltry 151 yards and two interceptions on Sunday, but his 80 rushing yards doubled his season total and suggests that he is finally healthy going into a Week 13 match-up against a Carolina Panthers defense that is tied for 22nd in fantasy production allowed to opposing quarterbacks this season.
Matt Ryan tore up the second-best secondary in terms of net passing yards last week against the Cardinals while only going to Julio Jones for 35 yards and faces a Chiefs defense on Sunday that allowed 368 passing yards to Trevor Siemian last week.
Mohamed Sanu pulled in eight receptions last week, but none went for more than 12 yards, and he could find his niche as Matt Ryan’s check-down option on Sunday against the Chiefs’ bottom-ten secondary.
Vance McDonald caught four of eight targets for 60 yards on Sunday against the Miami Dolphins, giving him 14 receptions for 240 yards and two touchdowns over the last four weeks as he moves into a Chicago Bears defense that is 11th in production allowed to opposing tight ends.
Brandon McManus has kicked multiple field goals in eight straight games, is nine of 11 on the season, and gets a premium matchup Sunday against a Jaguars defense allowing 26.6 points per game, 27th in the league.
Brandon Marshall found the end zone this past weekend for the first time since Week 5, and is a great bet to start a scoring streak in Week 13 against an Indianapolis defense that's allowed 22 passing scores in 2016, which is tied for 27th in the NFL.
Adam Vinatieri ranks 11th with 8.0 points per game entering Week 13 on Monday night against the New York Jets, who rank 21st in scoring defense.
Drew Brees leads the NFL in touchdowns, completion percentage and yards and faces the Lions’ secondary on Sunday that’s allowed the third-most points to opposing quarterbacks.
Justin Tucker will face the Dolphins on Sunday after making 15 field goals in his last six games.
Philip Rivers threw three touchdown passes in Week 12 for the second straight game, and now faces a Buccaneers defense that's given up 20 passing TDs this season, tied for ninth-worst in the league.
Malcolm Mitchell has three touchdowns in his last two games and faces a Los Angeles Rams defense on Sunday that just gave up five passing touchdowns this past weekend to the New Orleans Saints.
Aaron Rodgers has topped 300 yards in three straight games and has 18 touchdowns over his last six games entering a matchup with a fifth-ranked Houston pass defense that allows only 209 yards per game, but has been gashed for six touchdown passes in their last two games.
Dan Bailey made his only field goal attempt last Thursday, his fifth game with one or fewer field goals balanced against four games with three or more, and this week he faces a Vikings defense that is tied for 15th in the NFL in field goal attempts allowed this season.
Julian Edelman has received double-digit targets in each of the last two games, has caught eight passes in each of those contests, and with Rob Gronkowski's status up in the air versus the Los Angeles Rams in Week 13, Edelman should be able to find plenty of room against a defense that just allowed 346 passing yards this past weekend.
Matt Bryant sunk another field goal (from 45) and added five extra points last week and could be a valuable source of scoring in Week 13 against the Chiefs’ top-five scoring defense.
Carson Palmer completed 25 of 45 passes for 289 yards with two touchdowns and an interception on Sunday against the Atlanta Falcons, giving him eight touchdowns and six interceptions over his past four games, a ratio he hopes to improve upon this week against an average Washington Redskins pass defense that ranks 15th against opposing quarterbacks this season.
Josh Lambo failed to kick a field goal in Week 12 for the second time in four games, but should get opportunities Sunday against a Buccaneers defense that's allowing 24 points a game.
Matt Forte managed just 27 yards rushing last weekend but faces an Indianapolis Colts defense in Week 13 that's allowing 116.3 yards per game on the ground, which is 23rd in the league.
Dez Bryant caught five passes for 72 yards last Thursday, giving him 17 receptions for 268 yards and three TDs in his last three games, and he hopes to carry that momentum into this week's matchup against a tough Vikings pass defense that ranks second in least fantasy production allowed to opposing wide receivers.
Devonta Freeman scored twice last week on the ground, but faces a Chiefs defense on Sunday that’s allowed the fewest rushing touchdowns on the season.
DeSean Jackson caught four of eight targets for 118 yards and a touchdown in Week 12, his second straight week with a touchdown, but will be playing through a rotator cuff injury this week against a tough Arizona Cardinals secondary that is seventh in the NFL at limiting production by opposing wide receivers this season.
Phil Dawson made his only field goal attempt on Sunday against the Miami Dolphins and has made all but one of his attempts this season, but has been held to one or fewer made field goals in seven games due to lack of opportunity, a trend that Dawson hopes to change this week against a Chicago Bears defense that ranks 28th in the NFL with 25 field goal attempts allowed this season.
Le’Veon Bell will take on the Giants this Sunday as he tries to become the first running back in six games to rush for more than 77 yards against them.