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San Francisco 49'ers beat their projected point total, but it wasn't enough to swing the result as Buffalo Bills narrowly earned a 231.16-229.20 victory. San Francisco 49'ers had a chance to come from behind on Monday night, but they fell short. Buffalo Bills led 231.16-206.50 after Sunday's action and held on for the win despite a combined 22.7 points from three players on Monday night for San Francisco 49'ers. Tremaine Edmunds (16 Tackles) and Stefon Diggs (6 Rec, 108 Rec Yds, 1 Rec TD) were the stars for Buffalo Bills in the win. This marks the second time this season Buffalo Bills have taken down San Francisco 49'ers, after winning 235.78-210.02 in their last matchup. Buffalo Bills (6-2) will look to maintain their momentum against Green Bay Packers, while San Francisco 49'ers (2-6) try to right the ship against Baltimore Ravens.