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Buffalo Bills beat expectations, earning a 235.78-210.02 win over San Francisco 49'ers, who fell short of projections. San Francisco 49'ers nabbed a 150.92-point lead early Sunday afternoon behind outstanding showings from Brandon Aiyuk, who caught 8 passes for 83 yards and 2 touchdowns for 28.3 points, and Jimmy Garoppolo, who passed for 296 yards and 2 touchdowns and ran for 11 yards (23.52 points). But Buffalo Bills held the lead the rest of the way, powered by Stefon Diggs, who caught 10 passes for 148 yards and a touchdown for 33.8 points, and Josh Allen, who passed for 329 yards and 3 touchdowns and ran for 32 yards (28.78 points). Buffalo Bills (5-1) will look to add to their success against Tampa Bay Buccaneers, while San Francisco 49'ers (1-5) take on Minnesota Vikings in an effort to get back in the win column.