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San Francisco 49ers earned a 233.36-196.78 victory to hand Denver Broncos their fifth straight loss to open the season. Denver Broncos grabbed a 65.82-point lead on Thursday behind a combined 28.7 points from Courtland Sutton (5 Rec, 74 Rec Yds) and Melvin Gordon III (54 Rush Yds, 49 Rec Yds). But San Francisco 49ers held the lead the rest of the way, powered by Jeff Wilson Jr., who racked up 132 yards from scrimmage and ran for a touchdown for 24.2 points, and Antoine Winfield Jr., who made 8 tackles and recorded a sack (23 points). San Francisco 49ers (2-3) will look to sustain their momentum against Buffalo Bills, while Denver Broncos (0-5) try to get some positive momentum against Kansas City Chiefs.