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San Francisco 49ers extended their win streak to three games with a hard-fought win over New England Patriots, securing a 197.08-183.68 victory. San Francisco 49ers never trailed in this one after grabbing a 12.00-point lead on Thursday behind C.J. Gardner-Johnson. Justin Jefferson (10 Rush Yds, 115 Rec Yds, 1 Rec TD) and Austin Ekeler (47 Rush Yds, 1 Rush TD, 24 Rec Yds, 1 Rec TD) carried the flag for New England Patriots in the loss. San Francisco 49ers (4-5) will look to notch another W against Cleveland Browns, while New England Patriots (3-6) face Chicago Bears in an effort to get back on track.