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Buffalo Bills extended their win streak to four games with a hard-fought win over San Francisco 49ers, earning a 274.06-251.20 victory. Buffalo Bills never trailed in this one after nabbing a 24.80-point lead on Thursday behind Christian McCaffrey (25.8 points) and Ryan Neal (9). Rhamondre Stevenson (172 Rush Yds, 1 Rush TD) and John Johnson III (9 Tackles) did everything they could for San Francisco 49ers in the loss. This marks the first time this season Buffalo Bills have beaten San Francisco 49ers, after falling 244.34-235.42 in their last matchup. Buffalo Bills will look to clinch the championship next week, while San Francisco 49ers attempt to bounce back and lock up 3rd Place.