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San Francisco 49'ers rolled to a 318.26-119.80 victory to hand Tampa Bay Buccaneers their third consecutive loss. San Francisco 49'ers grabbed a 33.26-point lead on Thursday behind Ryan Tannehill (31.26 points) and Denico Autry (2) and never relinquished it. Christian McCaffrey (20.6 points) and George Pickens (19.8) did everything they could for Tampa Bay Buccaneers in the loss. This marks the first time this season San Francisco 49'ers have beaten Tampa Bay Buccaneers, after falling 282.7-282.54 in their last matchup. San Francisco 49'ers (5-6) will look to add to their success against New England Patriots, while Tampa Bay Buccaneers (4-7) face off against Cincinnati Bengals in an effort to get back on track.