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Pittsburgh Steelers underachieved compared to projections, as Indianapolis Colts secured a 245.26-200.42 victory. Indianapolis Colts earned an early 22.50-point lead on Thursday. Pittsburgh Steelers came back to take the lead during the early games on Sunday, powered by Cameron Wake (17 points) and Kirk Cousins (16.32). Not to be deterred, Indianapolis Colts made a run later that afternoon, as Austin Ekeler (40.4 points) and T.Y. Hilton (28.7) put them back ahead once and for all. Indianapolis Colts (1-0) will look to add to their success against Seattle Seahawks, while Pittsburgh Steelers (0-1) take on Detroit Lions in an effort to generate some positive momentum.