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Detroit Lions earned a 227.70-144.62 win to hand Indianapolis Colts their sixth straight loss. Detroit Lions never trailed in this one after taking a 4.00-point lead on Thursday behind Zach Cunningham. Derek Carr (27.76 points) and Phillip Lindsay (20.2) were the leading performers for Indianapolis Colts in the loss. Detroit Lions (3-5) will look to sustain their momentum against Jacksonville Jaguars, while Indianapolis Colts (2-6) face Green Bay Packers in an effort to right the ship.