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San Francisco 49ers stepped up, rolling to a 297.16-176.06 victory over Indianapolis Colts, who fell short of projections. San Francisco 49ers earned a 56.80-point lead on Thursday behind Carlos Hyde (24.3 points) and Jarvis Landry (20.5) and never relinquished it. Adrian Peterson (120 Rush Yds, 2 Rush TDs) and Marshawn Lynch (64 Rush Yds, 1 Rush TD, 22 Rec Yds) did their part for Indianapolis Colts in the loss. San Francisco 49ers (2-1) will look to build on their success against Jacksonville Jaguars, while Indianapolis Colts (2-1) will meet Philadelphia Eagles in an effort to right the ship.