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Hampered by a goose egg from Kenny Young, Jacksonville Jaguars were unable to overcome San Francisco 49ers, which secured a 260.42-246.46 victory. San Francisco 49ers never trailed in this one after earning a 18.00-point lead on Thursday behind Cory Littleton. Kareem Hunt (121 Rush Yds, 1 Rush TD, 54 Rec Yds) and Giovani Bernard (69 Rush Yds, 2 Rush TDs, 27 Rec Yds) led the way for Jacksonville Jaguars in the loss. San Francisco 49ers (3-1) will look to add to their success against New England Patriots, while Jacksonville Jaguars (2-2) will attempt to get back on track against Philadelphia Eagles.